(+/-)-3,4,5,6-Tetramethyl-9,10-phenanthrenequinone | 17825-40-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 菲及其衍生物
• 英文名称: (+/-)-3,4,5,6-Tetramethyl-9,10-phenanthrenequinone
• 英文别名: NSC 135880；3,4,5,6-tetramethylphenanthrene-9,10-dione
• CAS: 17825-40-0；138488-74-1；138488-75-2
• 化学式: C₁₈H₁₆O₂
• 分子量: 264.324
• InChiKey: JTMGCXDRWXHOND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  34.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (+/-)-3,4,5,6-Tetramethyl-9,10-phenanthrenequinone 在 钾硼氢 、 氧气 作用下， 生成 3,4,5,6-tetramethyl-9,10-dihydroxy-9,10-dihydrophenanthrene 、 3,4,5,6-tetramethyl-9,10-dihydroxy-9,10-dihydrophenanthrene
  参考文献：
  名称：

  Kinetically stable conformers of 3,4,5,6-tetramethyl-9,10-dihydroxy-9,10-dihydrophenanthrene as probes of the conformer specificity of UDPglucuronosyltransferase

  摘要：

  DOI：

  10.1021/ja00290a051
• 作为产物：
  描述：

  (+/-)-5,5',6,6'-tetramethyldiphenic acid 在 水 、 sodium 、 氢气 作用下， 以 甲苯 为溶剂， 生成 (+/-)-3,4,5,6-Tetramethyl-9,10-phenanthrenequinone
  参考文献：
  名称：

  Fritsch, Rainer; Hartmann, Erwin; Andert, Doris, Chemische Berichte, 1992, vol. 125, # 4, p. 849 - 856

  摘要：

  DOI：

文献信息

• Stereoselective Synthesis Axially Chiral Arylnitriles through Base-Induced Chirality-Relay β-Carbon Elimination of α-Hydroxyl Ketoxime Esters
  作者：Xue Zhang、Xiaoping Xue、Zhenhua Gu

  DOI：10.1021/acs.orglett.3c00805

  日期：2023.5.26

  We report herein a point-to-axial chirality transfer reaction of α-hydroxyl oxime esters for the synthesis of axially chiral arylnitriles. The reaction proceeds smoothly through a base-promoted retro-benzoin condensation reaction of α-hydroxyl oxime esters, where the axial chirality is created via the C–C bond cleavage based on a proper distorted conformation of the biaryl structure induced by its

  我们在此报告了用于合成轴向手性芳基腈的 α-羟基肟酯的点到轴向手性转移反应。该反应通过 α-羟基肟酯的碱促进逆安息香缩合反应顺利进行，其中轴向手性是通过 C-C 键断裂产生的，基于其立体异构碳中心诱导的联芳基结构的适当扭曲构象.
• Synthesis and polarographic reduction of strained phenanthrenequinones. The buttressing effect
  作者：Harold A. Karnes、M. L. Rose、Justin W. Collat、Melvin S. Newman

  DOI：10.1021/ja01004a042

  日期：1968.1
• NEWMAN M. S.; LILJE K. C., J. ORG. CHEM., 1979, 44, NO 26, 4944-4946
  作者：NEWMAN M. S.、 LILJE K. C.

  DOI：——

  日期：——
• CD45 and Methods and Compounds Related Thereto
  申请人：Panchal Rekha

  公开号：US20120135013A1

  公开（公告）日：2012-05-31

  Disclosed herein are compounds, compositions and methods for preventing, reducing or inhibiting an amount of protein tyrosine phosphatase receptor type C (CD45) expressed or activity of CD45 in a cell or a subject. Also disclosed are methods for preventing, inhibiting or treating an infection in a cell or a subject immunizing a subject or enhancing a subject's immune response against an infection preventing, reducing or inhibiting the susceptibility of a cell or a subject to an infection or subsequent pathogenesis and morbidity due to the infection and preventing, reducing, and inhibiting apoptosis caused by or resulting from a biological agent in a cell or a subject which comprises preventing, reducing or inhibiting an amount of protein tyrosine phosphatase receptor type C (CD45) expressed or activity of CD45 in the cell or the subject.
• Methods for Inhibiting Virus Replication
  申请人：UNIVERSITY OF GEORGIA RESEARCH FOUNDATION, INC.

  公开号：US20140121237A1

  公开（公告）日：2014-05-01

  The present invention provides methods for treating a subject having, or at risk of having, a viral infection. The methods include, but are not limited to, the use of 4-(dipropylsulfamoyl)benzoic acid, an inhibitor of CDC25B phosphatase, an inhibitor of ICAM-1, an inhibitor of CamK2B, or a combination thereof.