[EN] GAMMA SECRETASE MODULATORS<br/>[FR] MODULATEURS DE LA GAMMA SÉCRÉTASE
申请人:SCHERING CORP
公开号:WO2009073777A1
公开(公告)日:2009-06-11
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R2 is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
This invention provides novel compounds that are modulators of gamma secretase. The compounds have the formula (I) wherein R
2
is a fused bicyclic ring of the formula (II). Also disclosed are methods of modulating gamma secretase activity and methods of treating Alzheimer's disease using the compounds of formula (I).
We herein report the discovery of four series of fused 5,6-bicyclic heterocycles as gamma-secretase modulators. Synthesis and SAR of these series are discussed. These compounds represent a new class of gamma-secretase modulators that demonstrate moderate to good in vitro potency in inhibiting A beta(42) production. (C) 2010 Elsevier Ltd. All rights reserved.