15-nor-8,13-epoxy-1α,6β,7β,9α-tetrahydroxy-labdan-11-one 7-acetate | 93108-95-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 15-nor-8,13-epoxy-1α,6β,7β,9α-tetrahydroxy-labdan-11-one 7-acetate
• 英文别名: [(4aR,5S,6S,6aS,10S,10aR,10bS)-6,10,10b-trihydroxy-3,3,4a,7,7,10a-hexamethyl-1-oxo-5,6,6a,8,9,10-hexahydro-2H-benzo[f]chromen-5-yl] acetate
• CAS: 93108-95-3
• 化学式: C₂₁H₃₄O₇
• 分子量: 398.497
• InChiKey: RPDCHQYPZLWAFF-FFFLUGRYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  113
• 氢给体数：
  3
• 氢受体数：
  7

反应信息

• 作为产物：
  描述：

  15-nor-8,13-epoxy-1α,6β,7β,9α-tetrahydroxy-labdan-11-one 在 乙酸酐 作用下， 以 吡啶 、 二氯甲烷 为溶剂， 生成 15-nor-8,13-epoxy-1α,6β,7β,9α-tetrahydroxy-labdan-11-one 7-acetate
  参考文献：
  名称：

  Method for treating allergic reactions with forskolin

  摘要：

  Forskolin及其披露的衍生物可用作抗过敏剂。其中某些衍生物是新颖的。

  公开号：

  US04517200A1

文献信息

• FORSKOLIN CARBONATES AND USES THEREOF
  申请人：Roberts William J.

  公开号：US20110077292A1

  公开（公告）日：2011-03-31

  The present invention provides methods for reducing body weight. In particular, the present invention provides methods for reducing body weight by administering a composition comprising a forskolin 1α,9α-carbonate compound of the formula: where R 1 is hydrogen or a carbonyl group.

  本发明提供了减轻体重的方法。具体而言，本发明提供了通过给予包含公式中的一种forskolin 1α，9α-碳酸酯化合物的组合物来减轻体重的方法：其中R1是氢或羰基基团。
• KREUTNER, WILLIAM;GREEN, MICHAEL J.;SHUE, HO-JANE;SAKSENA, ANIL K.
  作者：KREUTNER, WILLIAM、GREEN, MICHAEL J.、SHUE, HO-JANE、SAKSENA, ANIL K.

  DOI：——

  日期：——
• METHODS AND COMPOSITIONS FOR TREATING URINARY TRACT INFECTIONS USING AGENTS THAT MIMIC OR ELEVATE CYCLIC AMP
  申请人：DUKE UNIVERSITY

  公开号：US20140128399A1

  公开（公告）日：2014-05-08

  Methods and compositions are provided for treating a urinary tract infection (UTI). The methods involve administering to a subject in need thereof a cAMP elevator or agent that mimics cAMP, particularly a labdane diterpene such as forskolin or a derivative or analog thereof in a therapeutically effective amount to treat a UTI. The methods may further include administration of at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs. Compositions of the invention include pharmaceutical compositions and kits for treating a UTI in a subject in need thereof that include therapeutically effective amounts of at least two cAMP elevators, particularly where one of the cAMP elevators is a labdane diterpene such as forskolin or a derivative or analog thereof. In particular, the compositions and kits may also include at least one cAMP elevator in combination with one or more additional active compounds from other classes of therapeutic agents, such as antimicrobial agents or cholesterol lowering drugs.
• US4517200A
  申请人：——

  公开号：US4517200A

  公开（公告）日：1985-05-14
• US4782082A
  申请人：——

  公开号：US4782082A

  公开（公告）日：1988-11-01