2,5-diaminobenzimidazole dihydrochloride salt

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2,5-diaminobenzimidazole dihydrochloride salt
• 英文别名: 1H-benzo[d]imidazole-2,5-diamine dihydrochloride；3H-benzimidazole-2,5-diamine;hydrochloride
• 化学式: C₇H₈N₄*2ClH
• 分子量: 221.089
• InChiKey: QYQXKKAWDJOHKI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.15
• 重原子数：
  12
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  80.7
• 氢给体数：
  4
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨基-6-硝基苯并咪唑 在 二碳酸二叔丁酯 、 10% palladium on carbon 、 氢气 作用下， 以 四氢呋喃 、 甲醇 为溶剂， 生成 2,5-diaminobenzimidazole dihydrochloride salt
  参考文献：
  名称：

  The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii

  摘要：

  Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains. (C) 2009 Published by Elsevier Ltd.

  DOI：

  10.1016/j.bmc.2009.12.003

文献信息

• [EN] DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS<br/>[FR] DIAMINO-PYRIMIDINES ET LEURS UTILISATIONS EN TANT QU'INHIBITEURS DE L'ANGIOGENESE
  申请人：SMITHKLINE BEECHAM CORP

  公开号：WO2003074515A1

  公开（公告）日：2003-09-12

  Benzimidazole derivatives of formula (I) , which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases. (I)

  本发明描述了公式(I)的苯并咪唑衍生物，它们作为TIE-2和/或VEGFR-2抑制剂是有用的。所描述的发明还包括制造这样的苯并咪唑衍生物的方法，以及使用它们在治疗增生性疾病中的方法。
• 2-Aminobenzimidazole Derivatives Strongly Inhibit and Disperse<i>Pseudomonas aeruginosa</i>Biofilms
  作者：Reto Frei、Anthony S. Breitbach、Helen E. Blackwell

  DOI：10.1002/anie.201109258

  日期：2012.5.21

  antibiotics and constitute a significant health threat. 2‐Aminobenzimidazole derivatives (see scheme) are capable of strongly inhibiting the growth of and dispersing Pseudomonas aeruginosa biofilms. These molecules were found to modulate quorum sensing in reporter strains, and represent some of strongest P. aeruginosa biofilm inhibitors known.

  使用传统抗生素很难清除细菌生物膜，对健康构成重大威胁。2-氨基苯并咪唑衍生物（见方案）能够强烈抑制铜绿假单胞菌生物膜的生长和分散。发现这些分子可调节报告菌株中的群体感应，并代表一些已知的最强铜绿假单胞菌生物膜抑制剂。
• DIAMINO-PYRIMIDINES AND THEIR USE AS ANGIOGENESIS INHIBITORS
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP1487824A1

  公开（公告）日：2004-12-22
• US4321363A
  申请人：——

  公开号：US4321363A

  公开（公告）日：1982-03-23
• The chemical synthesis and antibiotic activity of a diverse library of 2-aminobenzimidazole small molecules against MRSA and multidrug-resistant A. baumannii
  作者：Robert W. Huigens、Samuel Reyes、Catherine S. Reed、Cynthia Bunders、Steven A. Rogers、Andrew T. Steinhauer、Christian Melander

  DOI：10.1016/j.bmc.2009.12.003

  日期：2010.1

  Multidrug-resistant bacterial infections continue to be a rising global health concern. Herein is described the development of a class of novel 2-aminobenzimidazoles with antibiotic activity. These active 2-aminobenzimidazoles retain their antibiotic activity against several strains of multidrug-resistant Staphylococcus aureus and Acinetobacter baumannii when compared to susceptible strains. (C) 2009 Published by Elsevier Ltd.