3-((3-hydroxybenzyl)oxy)benzaldehyde | 903562-00-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 3-((3-hydroxybenzyl)oxy)benzaldehyde
• 英文别名: 3-[(3-Hydroxyphenyl)methoxy]benzaldehyde；3-[(3-hydroxyphenyl)methoxy]benzaldehyde
• CAS: 903562-00-5
• 化学式: C₁₄H₁₂O₃
• 分子量: 228.247
• InChiKey: JZFJDUBGFAJWCY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  17
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-((3-hydroxybenzyl)oxy)benzaldehyde 在 sodium tetrahydroborate 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 (3-{3-[3-(Phenyl-pyren-1-yl-amino)-benzyloxy]-benzyloxy}-phenyl)-methanol
  参考文献：
  名称：

  Dendrimer Analogues of Linear Molecules to Evaluate Energy and Charge-Transfer Properties

  摘要：

  We have designed and synthesized difunctionalized dendrimers containing two donors in the periphery and an acceptor at the core to serve as scaffolds for comparison with linear analogues to investigate the advantage of dendritic scaffolds for energy and charge transfer. Comparison of these dendrimers with the fully decorated dendrimers provides information on the advantage of chromophore density in energy/charge transfer from periphery to the core.

  DOI：

  10.1021/ol0608956
• 作为产物：
  描述：

  3-甲氧基甲氧基苄醇 在 对甲苯磺酸 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 乙醇 为溶剂， 反应 3.0h， 生成 3-((3-hydroxybenzyl)oxy)benzaldehyde
  参考文献：
  名称：

  Dendrimer Analogues of Linear Molecules to Evaluate Energy and Charge-Transfer Properties

  摘要：

  We have designed and synthesized difunctionalized dendrimers containing two donors in the periphery and an acceptor at the core to serve as scaffolds for comparison with linear analogues to investigate the advantage of dendritic scaffolds for energy and charge transfer. Comparison of these dendrimers with the fully decorated dendrimers provides information on the advantage of chromophore density in energy/charge transfer from periphery to the core.

  DOI：

  10.1021/ol0608956

文献信息

• [EN] COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY<br/>[FR] COMPOSÉS AYANT UNE ACTIVITÉ D'ANTAGONISTE DES RÉCEPTEURS MUSCARINIQUES ET D'AGONISTE DES RÉCEPTEURS ADRÉNERGIQUES BÊTA2
  申请人：CHIESI FARM SPA

  公开号：WO2017093208A1

  公开（公告）日：2017-06-08

  The present invention relates to compounds acting both as muscarinic receptor antagonists and beta2 adrenergic receptor agonists, to processes for their preparation, to compositions comprising them, to therapeutic uses and combinations with other pharmaceutical active ingredients.

  这项发明涉及既作为肌肉胆碱受体拮抗剂又作为β2肾上腺素受体激动剂的化合物，涉及它们的制备方法，包含它们的组合物，治疗用途以及与其他药用活性成分的组合。
• COMPOUNDS HAVING MUSCARINIC RECEPTOR ANTAGONIST AND BETA2 ADRENERGIC RECEPTOR AGONIST ACTIVITY
  申请人：Chiesi Farmaceutici S.p.A.

  公开号：EP3383867A1

  公开（公告）日：2018-10-10
• US9932338B2
  申请人：——

  公开号：US9932338B2

  公开（公告）日：2018-04-03
• Dendrimer Analogues of Linear Molecules to Evaluate Energy and Charge-Transfer Properties
  作者：Arpornrat Nantalaksakul、Raghunath Reddy Dasari、Tai-Sang Ahn、Rabih Al-Kaysi、Christopher J. Bardeen、S. Thayumanavan

  DOI：10.1021/ol0608956

  日期：2006.7.1

  We have designed and synthesized difunctionalized dendrimers containing two donors in the periphery and an acceptor at the core to serve as scaffolds for comparison with linear analogues to investigate the advantage of dendritic scaffolds for energy and charge transfer. Comparison of these dendrimers with the fully decorated dendrimers provides information on the advantage of chromophore density in energy/charge transfer from periphery to the core.