N-[¹¹C]methyl-2-(3-methylphenyl)imidazo[1,2-a]pyrimidin-7-amine | 1638183-30-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 唑类
• 英文名称: N-[¹¹C]methyl-2-(3-methylphenyl)imidazo[1,2-a]pyrimidin-7-amine
• 英文别名: [¹¹C]RO6931643；N-((11C)Methyl)-2-(m-tolyl)imidazo(1,2-a)pyrimidin-7-amine；N-(111C)methyl-2-(3-methylphenyl)imidazo[1,2-a]pyrimidin-7-amine
• CAS: 1638183-30-8
• 化学式: C₁₄H₁₄N₄
• 分子量: 237.281
• InChiKey: HQNNPBZHBDAYAC-JVVVGQRLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(3-methylphenyl)imidazo[1,2-a]pyrimidine-7-amine 生成 N-[¹¹C]methyl-2-(3-methylphenyl)imidazo[1,2-a]pyrimidin-7-amine
  参考文献：
  名称：

  J. Med. Chem. 2017, 60, 7350-7370

  摘要：

  DOI：

文献信息

• Identification of Three Novel Radiotracers for Imaging Aggregated Tau in Alzheimer’s Disease with Positron Emission Tomography
  作者：Luca C. Gobbi、Henner Knust、Matthias Körner、Michael Honer、Christian Czech、Sara Belli、Dieter Muri、Martin R. Edelmann、Thomas Hartung、Isabella Erbsmehl、Sandra Grall-Ulsemer、Andreas Koblet、Marianne Rueher、Sandra Steiner、Hayden T. Ravert、William B. Mathews、Daniel P. Holt、Hiroto Kuwabara、Heather Valentine、Robert F. Dannals、Dean F. Wong、Edilio Borroni

  DOI：10.1021/acs.jmedchem.7b00632

  日期：2017.9.14

  disease and are prominent targets for novel therapeutics as well as for biomarkers for diagnostic in vivo imaging. In recent years much attention has been devoted to the discovery and development of new PET tracers to image tau aggregates in the living human brain. Access to a selective PET tracer to image and quantify tau aggregates represents a unique tool to support the development of any novel therapeutic

  tau和β淀粉样蛋白（Aβ）斑块的聚集体构成了阿尔茨海默氏病的组织病理学标志，是新型疗法以及用于体内诊断的生物标志物的重要靶标。近年来，人们对新型PET示踪剂的发现和开发投入了大量精力，以描绘人脑中tau聚集体的图像。获得选择性PET示踪剂以成像和定量tau聚集体的方法代表了一种独特的工具，可支持针对tau病理形式的任何新型治疗剂的开发。本文所述研究的目的是鉴定这种新颖的放射性示踪剂。这项工作的结果是，我们发现了三种新颖的PET示踪剂（2-（4- [ 11 [ C]甲氧基苯基]咪唑并[1,2- a ]吡啶7-胺7]（[ 11 C] RO6924963），N- [ 11 C]甲基-2-（3-甲基苯基）咪唑并[1,2- a ]嘧啶-7-胺8（[ 11 C] RO6931643）和[ 18 F]对tau神经原纤维缠结具有高亲和力的2-（6-氟吡啶-3--3-基）吡咯并[2,3- b：4,5- c
• 2-PHENYLIMIDAZO[1,2-A]PYRIMIDINES AS IMAGING AGENTS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20170128598A1

  公开（公告）日：2017-05-11

  The present invention relates to compounds of general formula wherein R 1 is (a) phenyl, optionally substituted by one or two substituents selected from 3 H, halogen, lower alkyl, di-methyl-amino, NHC(O)-lower alkyl, C(O)O-lower alkyl, lower alkoxy, OC( 3 H) 3 , O 11 CH 3 , OCH 2 CH 2 18 F, lower alkoxy substituted by halogen, hydroxy, lower alkyl substituted by hydroxy, S-lower alkyl, (b) heterocyclyl group, (c) benzo[d][1,3]dioxol-5-yl, (d) 2,3-dihydrobenzo[b][1,4]dioxin-6-yl, (e) indolin-2-one, or (f) heteroaryl, selected from the group consisting of thiophenyl, benzofuranyl, benzothiophenyl, pyrazinyl, and benzothiazolyl; R 2 is hydrogen, lower alkyl or lower alkyl substituted by halogen; R 3 is lower alkyl, C( 3 H) 3 , 11 CH 3 , lower alkyl substituted by halogen, —(CH 2 ) 2 —O-lower alkyl substituted by halogen or cycloalkyl; or R 2 and R 3 form together with the N-atom to which they are attach a ring containing —CH 2 CH 2 CHRCH 2 CH 2 —, —CH 2 CH 2 CHRCH 2 —, —CH 2 CHRCH 2 —, —CH 2 CH 2 —NR—CH 2 CH 2 —, —CH 2 CH 2 —O—CH 2 CH 2 —, or, R is hydrogen, halogen, lower alkyl substituted by halogen or lower alkoxy; or to a pharmaceutically acceptable acid addition salt, to a racemic mixture or to its corresponding enantiomer and/or optical isomers thereof. The compounds are suitable as imaging tool, which will improve diagnosis by identifying potential patients with excess of tau aggregates in the brain, which may be likely to develop Alzheimer's disease.
• US9801961B2
  申请人：——

  公开号：US9801961B2

  公开（公告）日：2017-10-31