N-((S)-3-oxo-1,3-diphenylpropyl)benzamide | 91875-49-9

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: N-((S)-3-oxo-1,3-diphenylpropyl)benzamide
• 英文别名: (S)-N-(3-oxo-1,3-diphenylpropyl)benzamide；(S)-3-benzoylamino-1,3-diphenyl-propan-1-one；(S)-3-Benzoylamino-1,3-diphenyl-propan-1-on；N-[(1S)-3-oxo-1,3-diphenylpropyl]benzamide
• CAS: 91875-49-9
• 化学式: C₂₂H₁₉NO₂
• 分子量: 329.398
• InChiKey: QTBKOGLJPINUKJ-FQEVSTJZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  46.2
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  N-[甲氧基(苯基)甲基]苯甲酰胺 在 (R)-[3-(9-anthryl)-2-hydroxynaphth-1-yl]2 cyclic phosphate 、 potassium carbonate 、 sodium sulfate 作用下， 以 甲苯 为溶剂， 反应 20.5h， 生成 N-((S)-3-oxo-1,3-diphenylpropyl)benzamide
  参考文献：
  名称：

  手性布朗斯台德酸的高底物/催化剂有机催化作用，用于对映选择性氮杂-烯型反应。

  摘要：

  DOI：

  10.1002/anie.200503477

文献信息

• Asymmetric synthesis of 4H-1,3-oxazines: enantioselective reductive cyclization of N-acylated β-amino enones with trichlorosilane catalyzed by chiral Lewis bases
  作者：Masaharu Sugiura、Mako Kumahara、Makoto Nakajima

  DOI：10.1039/b905102c

  日期：——

  N-Acylated beta-amino enones reductively cyclize by treatment with trichlorosilane and a chiral Lewis base catalyst to afford optically active 4H-1,3-oxazines, which can be transformed to other chiral compounds without racemization.

  通过用三氯硅烷和手性路易斯碱催化剂处理，N-酰化的β-氨基烯酮还原环化，得到旋光的4H-1,3-恶嗪，可以将其转化为其他手性化合物而无需外消旋化。
• Asymmetric Amplification in Phosphoric Acid Catalyzed Reactions
  作者：Nan Li、Xiao-Hua Chen、Shi-Ming Zhou、Shi-Wei Luo、Jin Song、Lei Ren、Liu-Zhu Gong

  DOI：10.1002/anie.201001723

  日期：2010.8.23

  reactions catalyzed by phosphoric acids arose from the formation of less soluble supramolecular structures (see scheme; O red, P yellow, C gray, H white) of the racemic phosphoric acids that participate in hydrogen bonds with the crystalline water molecules. The finding shows that highly enantioselective reactions can be observed by using non‐optically pure phosphoric acids.

  一个 EE 安培：不对称扩增在由磷酸类催化反应从较少溶解的超分子结构的形成产生（参见方案; O型红，P黄色，C灰色，H白）的参与氢键与结晶外消旋磷酸水分子。该发现表明，使用非光学纯的磷酸可以观察到高度对映选择性的反应。
• Pulmonary cryptococcosis and Capillaria aerophila infection in an FIV-positive cat
  作者：VR BARRS、P. MARTIN、RG NICOLL、JA BEATTY、R. MALIK

  DOI：10.1111/j.1751-0813.2000.tb10581.x

  日期：2000.3

  A 12‐year‐old, FIV‐positive, domestic longhair cat was presented with a history of sneezing and coughing during the previous seven months. On thoracic radiographs, a prominent bronchial pattern and three focal, opacified nodules were seen. Cytology of bronchoalveolar lavage fluid demonstrated spherical, capsulate, narrow‐necked, budding yeasts within macrophages. Culture of the fluid yielded a heavy growth of Cryptococcus neoformans var neoformans. The serum latex cryptococcal antigen agglutination test titre was 158. The cat was treated with itraconazole and the cough resolved over a 5‐month period but then recurred. Repeat thoracic radiographs showed resolution of the pulmonary nodules but a persistent bronchial pattern. Adult nematodes and ova with morphology characteristic of Capillaria aerophila were seen in bronchoalveolar lavage fluid and no yeasts were cultured from the fluid. The cryptococcal titre was zero. The lungworm infection was treated successfully with abamectin and the cough resolved. Immunosuppression related to FIV infection may have predisposed this cat to sequential respiratory tract infections.
• High Substrate/Catalyst Organocatalysis by a Chiral Brønsted Acid for an Enantioselective Aza-Ene-Type Reaction
  作者：Masahiro Terada、Kyoko Machioka、Keiichi Sorimachi

  DOI：10.1002/anie.200503477

  日期：2006.3.27