N_α-Boc-N_ε-Z-L-lysyl-1-aminopropane | 92278-14-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N_α-Boc-N_ε-Z-L-lysyl-1-aminopropane
• 英文别名: benzyl N-[(5S)-5-[(2-methylpropan-2-yl)oxycarbonylamino]-6-oxo-6-(propylamino)hexyl]carbamate
• CAS: 92278-14-3
• 化学式: C₂₂H₃₅N₃O₅
• 分子量: 421.537
• InChiKey: ZLBZUUZABFILLE-SFHVURJKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  30
• 可旋转键数：
  14
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  106
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  N_α-Boc-N_ε-Z-L-lysyl-1-aminopropane 在 palladium on activated charcoal 氢气 作用下， 以 甲醇 为溶剂， 反应 16.0h， 以288 mg的产率得到((S)-5-Amino-1-propylcarbamoyl-pentyl)-carbamic acid tert-butyl ester
  参考文献：
  名称：

  Supramolecular Structures from Lysine Peptides and Carbon Dioxide

  摘要：

  The design, synthesis, and characterization of novel linear and cross-linked supramolecular polymers that are easily available from biologically friendly lysine peptides and carbon dioxide (CO2) are reported here. Polymeric structures 5, 6, and 19 readily form from peptides 2, 3, and 15, respectively, at ambient temperatures by simply bubbling CO2 through their solutions in apolar organic solvents (CHCl3, benzene) and even in the presence of 10% MeOH. The resulting gels can be easily isolated from solution, dried, and stored refrigerated for several months. At the same time, they may thermally release CO2 and convert back to the corresponding monomers. As a consequence, their structures and physical properties are switchable. They may also trap, store, and release foreign molecules. The typical entrapment procedure was demonstrated for tripeptide 3, CO2, and the commercially available dye coumarin 2.

  DOI：

  10.1021/jo061144k
• 作为产物：
  描述：

  正丙胺 、 N-Boc-N'-Cbz-L-赖氨酸 在 O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate 、 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.08h， 生成 N_α-Boc-N_ε-Z-L-lysyl-1-aminopropane
  参考文献：
  名称：

  表面的横向自分类：双通道光系统的实用方法

  摘要：

  我们报告说，自组织表面引发共聚（co-SOSIP）过程中的自分类提供了对定向多组分体系结构的轻松访问。发现交替横向和均匀轴向自分类到正式的超分子 n/p-异质结光系统中，产生高达 40 倍的光电流。或多或少的拓扑匹配分别导致交替轴向自分选到非活性电荷转移复合物或均匀横向分选到不太活跃的宏域中。报告了在 co-SOSIP 期间对自我修复的实验支持。表面上的引发剂被证明可以作为自分类到具有自由可变成分的多通道架构的模板。

  DOI：

  10.1021/ja204020p

文献信息

• Monohaptenic N?-Benzoyl-L-lysine Derivatives as Anaphylactogens: the Importance of the Unsubstituted Carboxyl Group
  作者：Raymond Guenin、Conrad H. Schneider

  DOI：10.1002/hlca.19840670411

  日期：1984.6.20

  Nα-L-Iysine with a 2-carboxy-4, 6-dinitrophenyl (Dncp) haptenic group on the ε-amino function is a potent anaphylactogen in the guinea pig. We prepared Nε -Dncp- Nα-benzoly-L-Iysinamide and Nε-Dncp-Nα-benzoyl-L-lysyl-1-aminopropane where the carboxyl group of Iysine is blocked. Both compounds were non-elections of anaphylaxis.

  Ñ α -L-Iysine与2-羧基4,6二硝基苯基（DNCP）在ε氨基功能半抗原组是在豚鼠的有效的过敏原。我们制备Ñ ε -Dncp- Ñ α -benzoly-L-Iysinamide和Ñ ε -Dncp- Ñ α -苯甲酰基-L-赖氨酰-1-氨基丙烷，其中Iysine的羧基被阻止。两种化合物都不是过敏反应的选择。
• Supramolecular Structures from Lysine Peptides and Carbon Dioxide
  作者：Vaclav Stastny、Anjenique Anderson、Dmitry M. Rudkevich

  DOI：10.1021/jo061144k

  日期：2006.11.1

  The design, synthesis, and characterization of novel linear and cross-linked supramolecular polymers that are easily available from biologically friendly lysine peptides and carbon dioxide (CO2) are reported here. Polymeric structures 5, 6, and 19 readily form from peptides 2, 3, and 15, respectively, at ambient temperatures by simply bubbling CO2 through their solutions in apolar organic solvents (CHCl3, benzene) and even in the presence of 10% MeOH. The resulting gels can be easily isolated from solution, dried, and stored refrigerated for several months. At the same time, they may thermally release CO2 and convert back to the corresponding monomers. As a consequence, their structures and physical properties are switchable. They may also trap, store, and release foreign molecules. The typical entrapment procedure was demonstrated for tripeptide 3, CO2, and the commercially available dye coumarin 2.
• Lateral Self-Sorting on Surfaces: A Practical Approach to Double-Channel Photosystems
  作者：Marco Lista、Jetsuda Areephong、Naomi Sakai、Stefan Matile

  DOI：10.1021/ja204020p

  日期：2011.10.5

  We report that self-sorting during self-organizing surface-initiated copolymerization (co-SOSIP) provides facile access to oriented multicomponent architectures. Alternate lateral and uniform axial self-sorting into formal supramolecular n/p-heterojunction photosystems is found to generate up to 40 times more photocurrent. More or less topological matching gives rise to alternate axial self-sorting

  我们报告说，自组织表面引发共聚（co-SOSIP）过程中的自分类提供了对定向多组分体系结构的轻松访问。发现交替横向和均匀轴向自分类到正式的超分子 n/p-异质结光系统中，产生高达 40 倍的光电流。或多或少的拓扑匹配分别导致交替轴向自分选到非活性电荷转移复合物或均匀横向分选到不太活跃的宏域中。报告了在 co-SOSIP 期间对自我修复的实验支持。表面上的引发剂被证明可以作为自分类到具有自由可变成分的多通道架构的模板。