3,6-Bis[(3-bromo-4-methoxyphenyl)methylidene]piperazine-2,5-dione | 708980-12-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3,6-Bis[(3-bromo-4-methoxyphenyl)methylidene]piperazine-2,5-dione
• CAS: 708980-12-5
• 化学式: C₂₀H₁₆Br₂N₂O₄
• 分子量: 508.166
• InChiKey: YONDZYQYJKZOOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  76.7
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,6-Bis[(3-bromo-4-methoxyphenyl)methylidene]piperazine-2,5-dione 、 碘甲烷 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以89%的产率得到3,6-bis[(3-bromo-4-methoxyphenyl)methylidene]-1,4-dimethylpiperazine-2,5-dione
  参考文献：
  名称：

  Diastereoselective Synthesis of Diketopiperazine Bis-α,β-epoxides

  摘要：

  Functionalized diketopiperazines (dioxopiperazines) are an important class of molecules in medicinal chemistry and material science. Herein we report a diastereoselective synthesis of diketopiperazine bis-alpha,beta-epoxides via the oxidation of exocyclic olefins. Although six diastereomers may be formed by this approach, only one or two of them were observed.

  DOI：

  10.1021/jo102096d
• 作为产物：
  描述：

  3-溴-4-甲氧基苯甲醛 、 1,4-二乙酰基哌嗪-2,5-二酮 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 以68%的产率得到3,6-Bis[(3-bromo-4-methoxyphenyl)methylidene]piperazine-2,5-dione
  参考文献：
  名称：

  Diastereoselective Synthesis of Diketopiperazine Bis-α,β-epoxides

  摘要：

  Functionalized diketopiperazines (dioxopiperazines) are an important class of molecules in medicinal chemistry and material science. Herein we report a diastereoselective synthesis of diketopiperazine bis-alpha,beta-epoxides via the oxidation of exocyclic olefins. Although six diastereomers may be formed by this approach, only one or two of them were observed.

  DOI：

  10.1021/jo102096d

文献信息

• Diastereoselective Synthesis of Diketopiperazine Bis-α,β-epoxides
  作者：Shin Ando、Amy L. Grote、Kazunori Koide

  DOI：10.1021/jo102096d

  日期：2011.2.18

  Functionalized diketopiperazines (dioxopiperazines) are an important class of molecules in medicinal chemistry and material science. Herein we report a diastereoselective synthesis of diketopiperazine bis-alpha,beta-epoxides via the oxidation of exocyclic olefins. Although six diastereomers may be formed by this approach, only one or two of them were observed.