| 1432063-17-6

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 核苷和核苷酸类似物
• CAS: 1432063-17-6
• 化学式: C₅₆H₇₅N₁₀O₃₆P₅
• 分子量: 1619.13
• InChiKey: HGBPDBBJNKCILB-ZMEYSIHWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.65
• 重原子数：
  107.0
• 可旋转键数：
  33.0
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  619.48
• 氢给体数：
  11.0
• 氢受体数：
  36.0

反应信息

• 作为反应物：
  描述：

  N-(2-(1H-indol-3-yl)ethyl)-N-(2-((2-amino-2-oxoethyl)(2-phenoxyethyl)amino)-2-oxoethyl)-2-((2-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)ethyl)amino)acetamide 、 以 水 为溶剂， 生成
  参考文献：
  名称：

  Protected Maleimide Building Blocks for the Decoration of Peptides, Peptoids, and Peptide Nucleic Acids

  摘要：

  Monomers allowing for the introduction of [2,5-dimethylfuran]-protected maleimides into polyamides such as peptides, peptide nucleic acids, and peptoids were prepared, as well as the corresponding oligomers. Suitable maleimide deprotection conditions were established in each case. The stability of the adducts generated by Michael-type maleimide-thiol reaction and Diels-Alder cycloaddition to maleimide deprotection conditions was exploited to prepare a variety of conjugates from peptide and PNA scaffolds incorporating one free and one protected maleimide. The target molecules were synthesized by using two subsequent maleimide-involving click reactions separated by a maleimide deprotection step. Carrying out maleimide deprotection and conjugation simultaneously gave better results than performing the two reactions subsequently.

  DOI：

  10.1021/bc4000614

文献信息

• Orthogonal Protection of Peptides and Peptoids for Cyclization by the Thiol–Ene Reaction and Conjugation
  作者：Xavier Elduque、Enrique Pedroso、Anna Grandas

  DOI：10.1021/jo500427c

  日期：2014.4.4

  Cyclic peptides and peptoids were prepared using the thiol-ene Michael-type reaction. The linear precursors were provided with additional functional groups allowing for subsequent conjugation: an orthogonally protected thiol, a protected maleimide, or an alkyne. The functional group for conjugation was placed either within the cycle or in an external position. The click reactions employed for conjugation with suitably derivatized nucleoside or oligonucleotides were either cycloadditions (Diels-Alder, Cu(I)-catalyzed azide alkyne) or the same Michael-type reaction as for cyclization.