7-[2-(5-methyl-2-phenyl-4-oxazole)ethoxyl]-2-oxo-2H-1-benzopyran-3-carboxylic acid methyl ester | 616200-89-6

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 香豆素及其衍生物
• 英文名称: 7-[2-(5-methyl-2-phenyl-4-oxazole)ethoxyl]-2-oxo-2H-1-benzopyran-3-carboxylic acid methyl ester
• 英文别名: Methyl 7-[2-(5-methyl-2-phenyl-1,3-oxazol-4-yl)ethoxy]-2-oxochromene-3-carboxylate
• CAS: 616200-89-6
• 化学式: C₂₃H₁₉NO₆
• 分子量: 405.407
• InChiKey: PIVRJBXWRRRQRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  30
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.17
• 拓扑面积：
  87.9
• 氢给体数：
  0
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  7-[2-(5-methyl-2-phenyl-4-oxazole)ethoxyl]-2-oxo-2H-1-benzopyran-3-carboxylic acid methyl ester 在 sodium hydroxide 作用下， 生成 7-[2-(5-methyl-2-phenyl-4-oxazole)ethoxyl]-2-oxo-2H-1-benzopyran-3-carboxylic acid
  参考文献：
  名称：

  Synthesis and insulin-sensitizing activity of a novel kind of benzopyran derivative

  摘要：

  A series of benzopyran derivatives was synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 6 and 11 exhibited more potent insulin-sensitizing activity than rosiglitazone. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00734-0
• 作为产物：
  描述：

  7-羟基-2-氧代-2H-苯并吡喃-3-甲酸甲酯 、 2-(5-甲基-2-苯基-1,3-恶唑-4-基)-1-乙醇 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 生成 7-[2-(5-methyl-2-phenyl-4-oxazole)ethoxyl]-2-oxo-2H-1-benzopyran-3-carboxylic acid methyl ester
  参考文献：
  名称：

  Synthesis and insulin-sensitizing activity of a novel kind of benzopyran derivative

  摘要：

  A series of benzopyran derivatives was synthesized and their insulin-sensitizing activities were evaluated in 3T3-L1 cells. Compounds 6 and 11 exhibited more potent insulin-sensitizing activity than rosiglitazone. (C) 2003 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(03)00734-0

文献信息

• Benzopyran compounds, process for preparing the same and their use
  申请人：Yang Yushe

  公开号：US20060178405A1

  公开（公告）日：2006-08-10

  The invention relates to the benzopyran compounds of formula (I), or the salts thereof, in which, the bond between 3 and 4 positions is a single or double bond; R 1 represents a hydrogen atom or a C 1-6 alkyl that can be substituted; R 2 represents a hydrogen atom, a C 1-6 alkyl that can be substituted or an aromatic carbocyclic or aromatic heterocyclic group that can be substituted. The invention also relates to a process for preparing such compounds or their salts as well as the use of such compounds or their salts in the preparation of the medicine against type II diabetes mellitus.

  本发明涉及式（I）的苯并吡喃化合物或其盐，其中3和4位置之间的键为单键或双键；R1表示氢原子或可被取代的C1-6烷基；R2表示氢原子，可被取代的C1-6烷基或可被取代的芳香环烷基或芳香杂环基。本发明还涉及制备这种化合物或其盐的方法，以及使用这种化合物或其盐制备针对II型糖尿病的药物。
• BENZOPYRAN COMPOUNDS, PROCESS FOR PREPARING THE SAME AND THEIR USE
  申请人：SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

  公开号：EP1598345A1

  公开（公告）日：2005-11-23

  The invention relates to the benzopyran compounds of formula (I), or the salts thereof, in which, the bond between 3 and 4 positions is a single or double bond; R1 represents a hydrogen atom or a C1-6 alkyl that can be substituted; R2 represents a hydrogen atom, a C1-6 alkyl that can be substituted or an aromatic carbocyclic or aromatic heterocyclic group that can be substituted. The invention also relates to a process for preparing such compounds or their salts as well as the use of such compounds or their salts in the preparation of the medicine against type II diabetes mellitus.

  本发明涉及式（I）的苯并吡喃化合物或其盐，其中，3-4位之间的键为单键或双键；R1代表氢原子或可被取代的C1-6烷基；R2代表氢原子、可被取代的C1-6烷基或可被取代的芳香碳环或芳香杂环基团。本发明还涉及制备此类化合物或其盐的工艺，以及此类化合物或其盐在制备 II 型糖尿病药物中的用途。
• EP1598345
  申请人：——

  公开号：——

  公开（公告）日：——
• US7456205B2
  申请人：——

  公开号：US7456205B2

  公开（公告）日：2008-11-25
• [EN] PPAR-ALPHA AGONISTS FOR TREATING MITOCHONDRIAL DISEASES<br/>[FR] AGONISTES DU RÉCEPTEUR PPAR-ALPHA POUR LE TRAITEMENT DE MALADIES MITOCHONDRIALES
  申请人：MITOBRIDGE INC

  公开号：WO2017044551A1

  公开（公告）日：2017-03-16

  Provided herein are methods for increasing PPARalpha activity and methods for treating PPARalpha related diseases (e.g., mitochondrial diseases).