benzyl(1-phenylethyl)selane | 144403-88-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: benzyl(1-phenylethyl)selane
• 英文别名: 1-Benzylselanylethylbenzene
• CAS: 144403-88-3
• 化学式: C₁₅H₁₆Se
• 分子量: 275.252
• InChiKey: AYWMIYSIGZKNNO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.65
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  benzyl(1-phenylethyl)selane 在 sodium phosphite 、 Thermobifida fusca recombinant phenylacetone monooxygenase 、 phosphite dehydrogenase 、 NADP+ 作用下， 以 二甲基亚砜 为溶剂， 反应 5.0h， 以14%的产率得到
  参考文献：
  名称：

  Chemoenzymatic approaches to obtain chiral-centered selenium compounds

  摘要：

  The synthesis of chiral-centered selenium compounds is presented. Enantioselective oxidations of these organoselenium compounds were performed using a wide range of biocatalysts, including Baeyer-Villiger monooxygenases, oxidoreductases-containing Aspergillus terreus and lipase (Cal-B) in the presence of oxidants. Finally, efficient synthesis of enantiopure organoselenium compounds using a kinetic resolution approach mediated by Cal-B was achieved. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.09.087
• 作为产物：
  描述：

  苏合香醇 在 4-二甲氨基吡啶 、 selenium 、 sodium tetrahydroborate 作用下， 以 乙醇 、 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 22.33h， 生成 benzyl(1-phenylethyl)selane
  参考文献：
  名称：

  Chemoenzymatic approaches to obtain chiral-centered selenium compounds

  摘要：

  The synthesis of chiral-centered selenium compounds is presented. Enantioselective oxidations of these organoselenium compounds were performed using a wide range of biocatalysts, including Baeyer-Villiger monooxygenases, oxidoreductases-containing Aspergillus terreus and lipase (Cal-B) in the presence of oxidants. Finally, efficient synthesis of enantiopure organoselenium compounds using a kinetic resolution approach mediated by Cal-B was achieved. (C) 2012 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2012.09.087

文献信息

• A novel regioselective reaction of styrene with magnesium organoselenolates to afford unsymmetrical selenides catalyzed by CuI and l-proline
  作者：Fei Gao、Yu Tang、Zhi-hao Li、Feng Pan、Jun Yang、Yuan-ming Zhang

  DOI：10.1016/j.tetlet.2012.08.046

  日期：2012.10

  A novel regioselective reaction of styrene with the prepared magnesium organoselenolates from magnesium, alkyl or aryl bromides, and selenium has been developed in one pot. The reaction catalyzed by CuI and l-proline proceeded in THF, water, and toluene. The scope and limitations of this reaction have been examined. The reaction afforded unsymmetrical selenides containing 12 new compounds in good to

  在一锅中开发了苯乙烯与由镁，烷基或芳基溴化物和硒制得的有机硒化镁的新型区域选择性反应。由CuI和1-脯氨酸催化的反应在THF，水和甲苯中进行。已经检查了该反应的范围和局限性。该反应以高至高收率提供了包含12种新化合物的不对称硒化物。