Boc-Arg(Mts)-OBzl | 139397-11-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Boc-Arg(Mts)-OBzl
• CAS: 139397-11-8
• 化学式: C₂₇H₃₈N₄O₆S
• 分子量: 546.688
• InChiKey: RPMQNRSMORQRSK-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.83
• 重原子数：
  38.0
• 可旋转键数：
  10.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  146.68
• 氢给体数：
  4.0
• 氢受体数：
  7.0

反应信息

• 作为反应物：
  描述：

  Boc-Arg(Mts)-OBzl 在 盐酸 、 二苯基磷酸 、 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 生成 dibenzyl (3-(((S)-1-(benzyloxy)-5-(3-(mesitylsulfonyl)guanidino)-1-oxopentan-2-yl)amino)-3-oxopropanoyl)-L-aspartate
  参考文献：
  名称：

  Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of arg-gly-asp (RGD)

  摘要：

  partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects on experimental lung metastasis of murine melanoma and adenosine 5'-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient therapeutic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00494-5
• 作为产物：
  描述：

  叔丁氧羰基-N'-(4-甲氧基-2,3,6-三甲基苯磺酰基)精氨酸环己基胺盐 、 溴甲苯 在 碳酸氢钠 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成 Boc-Arg(Mts)-OBzl
  参考文献：
  名称：

  Synthesis and biological properties of partially modified retro and retro-inverso pseudo peptides of arg-gly-asp (RGD)

  摘要：

  partially modified retro and retro-inverso peptide analogs of Arg-Gly-Asp (RGD) were synthesized and examined their inhibitory effects on experimental lung metastasis of murine melanoma and adenosine 5'-diphosphate (ADP) induced platelet aggregation. The analogs showed efficient therapeutic potency for the tumor metastasis but low inhibitory effect on ADP induced platelet aggregation. Copyright (C) 1996 Elsevier Science Ltd

  DOI：

  10.1016/s0960-894x(96)00494-5

文献信息

• Synthesis of the nonatetracontapeptide corresponding to the entire amino acid sequence of thymopoietin III and its effect on the impaired T-lymphocyte transformation of a patient with common variable immunodeficiency.
  作者：TAKASHI ABIKO、HIROSHI SHISHIDO、HIROSHI SEKINO

  DOI：10.1248/cpb.34.2133

  日期：——

  The nonatetracontapeptide corresponding to the entire amino acid sequence of thymopoietin III was synthesized by assembling ten peptide fragments in solution followed by deprotection with 1M trifluoromethanesulfonic acid-thioanisole (molar ratio, 1 : 1) in trifluoroacetic acid in the presence of m-cresol. The synthetic nonatetracontapeptide was tested for effect on impaired T-lymphocyte transformation by phytohemagglutinin (PHA) in common variable immunodeficiency.The synthetic nonatetracontapeptide was found to have restorin activity on the T-lymphocyte transformation by PHA. However, the restoring activity of the synthetic nonatetracontapeptide was lower than that of the synthetic thymopoietin I at a dos of 2 μg/ml.

  对应于胸腺生成素III整个氨基酸序列的非九十三肽，是通过溶液中组装十个肽片段，随后在间甲酚存在下用1M三氟甲磺酸-噻吩甲烷（摩尔比，1:1）在三氟乙酸中脱保护来合成的。合成的非九十三肽被测试了其在常见变异性免疫缺陷中对植物血凝素（PHA）诱导的受损T淋巴细胞转化的影响。发现合成的非九十三肽对PHA诱导的T淋巴细胞转化具有恢复活性。然而，合成的非九十三肽的恢复活性在2μg/ml剂量下低于合成胸腺生成素I的活性。