2-nitro-5-oxohexanenitrile | 1307949-24-1

• 分子结构分类: 有机化合物 - 有机1,3-偶极化合物 - 烯丙基型1,3-偶极有机化合物
• 英文名称: 2-nitro-5-oxohexanenitrile
• 英文别名: 2-Nitro-5-oxohexanenitrile
• CAS: 1307949-24-1
• 化学式: C₆H₈N₂O₃
• 分子量: 156.141
• InChiKey: YAQNFACKAFSRHQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  86.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-nitro-5-oxohexanenitrile 以 乙腈 为溶剂， 反应 3.0h， 生成 1,7-diaza-2-imino-6-methyl-3-aci-nitrobicyclo[4.3.0]nonane
  参考文献：
  名称：

  Bicyclization involving pseudo-intramolecular imination with diamines

  摘要：

  α-硝基-δ-酮腈和α-硝基-δ-酮酯经二胺处理后很容易转化为具有邻接官能团的二氮杂双环化合物。酮腈吸引二胺附近的酸性氢，导致伪分子内亚氨基化，这种亚氨基化在室温下无需任何催化剂即可高效进行。

  DOI：

  10.1039/c1cc10705d
• 作为产物：
  描述：

  丁烯酮 、 4-硝基-5(2)-异恶唑酮吡啶盐 在 四氢吡咯 作用下， 以 苯 为溶剂， 反应 2.0h， 以88%的产率得到2-nitro-5-oxohexanenitrile
  参考文献：
  名称：

  Bicyclization involving pseudo-intramolecular imination with diamines

  摘要：

  α-硝基-δ-酮腈和α-硝基-δ-酮酯经二胺处理后很容易转化为具有邻接官能团的二氮杂双环化合物。酮腈吸引二胺附近的酸性氢，导致伪分子内亚氨基化，这种亚氨基化在室温下无需任何催化剂即可高效进行。

  DOI：

  10.1039/c1cc10705d

文献信息

• Safe cyano(nitro)methylating reagent—Michael addition of cyano-aci-nitroacetate leading to δ-functionalized α-nitronitriles
  作者：Haruyasu Asahara、Kyo Muto、Nagatoshi Nishiwaki

  DOI：10.1016/j.tet.2014.07.013

  日期：2014.9

  A practical, convenient, and safe cyano(nitro)methylation method was developed, in which cyano-aci-nitroacetate served as a synthetic equivalent of anionic nitroacetonitrile. A control of the single/double Michael additions was achieved, which enabled the synthesis of unsymmetrical double Michael adducts. Moreover, the Michael adducts can be used as precursors of pyridine and naphthyridine frameworks. (C) 2014 Elsevier Ltd. All rights reserved.
• Synthesis of vicinally functionalized 1,4-dihydropyridines and diazabicycles via a pseudo-intramolecular process
  作者：Nagatoshi Nishiwaki、Shotaro Hirao、Jun Sawayama、Haruyasu Asahara、Ryuichi Sugimoto、Kazuya Kobiro、Kazuhiko Saigo

  DOI：10.1016/j.tet.2013.11.044

  日期：2014.1

  An alpha-nitro-delta-keto nitrile readily forms the corresponding ammonium salt immediately upon treatment with an amine. When the amine liberated under equilibrium, the nucleophilic amine and the electrophilic keto nitrile come close to each other to afford so-called an intimate pair. The spatial proximity realized an efficient reaction to give a 2-amino-3-nitro-1,4-dihydropyridine; the reaction proceeded like an intramolecular reaction although it is actually an intermolecular reaction, namely the pseudo-intramolecular reaction. The bifunctionality of the keto nitrile also enabled the pseudo-intramolecular imination followed by tandem cyclization leading to diazabicyclic frameworks. (C) 2013 Elsevier Ltd. All rights reserved.
• Bicyclization involving pseudo-intramolecular imination with diamines
  作者：Nagatoshi Nishiwaki、Shotaro Hirao、Jun Sawayama、Kazuhiko Saigo、Kazuya Kobiro

  DOI：10.1039/c1cc10705d

  日期：——

  α-Nitro-δ-keto nitriles and α-nitro-δ-keto ester were readily converted to diazabicyclo compounds having vicinal functionality upon treatment with diamines. The keto nitrile attracts the diamine nearby to an acidic hydrogen to cause the pseudo-intramolecular imination which proceeds efficiently without any catalyst at room temperature.

  α-硝基-δ-酮腈和α-硝基-δ-酮酯经二胺处理后很容易转化为具有邻接官能团的二氮杂双环化合物。酮腈吸引二胺附近的酸性氢，导致伪分子内亚氨基化，这种亚氨基化在室温下无需任何催化剂即可高效进行。