{4-[3-Ethyl-4,5-bis-(4-methoxy-phenyl)-furan-2-yl]-phenoxy}-triisopropyl-silane | 386748-23-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: {4-[3-Ethyl-4,5-bis-(4-methoxy-phenyl)-furan-2-yl]-phenoxy}-triisopropyl-silane
• 英文别名: [4-[3-Ethyl-4,5-bis(4-methoxyphenyl)furan-2-yl]phenoxy]-tri(propan-2-yl)silane；[4-[3-ethyl-4,5-bis(4-methoxyphenyl)furan-2-yl]phenoxy]-tri(propan-2-yl)silane
• CAS: 386748-23-8
• 化学式: C₃₅H₄₄O₄Si
• 分子量: 556.817
• InChiKey: BTFYCQGIYNHNCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.41
• 重原子数：
  40
• 可旋转键数：
  11
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  40.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  {4-[3-Ethyl-4,5-bis-(4-methoxy-phenyl)-furan-2-yl]-phenoxy}-triisopropyl-silane 在 偶氮二甲酸二异丙酯 、 四丁基氟化铵 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 生成 1-(2-{4-[3-Ethyl-4,5-bis-(4-methoxy-phenyl)-furan-2-yl]-phenoxy}-ethyl)-piperidine
  参考文献：
  名称：

  Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha

  摘要：

  3-Alkyl-2,4,5-triarylfurans with basic side-chain substituents were prepared as ligands for the estrogen receptor. Those analogues having the basic side chain on the C(4) phenol were high-affinity, ER alpha -selective antagonists. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(01)00488-7
• 作为产物：
  描述：

  脱氧茴香偶姻 在 双(三甲基硅烷基)氨基钾 、 对甲苯磺酸 作用下， 以 甲苯 为溶剂， 生成 {4-[3-Ethyl-4,5-bis-(4-methoxy-phenyl)-furan-2-yl]-phenoxy}-triisopropyl-silane
  参考文献：
  名称：

  Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha

  摘要：

  3-Alkyl-2,4,5-triarylfurans with basic side-chain substituents were prepared as ligands for the estrogen receptor. Those analogues having the basic side chain on the C(4) phenol were high-affinity, ER alpha -selective antagonists. (C) 2001 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0960-894x(01)00488-7

文献信息

• Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha
  作者：Deborah S. Mortensen、Alice L. Rodriguez、Jun Sun、Benita S. Katzenellenbogen、John A. Katzenellenbogen

  DOI：10.1016/s0960-894x(01)00488-7

  日期：2001.9

  3-Alkyl-2,4,5-triarylfurans with basic side-chain substituents were prepared as ligands for the estrogen receptor. Those analogues having the basic side chain on the C(4) phenol were high-affinity, ER alpha -selective antagonists. (C) 2001 Published by Elsevier Science Ltd.