Lys(Gly) | 1191-22-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Lys(Gly)
• 英文别名: N^ε-Glycyl-L-lysin；ε-Glycin-lysin；N⁶-glycyl-L-lysine；N⁶-Glycyl-L-lysin；Glycyl-isolysine；(2S)-2-amino-6-[(2-aminoacetyl)amino]hexanoic acid
• CAS: 1191-22-6
• 化学式: C₈H₁₇N₃O₃
• 分子量: 203.241
• InChiKey: YOYBPHLYMUAKGZ-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  118
• 氢给体数：
  4
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  Nα-Carbobenzoxy-Nε-(carbobenzoxy-glycyl)-L-lysin-benzylester 在 palladium on activated charcoal 盐酸 、 氢气 作用下， 以 乙醇 、 溶剂黄146 为溶剂， 生成 Lys(Gly)
  参考文献：
  名称：

  On the Peptides of L-Lysine^1,2

  摘要：

  DOI：

  10.1021/ja01464a043

文献信息

• Automated identification of peptides
  申请人：——

  公开号：US20020102610A1

  公开（公告）日：2002-08-01

  A fully automated, user-independent method is described for computer-mediated interpretation of data derived by mass spectrometry of an experimental peptide to identify and characterize a corresponding peptide sequence in a peptide database. The method identifies the corresponding sequence if it is present in the database, without the need for a skilled observer to choose from amongst a list of possible matches. By using an automated back-read process, the present method can uniquely identify a corresponding peptide sequence in a database based on a single matching peptide sequence. The method also permits mapping of mass spectral data to sequences in peptide or nucleotide databases for unambiguous identification of exons; determining a correct reading frame; identifying artefacts and errors in sequences; identifying mutations and polymorphisms; identifying post-translational modifications; and identifying exon-intron boundaries.

  本文描述了一种完全自动化、不依赖用户的方法，用于通过质谱技术获得的实验性肽段数据的计算机介导解释，以识别和表征相应的肽段序列在肽段数据库中的对应关系。该方法可以在不需要熟练的观察者从可能匹配的列表中选择的情况下，识别出数据库中存在的相应序列。通过使用自动化的反向读取过程，本方法可以基于单个匹配的肽段序列，在数据库中唯一地识别相应的肽段序列。该方法还允许将质谱数据映射到肽或核苷酸数据库中的序列，以明确识别外显子；确定正确的阅读框架；识别序列中的工件和错误；识别突变和多态性；识别后翻译修饰；以及识别外显子-内含子边界。
• Detection of peptides
  申请人：Millipore Corporation

  公开号：EP2128619A1

  公开（公告）日：2009-12-02

  A method for determining the presence of one or more proteins of interest in a sample, which method comprises the step of: c) submitting the sample to conditions that allow fragmentation of the protein into target peptide fragments; and d) contacting the target peptide fragments with an array of capture agents immobilized on a solid support, the capture agents comprising those that recognize a target protein fragment; whereby the binding of the target peptide fragments with the capture agents is indicative of the presence of the protein(s) in the sample. A device comprising such an array, and its production, are also described.

  一种确定样品中是否存在一种或多种相关蛋白质的方法，该方法包括以下步骤：c) 将样品置于可将蛋白质破碎成目标肽片段的条件下；d) 将目标肽片段与固定在固体支持物上的捕获剂阵列接触，捕获剂包括可识别目标蛋白质片段的捕获剂；目标肽片段与捕获剂的结合表明样品中存在蛋白质。此外，还介绍了一种包含这种阵列的装置及其生产方法。
• HUMAN TRANSFERRIN RECEPTOR BINDING PEPTIDE
  申请人：JCR Pharmaceuticals Co., Ltd.

  公开号：EP4108676A1

  公开（公告）日：2022-12-28

  [Problem] To provide a peptide, etc., capable of passing through the blood-brain barrier (BBB) by binding to a human transferrin receptor (hTfR). [Solution] A peptide, etc., having the amino acid sequence shown in SEQ ID NO: 1 (Ala-Val-Phe-Val-Trp-Asn-Tyr-Tyr-Ile-Ile-Ser-Cys) or an amino acid sequence having substitutions, deletions, additions, and/or insertions of 1 to 10 amino acid residues (inclusive) in the amino acid sequence shown in SEQ ID NO: 1.

  [问题]提供一种能够通过与人转铁蛋白受体（hTfR）结合而通过血脑屏障（BBB）的多肽等。[解决方案]一种多肽等，具有 SEQ ID NO: 1 所示的氨基酸序列（Ala-Val-Phe-Val-Trp-Asn-Tyr-Tyr-Ile-Ile-Ser-Cys）或在 SEQ ID NO: 1 所示的氨基酸序列中具有 1 至 10 个氨基酸残基（含）的取代、缺失、添加和/或插入的氨基酸序列。
• Cell lines
  申请人：MEDIMMUNE LIMITED

  公开号：US10253345B2

  公开（公告）日：2019-04-09

  There is provided inter alia a process for stabilizing a eukaryotic cell line which expresses PylRS and tRNAPyl and which is suitable for incorporation of a gene encoding a target protein containing one or more non-natural amino acids encoded by a nonsense codon which comprises culturing said cell line under conditions in which the adverse effect of tRNAPyl expression on cell viability and/or cell growth is reduced or eliminated.

  除其他外，还提供了一种稳定真核细胞系的方法，该细胞系表达 PylRS 和 tRNAPyl，适于加入编码含有一个或多个由无意义密码子编码的非天然氨基酸的目标蛋白质的基因，该方法包括在减少或消除 tRNAPyl 表达对细胞活力和/或细胞生长的不利影响的条件下培养所述细胞系。
• Methods of treating volume depletion and kidney injury
  申请人：THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK

  公开号：US11119104B2

  公开（公告）日：2021-09-14

  The present invention provides methods for treatment of volume-dependent Acute Kidney Injury (vAKI) and ischemic Acute Kidney Injury (iAKI), as well as methods for diagnosing vAKI and iAKI. The methods are based on determining the levels of PAPPA2, NGAL, KRT20, or TACSTD2 protein in a sample from a patient, such as a urine sample. The present invention also provides a device and a diagnostics kit for determining whether a sample from a subject contains PAPPA2, NGAL, KRT20, or TACSTD2 protein.

  本发明提供了治疗容量依赖性急性肾损伤（vAKI）和缺血性急性肾损伤（iAKI）的方法，以及诊断vAKI和iAKI的方法。这些方法基于测定患者尿样等样本中的 PAPPA2、NGAL、KRT20 或 TACSTD2 蛋白水平。本发明还提供了一种设备和诊断试剂盒，用于确定受试者样本中是否含有 PAPPA2、NGAL、KRT20 或 TACSTD2 蛋白质。