(E)-1-(2-(hexyloxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one | 1393845-26-5

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 直链 1,3-二芳基丙烷
• 英文名称: (E)-1-(2-(hexyloxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
• 英文别名: (E)-1-(2-hexoxy-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
• CAS: 1393845-26-5
• 化学式: C₂₁H₂₄O₄
• 分子量: 340.419
• InChiKey: UXQYKROESHBIKG-SDNWHVSQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  25
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  66.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,6-二羟基苯乙酮 在 盐酸 、 水 、 potassium carbonate 、 三氟乙酸 、 sodium iodide 、 potassium hydroxide 作用下， 以 甲醇 、 乙醇 、 水 、 乙腈 为溶剂， 生成 (E)-1-(2-(hexyloxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one
  参考文献：
  名称：

  A SAR study on a series of synthetic lipophilic chalcones as Inhibitor of transcription factor NF-κB

  摘要：

  To define the structural features responsible for the activity of 2,4-dihydroxy-6-isopentyloxychalcone, a newly established inhibitor of LPS induced NF-kappa B activation (IC50 = 10 mu M), a series of its analogues was prepared and studied for their in vitro activities against LPS induced NF-kappa B inhibition in RAW 264.7 cells. Among the synthesized derivatives, (E)-1-(2-(decyloxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (1050 = 2.7 mu M) and (E)-1-(2-hydroxy-6-(tetradecyloxy)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (IC50 = 4.2 mu M) showed the most potent inhibition. The SAR studies confirmed that the length (C-8-C-14) and C-6 position of linear alkyl chain of ring A is an important factor for the inhibitory activity. Hydroxyl group and its location at 4-position on ring B is also important for the inhibition. The alpha,beta-unsaturated ketone moiety appears as a crucial motif of chalcones for the activity. (C) 2012 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2012.05.019

文献信息

• Anti-proliferative effect of chalcone derivatives through inactivation of NF-κB in human cancer cells
  作者：Eeda Venkateswararao、Vinay K. Sharma、Jieun Yun、Youngsoo Kim、Sang-Hun Jung

  DOI：10.1016/j.bmc.2014.04.045

  日期：2014.7

  To investigate the anti-proliferative effect of NF-kappa B inhibitor, a series of analogs of (E)-1-(2-hydroxy-6-(isopentyloxy)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (5a) were prepared and evaluated for their NE-kappa B inhibition and anti-proliferative activity against various human cancer cell lines. Compounds (E)-1-(2-(3,3-dimethylbutoxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (5e) and (E)-4-(3-(2-(3,3-dimethylbutoxy)-6-hydroxyphenyl)-3-oxoprop-1-enyl)benzenesulfonamide (5p) showed good NF-kappa B inhibition as well as potent anti-proliferative activity. SAR studies showed that all the compounds with potent or moderate NF-kappa B inhibition displayed good anti-proliferative activity. All the analogs (5b-r) maintained a good correlation between their NE-kappa B inhibition and anti-proliferative activity though the extent is not directly proportional to each other. (C) 2014 Elsevier Ltd. All rights reserved.
• A SAR study on a series of synthetic lipophilic chalcones as Inhibitor of transcription factor NF-κB
  作者：Eeda Venkateswararao、Vinay K. Sharma、Ki-Cheul Lee、Niti Sharma、Sun-Hong Park、Youngsoo Kim、Sang-Hun Jung

  DOI：10.1016/j.ejmech.2012.05.019

  日期：2012.8

  To define the structural features responsible for the activity of 2,4-dihydroxy-6-isopentyloxychalcone, a newly established inhibitor of LPS induced NF-kappa B activation (IC50 = 10 mu M), a series of its analogues was prepared and studied for their in vitro activities against LPS induced NF-kappa B inhibition in RAW 264.7 cells. Among the synthesized derivatives, (E)-1-(2-(decyloxy)-6-hydroxyphenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (1050 = 2.7 mu M) and (E)-1-(2-hydroxy-6-(tetradecyloxy)phenyl)-3-(4-hydroxyphenyl)prop-2-en-1-one (IC50 = 4.2 mu M) showed the most potent inhibition. The SAR studies confirmed that the length (C-8-C-14) and C-6 position of linear alkyl chain of ring A is an important factor for the inhibitory activity. Hydroxyl group and its location at 4-position on ring B is also important for the inhibition. The alpha,beta-unsaturated ketone moiety appears as a crucial motif of chalcones for the activity. (C) 2012 Elsevier Masson SAS. All rights reserved.