Methyl 4-[[4-[[(4-methoxycarbonylphenyl)methylideneamino]methyl]phenyl]methyliminomethyl]benzoate | 180397-80-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Methyl 4-[[4-[[(4-methoxycarbonylphenyl)methylideneamino]methyl]phenyl]methyliminomethyl]benzoate
• CAS: 180397-80-2
• 化学式: C₂₆H₂₄N₂O₄
• 分子量: 428.488
• InChiKey: GNNYEKYOVCCVPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  32
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.15
• 拓扑面积：
  77.3
• 氢给体数：
  0
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Methyl 4-[[4-[[(4-methoxycarbonylphenyl)methylideneamino]methyl]phenyl]methyliminomethyl]benzoate 在 4-二甲氨基吡啶 、 sodium tetrahydroborate 、 N-氯代丁二酰亚胺 、 lithium aluminium tetrahydride 、 sodium azide 、 三苯基膦 、 三氟乙酸 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 氯仿 、 丙酮 为溶剂， 反应 3.0h， 生成 (4-Azidomethyl-benzyl)-{4-[(4-azidomethyl-benzylamino)-methyl]-benzyl}-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Molecular Shuttles by the Protecting Group Approach

  摘要：

  Two new [2]rotaxane-based molecular shuttles, in which a mechanically bound dibenzo[24]crown-8 (DB24C8) macroring shunts back and forth between two dialkylammonium recognition sites situated on a chemical dumbbell, have been constructed by a novel synthetic strategy that relies upon the use of the tert-butoxycarbonyl (Boc) protecting group. During the syntheses of both molecular shuttles, this protecting group masks a dialkylammonium recognition center which is liberated only after the [2]rotaxane constitution is established. In both cases, the molecular shuttles' other dialkylammonium center is essential for the rotaxane-forming reactions and it ensures that DB24C8 is interpenetrated by threadlike precursors, as a result of noncovalent bonding interactions, to produce [2]pseudorotaxanes which are stoppered subsequently through 1,3-dipolar cycloadditions between azides and bulky acetylenedicarboxylates. The new molecular shuttles have been examined by means of dynamic H-1 NMR spectroscopy, which reveals that the movements of the DB24C8 macroring are very highly dependent both on solvent properties and on the nature of the spacer unit linking the two dialkylammonium centers. Thus, DB24C8 shunts facilely between the dialkylammonium centers when the shuttles are dissolved in solvents that readily donate their nonbonding electrons into noncovalent bonds, e.g., DMF, and when spacer units that do not offer much steric resistance to shuttling, e.g., hexamethylene, are used. On the other hand, shuttling is difficult in solvents that are less inclined to donate their electrons into noncovalent bonds, e.g., (CDCl2)(2), and when relatively bulky benzenoid spacer units, e.g., p-xylylene, link the two dialkylammonium centers. It has been proposed that the DB24C8 might act as a "ferry" which carries a proton between dialkylammonium and dialkylamine moieties in a singly protonated [2]rotaxane by means of ion-dipole interactions.

  DOI：

  10.1021/jo991397w
• 作为产物：
  描述：

  1,4-苯二甲胺 、 对甲酰基苯甲酸甲酯 反应 24.0h， 以85%的产率得到Methyl 4-[[4-[[(4-methoxycarbonylphenyl)methylideneamino]methyl]phenyl]methyliminomethyl]benzoate
  参考文献：
  名称：

  含移动离子梭的碱性阴离子交换膜

  摘要：

  开发了一种新型的包含可移动离子对的碱性阴离子交换膜。它是通过主客体分子相互作用将离子型线性客体穿入聚（冠醚）主体中来实现的。的热-和PH引发穿梭的离子线性客人显着增加在非活性水合氢氧化物离子络合物（OH溶剂化壳波动-（H 2 O）4）和加速OH -运输。

  DOI：

  10.1002/adma.201506199

文献信息

• Ashton, Peter R.; Glink, Peter T.; Stoddart, J. Fraser, Chemistry - A European Journal, 1996, vol. 2, # 6, p. 729 - 736
  作者：Ashton, Peter R.、Glink, Peter T.、Stoddart, J. Fraser、Tasker, Peter A.、White, Andrew J. P.、Williams, David J.

  DOI：——

  日期：——