N-naphthalen-1-yl-2-[7-[2-oxo-2-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)ethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetamide | 941704-40-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-naphthalen-1-yl-2-[7-[2-oxo-2-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)ethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetamide
• CAS: 941704-40-1
• 化学式: C₃₄H₅₄N₆O₇
• 分子量: 658.839
• InChiKey: OUNHKRSVPZZCDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  47
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  126
• 氢给体数：
  3
• 氢受体数：
  11

反应信息

• 作为反应物：
  描述：

  N-naphthalen-1-yl-2-[7-[2-oxo-2-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)ethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetamide 、 2-氯-N,N-二甲基乙酰胺 在 N,N-二异丙基乙胺 作用下， 以 二氯甲烷 为溶剂， 以80%的产率得到2-[4,10-bis[2-(dimethylamino)-2-oxoethyl]-7-[2-oxo-2-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)ethyl]-1,4,7,10-tetrazacyclododec-1-yl]-N-naphthalen-1-ylacetamide
  参考文献：
  名称：

  Luminescent Sensing of Dicarboxylates in Water by a Bismacrocyclic Dinuclear Eu(III) Conjugate

  摘要：

  The design, synthesis, and characterization of a novel dinuclear Eu(III) bismacrocyclic conjugate 1 center dot Eu-2 as a delayed luminescent lanthanide sensor for dicarboxylates is discussed. The sensor was shown to bind small dicarboxylic acids such as aspartic, malonic, succinic, or glutaric acid in pH 6.5 solutions. However, only malonic acid gave rise to selective Eu(III) luminescent enhancements, as the emission was reduced for all of the other acids.

  DOI：

  10.1021/ol070339r
• 作为产物：
  描述：

  氮杂-18-冠醚-6 在 三乙胺 、 calcium carbonate 、 potassium iodide 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 72.0h， 生成 N-naphthalen-1-yl-2-[7-[2-oxo-2-(1,4,7,10,13-pentaoxa-16-azacyclooctadec-16-yl)ethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetamide
  参考文献：
  名称：

  Luminescent Sensing of Dicarboxylates in Water by a Bismacrocyclic Dinuclear Eu(III) Conjugate

  摘要：

  The design, synthesis, and characterization of a novel dinuclear Eu(III) bismacrocyclic conjugate 1 center dot Eu-2 as a delayed luminescent lanthanide sensor for dicarboxylates is discussed. The sensor was shown to bind small dicarboxylic acids such as aspartic, malonic, succinic, or glutaric acid in pH 6.5 solutions. However, only malonic acid gave rise to selective Eu(III) luminescent enhancements, as the emission was reduced for all of the other acids.

  DOI：

  10.1021/ol070339r

文献信息

• Luminescent Sensing of Dicarboxylates in Water by a Bismacrocyclic Dinuclear Eu(III) Conjugate
  作者：Sally E. Plush、Thorfinnur Gunnlaugsson

  DOI：10.1021/ol070339r

  日期：2007.5.1

  The design, synthesis, and characterization of a novel dinuclear Eu(III) bismacrocyclic conjugate 1 center dot Eu-2 as a delayed luminescent lanthanide sensor for dicarboxylates is discussed. The sensor was shown to bind small dicarboxylic acids such as aspartic, malonic, succinic, or glutaric acid in pH 6.5 solutions. However, only malonic acid gave rise to selective Eu(III) luminescent enhancements, as the emission was reduced for all of the other acids.