2-[3-(Dimethylamino)-propoxy]-1,1-diphenylethanol | 63624-17-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-[3-(Dimethylamino)-propoxy]-1,1-diphenylethanol
• 英文别名: 2-[3-(Dimethylamino)propoxy]-1,1-diphenylethanol
• CAS: 63624-17-9
• 化学式: C₁₉H₂₅NO₂
• 分子量: 299.413
• InChiKey: NLTUGPYZDXPNBX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  22
• 可旋转键数：
  8
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  32.7
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,1-二苯基环氧乙烷 、 3-二甲氨基-1-丙醇 生成 2-[3-(Dimethylamino)-propoxy]-1,1-diphenylethanol
  参考文献：
  名称：

  Synthesis and preliminary pharmacological activity of aminoalkoxy isosteres of glycolate ester anticholinergics

  摘要：

  A sides of 2-(N-substituted amino)alkoxy-1,1-diphenylethanols was synthesized and evaluated for anticholinergic activity. The compounds differ structurally from the glycolate ester-type anticholinergic compounds by the bioisosteric substitution of a methylene group for the ester carbonyl moiety. The ethers which result from this change have increased lipophilicity compared to their ability to inhibit perphenazine-induced catatonia in rats. Structure-activity relationships of the compounds are discussed.

  DOI：

  10.1021/jm00220a005

文献信息

• FRIES D. S.; ANDRAKO J.; HUDGINS P., J. MED. CHEM. <JMCM-AR>, 1977, 20, NO 10, 1250-1254
  作者：FRIES D. S.、 ANDRAKO J.、 HUDGINS P.

  DOI：——

  日期：——
• Synthesis and preliminary pharmacological activity of aminoalkoxy isosteres of glycolate ester anticholinergics
  作者：David S. Fries、John Andrako、Patricia Hudgins

  DOI：10.1021/jm00220a005

  日期：1977.10

  A sides of 2-(N-substituted amino)alkoxy-1,1-diphenylethanols was synthesized and evaluated for anticholinergic activity. The compounds differ structurally from the glycolate ester-type anticholinergic compounds by the bioisosteric substitution of a methylene group for the ester carbonyl moiety. The ethers which result from this change have increased lipophilicity compared to their ability to inhibit perphenazine-induced catatonia in rats. Structure-activity relationships of the compounds are discussed.