1-Cyclopropoxy-3-methyl-benzene | 18928-87-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-Cyclopropoxy-3-methyl-benzene
• 英文别名: 1-Cyclopropoxy-3-methylbenzene；1-cyclopropyloxy-3-methylbenzene
• CAS: 18928-87-5
• 化学式: C₁₀H₁₂O
• 分子量: 148.205
• InChiKey: VWVPOUMVSRVLAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.2
• 重原子数：
  11
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  m-tolyl-vinyl ether 在 氨 、 sodium methylate 、 sodium 作用下， 以 乙醚 为溶剂， 生成 1-Cyclopropoxy-3-methyl-benzene
  参考文献：
  名称：

  Synthesis and some reactions of gem-dihalocyclopropyl ethers

  摘要：

  DOI：

  10.1007/bf00914657

文献信息

• NOVEL IMMUNOMODULATOR AND ANTI-INFLAMMATORY COMPOUNDS
  申请人：MUTHUPPALANIAPPAN Meyyappan

  公开号：US20110275603A1

  公开（公告）日：2011-11-10

  The present invention provides dihydroorotate dehydrogenase inhibitors, methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of diseases or disorders wherein the inhibition of Dihydroorotate dehydrogenase is known to show beneficial effect.

  本发明提供了脱氢鸟苷酸脱氢酶抑制剂，其制备方法，含有它们的药物组合物以及治疗、预防和/或改善疾病或障碍的方法，其中已知抑制脱氢鸟苷酸脱氢酶具有益处效果。
• [EN] NOVEL IMMUNOMODULATOR AND ANTI INFLAMMATORY COMPOUNDS<br/>[FR] NOUVEAUX COMPOSÉS IMMUNOMODULATEURS ET ANTI-INFLAMMATOIRES
  申请人：INCOZEN THERAPEUTICS PVT LTD

  公开号：WO2011138665A1

  公开（公告）日：2011-11-10

  The present invention provides dihydroorotate dehydrogenase inhibitors of formula (I), methods of preparing them, pharmaceutical compositions containing them and methods of treatment, prevention and/or amelioration of diseases or disorders wherein the inhibition of Dihydroorotate dehydrogenase is known to show beneficial effect.

  本发明提供了式(I)的脱氢二氢乳酸脱氢酶抑制剂，其制备方法，含有它们的药物组合物以及治疗、预防和/或改善已知抑制二氢乳酸脱氢酶显示有益效果的疾病或疾病的方法。
• NOVEL ISOXAZOLE DRIVATIVE
  申请人：Ishikawa Makoto

  公开号：US20110065739A1

  公开（公告）日：2011-03-17

  Disclosed is a compound represented by formula (I) or a pharmaceutically acceptable salt thereof, which has an agonistic activity on GPR120 and is therefore useful for the treatment of diabetes, obesity or hyperlipemia. [In formula (I), the A represents a phenyl group which may be substituted by a lower alkoxy group or the like; the 13 represents a bivalent group produced by removing two hydrogen atoms from a benzene ring which may be substituted by a halogen atom or the like; X represents a lower alkylene group having 2 to 4 carbon atoms in its main chain or the like, wherein a carbon atom constituting the main chain may be substituted by an oxygen atom or the like; and Y represents a hydrogen atom or the like.]

  揭示了一种由式(I)表示的化合物或其药学上可接受的盐，该化合物对GPR120具有激动活性，因此对于治疗糖尿病、肥胖或高脂血症是有用的。【在式(I)中，A代表可能被低烷氧基或类似物取代的苯基；13代表通过从苯环中去除两个氢原子而产生的二价基团，该苯环可能被卤素原子或类似物取代；X代表具有2至4个碳原子的低烷基基团或类似物，其中构成主链的碳原子可能被氧原子或类似物取代；Y代表氢原子或类似物。】
• BENZOPYRAZOLE COMPOUND USED AS RHO KINASE INHIBITOR
  申请人：Medshine Discovery Inc.

  公开号：EP3782987A1

  公开（公告）日：2021-02-24

  The invention relates to a benzopyrazole compound used as RHO kinase inhibitor, a pharmaceutical composition and uses thereof for preparing an RHO kinase inhibiting drug, and more specifically to said compound of formula (I-1), a pharmaceutically acceptable salt and isomer thereof.

  本发明涉及一种用作 RHO 激酶抑制剂的苯并吡唑化合物、制备 RHO 激酶抑制药物的药物组合物及其用途，更具体地说，涉及所述式（I-1）化合物、其药学上可接受的盐和异构体。
• Benzopyrazole compound used as RHO kinase inhibitor
  申请人：MEDSHINE DISCOVERY INC.

  公开号：US11345678B2

  公开（公告）日：2022-05-31

  The invention relates to a benzopyrazole compound used as RHO kinase inhibitor, a pharmaceutical composition and uses thereof for preparing an RHO kinase inhibiting drug, and more specifically to said compound of formula (I-1), a pharmaceutically acceptable salt and isomer thereof.

  本发明涉及一种用作 RHO 激酶抑制剂的苯并吡唑化合物、制备 RHO 激酶抑制药物的药物组合物及其用途，更具体地说，涉及所述式（I-1）化合物、其药学上可接受的盐和异构体。