methyl {(1R,2R)-2-[(tert-butoxycarbonyl)amino]-2,3-dihydro-1H-inden-1-yl}acetate | 904295-45-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl {(1R,2R)-2-[(tert-butoxycarbonyl)amino]-2,3-dihydro-1H-inden-1-yl}acetate
• 英文别名: methyl 2-[(1R,2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-2,3-dihydro-1H-inden-1-yl]acetate
• CAS: 904295-45-0
• 化学式: C₁₇H₂₃NO₄
• 分子量: 305.374
• InChiKey: JOBYUAGBMQLJBH-ZIAGYGMSSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  64.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  methyl {(1R,2R)-2-[(tert-butoxycarbonyl)amino]-2,3-dihydro-1H-inden-1-yl}acetate 在 盐酸 作用下， 以 1,4-二氧六环 、 二氯甲烷 为溶剂， 反应 1.0h， 以91%的产率得到methyl [(1R,2R)-2-amino-2,3-dihydro-1H-inden-1-yl]acetate hydrochloride
  参考文献：
  名称：

  WO2006/82400

  摘要：

  公开号：
• 作为产物：
  描述：

  (1S,2S)-1-[(tert-butoxycarbonyl)amino]-2,3-dihydro-1H-inden-2-yl methanesulfonate 在 水 、 sodium chloride 作用下， 以 二甲基亚砜 为溶剂， 反应 46.0h， 以68%的产率得到methyl {(1R,2R)-2-[(tert-butoxycarbonyl)amino]-2,3-dihydro-1H-inden-1-yl}acetate
  参考文献：
  名称：

  WO2006/82401

  摘要：

  公开号：

文献信息

• Indan-Amide Derivatives with Glycogen Phosphorylase Inhibitory Activity
  申请人：Birch Alan Martin

  公开号：US20090124682A1

  公开（公告）日：2009-05-14

  A compound of the formula (1) or a pharmaceutically-acceptable salt: (A chemical formula should be inserted here—please see paper copy enclosed herewith) (1) possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of compounds and pharmaceutical compositions containing them are described.

  化合物的化学式（1）或其药学上可接受的盐：（化学式请参见随附的纸质副本）（1）具有糖原磷酸化酶抑制活性，因此对于治疗与糖原磷酸化酶活性增加相关的疾病状态具有价值。本文描述了制备化合物和含有它们的制药组合物的过程。
• Chemical Compounds
  申请人：Birch Alan Martin

  公开号：US20100137397A1

  公开（公告）日：2010-06-03

  A compound of the formula (1) or a pharmaceutically-acceptable salt: possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity such as 2 diabetes. Processes for the manufacture of compounds and pharmaceutical compositions containing them are described.

  公式（1）的化合物或药学上可接受的盐：具有糖原磷酸化酶抑制活性，因此在治疗与糖原磷酸化酶活性增加相关的疾病状态，如2型糖尿病方面具有价值。本文描述了制备这些化合物和含有它们的制药组合物的过程。
• HETEROCYCLIC AMIDE DERIVATIVES WHICH POSSESS GLYCOGEN PHOSPHORYLASE INHIBITORY ACTIVITY
  申请人：AstraZeneca AB

  公开号：EP1658069B1

  公开（公告）日：2008-07-30
• Heterocyclic Amide Derivatives Which Possess Glycogen Phosphorylase Inhibitory Activity
  申请人：Birch Alan Martin

  公开号：US20080064691A1

  公开（公告）日：2008-03-13

  A compound of the formula (1) or a pharmaceutically-acceptable salt, or pro-drug thereof; wherein, for example, Z is CH or nitrogen, R 4 and R 5 together are either —S—C(R 6 )═C(R7)— or —C(R 7 )═C(R 6 )—S—; R 6 and R 7 are independently selected from hydrogen, halo, nitro, cyano, hydroxy, fluoromethyl, difluoromethyl, trifluoromethyl, trifluoromethoxy, carboxy and carbamoyl; A is phenylene or heteroarylene; n is 0, 1 or 2; r is 1 or 2; R 1 is halo, cyano or carboxy; Y is selected from —C(O)R 2 , —C(O)OR 2 , —C(O)NR 2 R 3 , -(1-4C)alkyl [optionally substituted] -(2-4C)alkenyl, —SO 2 NR 2 R 3 , and —S(O) c R 2 (wherein c is 0, 1 or 2); R 2 and R 3 are independently selected from hydrogen, —O(1-4C)alkyl, —S(1-4C)alkyl, —N(1-4C)alkyl, heterocyclyl, aryl, and (1-4C)alkyl [optionally substituted]; possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity. Processes for the manufacture of compounds and pharmaceutical compositions containing them are described.
• WO2006/82401
  申请人：——

  公开号：——

  公开（公告）日：——