1-(2-氟乙氧基)-4-碘苯 | 132837-05-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1-(2-氟乙氧基)-4-碘苯
• 英文名称: 1-(2-fluoroethoxy)-4-iodobenzene
• 英文别名: 2-Fluoroethyl 4-iodophenyl ether
• CAS: 132837-05-9
• 化学式: C₈H₈FIO
• 分子量: 266.054
• InChiKey: GWESIUFEVINSMQ-UHFFFAOYSA-N

物化性质

• 沸点：
  271.5±25.0 °C(Predicted)
• 密度：
  1.689±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  2

安全信息

• 海关编码：
  2909309090

反应信息

• 作为反应物：
  描述：

  1-(2-氟乙氧基)-4-碘苯 在 copper diacetate 、 caesium carbonate 、 三乙胺 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 43.0h， 生成 (R)-1,1,1-trifluoro-3-((4-methoxybenzyl)oxy)propan-2-yl (1R,5S,6R)-6-(1-(4-(2-fluoroethoxy)phenyl)-1H-pyrazol-3-yl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
  参考文献：
  名称：

  Design, Synthesis, and Evaluation of ¹⁸F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes

  摘要：

  Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases. Herein we design, synthesize, and evaluate several irreversible fluorine-containing MAGL inhibitors for positron emission tomography (PET) ligand development. Compound 6 (identified from a therapeutic agent) was advanced for F-18-labeling via a novel spirocyclic iodonium ylide (SCIDY) strategy, which demonstrated high brain permeability and excellent specific binding. This work supports further development of novel F-18-labeled MAGL PET probes.

  DOI：

  10.1021/acs.jmedchem.9b00936
• 作为产物：
  描述：

  1-氟-2-碘乙烷 、 4-碘苯酚 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 2.0h， 以99%的产率得到1-(2-氟乙氧基)-4-碘苯
  参考文献：
  名称：

  Design, Synthesis, and Evaluation of ¹⁸F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes

  摘要：

  Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases. Herein we design, synthesize, and evaluate several irreversible fluorine-containing MAGL inhibitors for positron emission tomography (PET) ligand development. Compound 6 (identified from a therapeutic agent) was advanced for F-18-labeling via a novel spirocyclic iodonium ylide (SCIDY) strategy, which demonstrated high brain permeability and excellent specific binding. This work supports further development of novel F-18-labeled MAGL PET probes.

  DOI：

  10.1021/acs.jmedchem.9b00936

文献信息

• Acetylene Derivatives And Their Use For Binding And Imaging Amyloid Plaques
  申请人：Kung Hank F.

  公开号：US20080166299A1

  公开（公告）日：2008-07-10

  The invention relates to radiolabeled compounds and their use in methods of imaging amyloid deposits, as well as to methods of their manufacture. The invention also relates to compounds for inhibiting the aggregation of amyloid proteins that form amyloid deposits, methods for delivering therapeutic agents to amyloid deposits, as well as methods of making compounds that inhibit the aggregation of amyloid proteins.

  这项发明涉及放射标记化合物及其在成像淀粉样沉积方法中的应用，以及它们的制造方法。该发明还涉及用于抑制形成淀粉样沉积的淀粉蛋白聚集的化合物，将治疗剂传递至淀粉样沉积的方法，以及制造抑制淀粉蛋白聚集的化合物的方法。
• US4960884A
  申请人：——

  公开号：US4960884A

  公开（公告）日：1990-10-02
• US7678819B2
  申请人：——

  公开号：US7678819B2

  公开（公告）日：2010-03-16
• [EN] ANTIFUNGAL COMPOUND PROCESS<br/>[FR] PROCÉDÉ DE PRÉPARATION D'UN COMPOSÉ ANTIFONGIQUE
  申请人：VIAMET PHARMACEUTICALS INC

  公开号：WO2017049080A1

  公开（公告）日：2017-03-23

  The present invention relates to a process for preparing a compound of 5 or 5*, or a mixture thereof, that is useful as an antifungal agent. In particular, the invention seeks to provide new methodology for preparing compounds 7, 7* and 11, 11* and substituted derivatives thereof.
• Design, Synthesis, and Evaluation of ¹⁸F-Labeled Monoacylglycerol Lipase Inhibitors as Novel Positron Emission Tomography Probes
  作者：Zhen Chen、Wakana Mori、Hualong Fu、Michael A. Schafroth、Akiko Hatori、Tuo Shao、Genwei Zhang、Richard S. Van、Yiding Zhang、Kuan Hu、Masayuki Fujinaga、Lu Wang、Vasily Belov、Daisuke Ogasawara、Pilar Giffenig、Xiaoyun Deng、Jian Rong、Qingzhen Yu、Xiaofei Zhang、Mikhail I. Papisov、Yihan Shao、Thomas L. Collier、Jun-An Ma、Benjamin F. Cravatt、Lee Josephson、Ming-Rong Zhang、Steven H. Liang

  DOI：10.1021/acs.jmedchem.9b00936

  日期：2019.10.10

  Dysfunction of monoacylglycerol lipase (MAGL) is associated with several psychopathological disorders, including drug addiction and neurodegenerative diseases. Herein we design, synthesize, and evaluate several irreversible fluorine-containing MAGL inhibitors for positron emission tomography (PET) ligand development. Compound 6 (identified from a therapeutic agent) was advanced for F-18-labeling via a novel spirocyclic iodonium ylide (SCIDY) strategy, which demonstrated high brain permeability and excellent specific binding. This work supports further development of novel F-18-labeled MAGL PET probes.