(Z)-(2S,8R,9S,12R)-5-(2,2-dimethylhydrazino)-12-<<(4-methoxyphenyl)methoxy>methyl>-8-methyl-9-<(triethylsilyl)oxy>-2-<(4R,6S)-2,2,4-trimethyl-1,3-dioxan-6-yl>-5-tetradecen-7-one | 131685-63-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (Z)-(2S,8R,9S,12R)-5-(2,2-dimethylhydrazino)-12-<<(4-methoxyphenyl)methoxy>methyl>-8-methyl-9-<(triethylsilyl)oxy>-2-<(4R,6S)-2,2,4-trimethyl-1,3-dioxan-6-yl>-5-tetradecen-7-one
• 英文别名: (Z,2S,8R,9S,12R)-5-(2,2-dimethylhydrazinyl)-12-[(4-methoxyphenyl)methoxymethyl]-8-methyl-9-triethylsilyloxy-2-[(4S,6R)-2,2,6-trimethyl-1,3-dioxan-4-yl]tetradec-5-en-7-one
• CAS: 131685-63-7
• 化学式: C₃₉H₇₀N₂O₆Si
• 分子量: 691.08
• InChiKey: UUTUHEPUSOHWNE-ORVIPYFDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.91
• 重原子数：
  48.0
• 可旋转键数：
  23.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  78.49
• 氢给体数：
  1.0
• 氢受体数：
  8.0

反应信息

• 作为反应物：
  描述：

  (Z)-(2S,8R,9S,12R)-5-(2,2-dimethylhydrazino)-12-<<(4-methoxyphenyl)methoxy>methyl>-8-methyl-9-<(triethylsilyl)oxy>-2-<(4R,6S)-2,2,4-trimethyl-1,3-dioxan-6-yl>-5-tetradecen-7-one 在 氢氟酸 、 水 作用下， 以 乙腈 为溶剂， 反应 18.0h， 以80%的产率得到(2S,3R,6R,8S,9S)-3,9-dimethyl-8-<(R)-2-hydroxy-1-propyl>-2-<(R)-3-<<(4-methoxyphenyl)methoxy>methyl>-1-pentyl>-1,7-dioxaspiro<5.5>undecan-4-one
  参考文献：
  名称：

  Assignment of stereochemistry in the oligomycin/rutamycin/cytovaricin family of antibiotics. Asymmetric synthesis of the rutamycin spiroketal synthon

  摘要：

  The absolute stereochemistry of the rutamycin antibiotics 2a,b has been established through asymmetric synthesis of the known degradation product 4. One of the key steps in the assemblage process involves acylation of the metalated hydrazone 6 with the N-methoxy-N-methyl amide 5. Both of these enantiomerically pure intermediates have been prepared in good overall yield and high diastereoselectivity (de > 94%). All absolute stereochemical relationships were established through alkylation and aldol bond constructions using N-acyloxazolidinone chiral auxiliaries. Subjection of 17 to acid hydrolysis/deprotection resulted in loss of protecting groups and subsequent spiroketalization to 19 (80%). Silylation of the secondary alcohol in 19 was followed by a samarium-catalyzed Meerwein-Ponndorf-Verley reduction to provide the equatorial alcohol 20 in excellent yield and stereoselectivity (de = 97%). Control experiments indicate that this surprisingly stereoselective reaction operates under kinetic control and that the observed stereochemical outcome may be the result of coordination of the reactive reducing agent to the axial spiroketal oxygen. Conversion of 20 to triol 4 afforded material that is identical with the rutamycin degradation product in all respects. These results establish that the absolute stereochemistry of the rutamycins is as shown (2a,b).

  DOI：

  10.1021/jo00313a011
• 作为产物：
  描述：

  (R)-2-ethyl-4-penten-1-ol 在 咪唑 、 sodium hydroxide 、 9-borabicyclo[3.3.1]nonane dimer 、 草酰氯 、 三甲基铝 、 sodium hydride 、 二甲基亚砜 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 27.5h， 生成 (Z)-(2S,8R,9S,12R)-5-(2,2-dimethylhydrazino)-12-<<(4-methoxyphenyl)methoxy>methyl>-8-methyl-9-<(triethylsilyl)oxy>-2-<(4R,6S)-2,2,4-trimethyl-1,3-dioxan-6-yl>-5-tetradecen-7-one
  参考文献：
  名称：

  Assignment of stereochemistry in the oligomycin/rutamycin/cytovaricin family of antibiotics. Asymmetric synthesis of the rutamycin spiroketal synthon

  摘要：

  The absolute stereochemistry of the rutamycin antibiotics 2a,b has been established through asymmetric synthesis of the known degradation product 4. One of the key steps in the assemblage process involves acylation of the metalated hydrazone 6 with the N-methoxy-N-methyl amide 5. Both of these enantiomerically pure intermediates have been prepared in good overall yield and high diastereoselectivity (de > 94%). All absolute stereochemical relationships were established through alkylation and aldol bond constructions using N-acyloxazolidinone chiral auxiliaries. Subjection of 17 to acid hydrolysis/deprotection resulted in loss of protecting groups and subsequent spiroketalization to 19 (80%). Silylation of the secondary alcohol in 19 was followed by a samarium-catalyzed Meerwein-Ponndorf-Verley reduction to provide the equatorial alcohol 20 in excellent yield and stereoselectivity (de = 97%). Control experiments indicate that this surprisingly stereoselective reaction operates under kinetic control and that the observed stereochemical outcome may be the result of coordination of the reactive reducing agent to the axial spiroketal oxygen. Conversion of 20 to triol 4 afforded material that is identical with the rutamycin degradation product in all respects. These results establish that the absolute stereochemistry of the rutamycins is as shown (2a,b).

  DOI：

  10.1021/jo00313a011

文献信息

• EVANS, DAVID A.;RIEGER, DALE L.;JONES, TODD K.;KALDOR, STEPHEN W., J. ORG. CHEM., 55,(1990) N6, C. 6260-6268
  作者：EVANS, DAVID A.、RIEGER, DALE L.、JONES, TODD K.、KALDOR, STEPHEN W.

  DOI：——

  日期：——