Boc-Pro-Gly-NH2 | 71779-28-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Pro-Gly-NH2
• 英文别名: tert-butyl (2S)-2-[(2-amino-2-oxoethyl)carbamoyl]pyrrolidine-1-carboxylate
• CAS: 71779-28-7
• 化学式: C₁₂H₂₁N₃O₄
• 分子量: 271.316
• InChiKey: FTJNQPDFCOJVTN-QMMMGPOBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  102
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Boc-Pro-Gly-NH2 在 盐酸 、 溶剂黄146 作用下， 反应 1.0h， 以99%的产率得到2-[(L-Prolyl)amino]acetamide hydrochloride
  参考文献：
  名称：

  Synthesis of novel Gn-RH analogues using Ugi-4MCR

  摘要：

  An efficient method for the synthesis of some Gn-RH analogues based on Ugi reaction has been developed. Four-component reaction of N- and C-terminus peptides, aromatic aldehydes and isocyanides affords novel Gn-RH analogues derived from triptorelin and gonadorelin. All of the products were purified using preparative HPLC and the structures were assigned according to MALDI-mass spectrometry data. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.111
• 作为产物：
  描述：

  甘氨酰胺盐酸盐 、 N-(tert-butoxycarbonyl)-D-proline 在 1-羟基苯并三唑 、 O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate 、 N,N-二异丙基乙胺 作用下， 以 乙酸乙酯 为溶剂， 以67%的产率得到Boc-Pro-Gly-NH2
  参考文献：
  名称：

  Synthesis of novel Gn-RH analogues using Ugi-4MCR

  摘要：

  An efficient method for the synthesis of some Gn-RH analogues based on Ugi reaction has been developed. Four-component reaction of N- and C-terminus peptides, aromatic aldehydes and isocyanides affords novel Gn-RH analogues derived from triptorelin and gonadorelin. All of the products were purified using preparative HPLC and the structures were assigned according to MALDI-mass spectrometry data. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2008.11.111

文献信息

• Use of D-glucopyranuronic acids and their derivatives for incorporation
  申请人：Asta Medica Aktiengesellschaft

  公开号：US05556836A1

  公开（公告）日：1996-09-17

  Use of 7-amino-L-glycero-L-gulo-2,6-anhydro-7-desoxy-heptonic acid and 2-benzoxycarbonylamino-0.sup.1 -methyl-2-desoxy-.beta.-glucopyranuronic acid, their derivatives and the enantiomorphous compounds for incorporation and for manufacture in pharmacologically active peptide hormones.

  使用7-氨基-L-甘露-L-古洛-2,6-脱水-7-去氧-庚酸和2-苯甲氧羰基氨基-0.sup.1-甲基-2-去氧-β-葡萄糖酸，它们的衍生物和对映异构体用于制造药理活性肽类激素。
• Synthesis of novel Gn-RH analogues using Ugi-4MCR
  作者：Armin Arabanian、Mahdieh Mohammadnejad、Saeed Balalaie、Jürgen H. Gross

  DOI：10.1016/j.bmcl.2008.11.111

  日期：2009.2

  An efficient method for the synthesis of some Gn-RH analogues based on Ugi reaction has been developed. Four-component reaction of N- and C-terminus peptides, aromatic aldehydes and isocyanides affords novel Gn-RH analogues derived from triptorelin and gonadorelin. All of the products were purified using preparative HPLC and the structures were assigned according to MALDI-mass spectrometry data. Crown Copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.