Phenylacetursaeure-N-methylamid | 25439-28-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Phenylacetursaeure-N-methylamid
• 英文别名: N-[2-(methylamino)-2-oxoethyl]-2-phenylacetamide
• CAS: 25439-28-5
• 化学式: C₁₁H₁₄N₂O₂
• mdl: MFCD07293132
• 分子量: 206.244
• InChiKey: HURLMPVJXWNNDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.272
• 拓扑面积：
  58.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-[(2-苯基乙酰基)氨基]乙酸乙酯 、 甲胺 生成 Phenylacetursaeure-N-methylamid
  参考文献：
  名称：

  紫霉素。第二部分 发色团的结构

  摘要：

  显示出维霉素的发色单元是C-甲酰基甘氨酸的单脲，其存在于肽组合中。维霉素的氢解然后水解产生丙氨酸，丙氨酸不存在于维霉素水解产物中，其衍生自发色团。讨论了涉及生色团的紫霉素的其他反应。尿素轻度水解过程中尿素的释放速率显示出与生色团的损失速率相对应。不稳定的产品，去氨脲霉素，可以与尿素重新组合以重建抗生素。

  DOI：

  10.1039/p19720000827

文献信息

• Sulfonyl amide inhibitors of calcium channel function
  申请人：Hangeland J. Jon

  公开号：US20050245535A1

  公开（公告）日：2005-11-03

  Compounds of formula I its stereoisomers, solvates, and salts, thereof, wherein: a, b, c, d, f, n, m and Ra are defined herein are are inhibitors of calcium channel function, and are useful in treating calcium channel-dependent disorders, including hypertension.

  化合物I的立体异构体、溶剂合物和盐类，其中：a、b、c、d、f、n、m和Ra的定义如下，是钙通道功能的抑制剂，并且在治疗依赖于钙通道的疾病，包括高血压方面具有用处。
• PROCESS FOR PRODUCTION OF TABLETS CONTAINING BOTH CRYSTALLINE CELLULOSE AND GRANULES
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2184056A1

  公开（公告）日：2010-05-12

  A process for producing a granule-containing tablet comprising mixing more than 25 mass% to 89 mass% or less of crystalline cellulose exhibiting a tensile displacement at break of 25 to 80 µm and a relative fluidity index of 2.15 to 2.80 at a maximum compaction stress of 15 kPa, 10 to 70 mass% of spherical granules, and 20 mass% or less of a disintegrant, and then compressing the obtained mixture.

  一种含颗粒片剂的生产工艺，包括将 25 质量%以上至 89 质量%或以下的结晶纤维素、10 质量%至 70 质量%的球形颗粒和 20 质量%或以下的崩解剂混合在一起，在最大压实应力为 15 千帕时，其断裂拉伸位移为 25 至 80 微米，相对流动性指数为 2.15 至 2.80，然后压缩所得到的混合物。
• CELLULOSE FINE CORE PARTICLE, AND METHOD FOR PRODUCTION THEREOF
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2161036A1

  公开（公告）日：2010-03-10

  It is an object of the present invention to provide a fine core particle, which comprises a coating layer having a uniform thickness, and which can be used to produce, at a high yield, a small granule causing no sandy feeling in the oral cavity when the fine core particle is applied to a fine granule or an orally-disintegrating tablet. According to the present invention, there is provided a core particle, which comprises 50% by mass or more of microcrystalline cellulose, and which has a mean particle diameter of less than 100 µm, a relative flow index of 7.0 to 30.0, a specific surface area of less than 0.15 m2/g, and a tapped bulk density of 0.80 g/mL or more.

  本发明的目的是提供一种细芯颗粒，它包括厚度均匀的包衣层，当细芯颗粒应用于细颗粒或口腔崩解片时，可用于高产率地生产在口腔中无沙粒感的小颗粒。根据本发明，提供了一种芯颗粒，它由 50%或更多质量的微晶纤维素组成，其平均颗粒直径小于 100 µm，相对流动指数为 7.0 至 30.0，比表面积小于 0.15 m2/g，以及 0.80 g/mL 或更大的堆积密度。
• ORALLY DISINTEGRATING TABLET CONTAINING BITTERNESS-MASKING GRANULES
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2810659A1

  公开（公告）日：2014-12-10

  Disclosed is a tablet containing anhydrous calcium hydrogen phosphate, granules (A) which contain sugars, and granules (B) which contain nuclear particles having a diameter of 10-500µm, medicine and a film coating, and which have a particle diameter of 700µm or less. The present invention enables tablet-making difficulties during the manufacture of the tablet to be suppressed. In addition, the tablet has an appropriate hardness, an excellent disintegration time, and feels very good to ingest.

  本发明公开了一种片剂，它含有无水磷酸氢钙、含有糖的颗粒（A）和含有直径为 10-500µm 的核颗粒、药物和薄膜包衣的颗粒（B），且颗粒直径小于等于 700µm。本发明能够抑制片剂制造过程中的制片困难。此外，片剂具有适当的硬度和极佳的崩解时间，且服用感非常好。
• CELLULOSE MICROPOWDER
  申请人：ASAHI KASEI KABUSHIKI KAISHA

  公开号：EP3181616A1

  公开（公告）日：2017-06-21

  The present invention relates to a cellulose powder usable for a satisfactory orally disintegrating tablet having excellent compression moldability and well-balanced tablet moldability and disintegration properties, which can obtain excellent ingestion feel without feeling roughness and dryness in the oral cavity, and more particularly to a cellulose powder with an average polymerization degree of 150 to 450, an average particle diameter of not less than 10 µm but less than 100 µm, and a primary particle ratio of 50% or more.

  本发明涉及一种可用于令人满意的口腔崩解片的纤维素粉末，它具有极佳的压缩成型性和均衡的片剂成型性和崩解性，可获得极佳的摄取感，在口腔中不会感到粗糙和干燥，特别是涉及一种平均聚合度为 150 至 450、平均颗粒直径不小于 10 微米但小于 100 微米、初级颗粒比率为 50%或以上的纤维素粉末。