tris(3,5-dimethylphenyl)phosphine oxide | 381212-20-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tris(3,5-dimethylphenyl)phosphine oxide
• 英文别名: 1-bis(3,5-dimethylphenyl)phosphoryl-3,5-dimethylbenzene
• CAS: 381212-20-0
• 化学式: C₂₄H₂₇OP
• 分子量: 362.452
• InChiKey: XHPUAFDIDTVXKX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.2
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  tris(3,5-dimethylphenyl)phosphine oxide 在 2,6-二甲基吡啶 、 草酰氯 、 氢气 、 tris(2,6-difluorophenyl)borane 作用下， 以 氘代甲苯 为溶剂， 130.0 ℃ 、400.01 kPa 条件下， 反应 2.0h， 以56%的产率得到三(3,5-二甲苯基)膦
  参考文献：
  名称：

  使用草酰氯和氢气还原亲电性磷阳离子介导的氧化膦

  摘要：

  使用草酰氯作为活化剂，实现了以分子氢（H 2）对金属氧化物氧化物的无金属还原。量子力学研究支持通过原位形成的亲电phospho阳离子（EPC）和氧化膦进行H 2的杂化裂解，以及随后的无阻转化为膦和HCl。该反应还可以通过由B（2,6-F 2 C 6 H 3）3和2,6-二甲基吡啶或氧化膦作为Lewis碱组成的沮丧Lewis对（FLP）催化。三芳基和二芳基氧化膦证明了这种新颖的还原方法，提供了以良好至极佳收率（51％至93％）的膦原子。

  DOI：

  10.1002/anie.201809275
• 作为产物：
  描述：

  3,5-二甲基溴苯 在 双氧水 、 magnesium 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 21.0h， 生成 tris(3,5-dimethylphenyl)phosphine oxide
  参考文献：
  名称：

  一种新的二甲苯基-二芳基二膦配体的简明合成，用于酮的不对称加氢

  摘要：

  描述了在磷上带有3，5-二甲基苯基取代基的对称联芳基二膦配体的简明合成。发现含有新的配体Xyl-TetraPHEMP的钌催化剂[二膦RuCl 2二胺]与用于均相不对称酮氢化的最新催化剂一样具有活性和选择性。

  DOI：

  10.1016/s0040-4039(03)00940-7
• 作为试剂：
  描述：

  甲基苯乙烯 在 cationic chromium oxo salen 、 tris(3,5-dimethylphenyl)phosphine oxide 作用下， 以 乙腈 为溶剂， 生成 1-苯基-1,2-环氧丙烷 、 1(1R,2R)-(+)-1-苯基亚丙基环氧
  参考文献：
  名称：

  Asymmetric alkene epoxidation with chromium oxo salen complexes. Effect of added phosphoryl ligands

  摘要：

  In the stoichiometric asymmetric epoxidation of E-beta-methylstyrene with cationic chromium-salen oxo complexes, enantioselectivity is elevated by the addition of many different types of phosphoryl compounds. Triarylphosphine oxides are the most effective. and, amongst them,, tris(3,5-dimethylphenyl)phosphine oxide gave the highest ee to date (93%). There is a ceiling effect of additive. bulky additives are ineffective, there is no substituent electronic effect within the additive and there is a saturation of its effect with increasing concentration. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(02)00193-4

文献信息

• Chiral ligands for asymmetric catalysis
  申请人：Malan Guillaume Christophe

  公开号：US20050043556A1

  公开（公告）日：2005-02-24

  The present invention is based around the discoveries that novel ligands of formula (4) and the opposite enantiomers thereof, (i) have utility as components of catalysts for asymmetric hydrogenation and (ii) are readily accessible by an efficient general synthetic route. In particular, ruthenium-diamine complexes of the ligands (4) are highly active and selective catalysts for the asymmetric hydrogenation of ketones.

  本发明基于发现，公式（4）的新型配体及其对映异构体具有以下用途：（i）作为不对称氢化反应催化剂的组分，（ii）可通过高效的通用合成途径轻松获得。特别是，配体（4）的铼-二胺配合物是高活性和选择性的酮的不对称氢化反应催化剂。
• Cellulose Compound Film, Optical Compensation Sheet, Polarizing Plate, and Liquid Crystal Display Device
  申请人：Nozoe Yutaka

  公开号：US20070259134A1

  公开（公告）日：2007-11-08

  A cellulose compound film containing a cellulose compound having two or more substituents whose polarizability anisotropies Δα calculated by mathematical formula (1) are different from each other, wherein substitution degrees of the following substituents A and B in the cellulose compound satisfy relationship as defined by mathematical formula (A1), in which the substituent A has the lowest Δα and the substituent B has the highest Δα: Δ ⁢ ⁢ α = α ⁢ ⁢ x - α ⁢ ⁢ y + α ⁢ ⁢ z 2 Mathematical ⁢ ⁢ formula ⁢ ⁢ ( 1 ) wherein, in characteristic values obtained after diagonalization of polarizability tensor, αx is the largest component, αy is the second largest component, and αz is the smallest component; DS B 2+ DS B 3− DS B 6≧−0.1   Mathematical formula (A1) wherein DS B 2, DS B 3, and DS B 6 represent a substitution degree of the substituent B at the 2-, 3-, or 6-position of a β-glucose ring constituting unit of cellulose, respectively; and an optical compensation film, a polarizing plate, and a liquid crystal display device, using the cellulose compound film.

  一种纤维素化合物薄膜，其含有具有两个或更多取代基的纤维素化合物，其极化率各向异性Δα通过数学公式（1）计算得出，其中以下取代基A和B的取代度满足数学公式（A1）所定义的关系，其中取代基A具有最低的Δα，而取代基B具有最高的Δα：Δα = αx-αy + αz2数学公式（1）其中，在极化率张量对角化后获得的特征值中，αx是最大分量，αy是第二大分量，αz是最小分量;DSB2 + DSB3-DSB6≥-0.1数学公式（A1）其中DSB2、DSB3和DSB6分别表示取代基B在纤维素构成单位β-葡萄糖环的2-、3-或6-位置的取代度;以及使用该纤维素化合物薄膜的光学补偿膜、偏光板和液晶显示装置。
• Immunoassay method
  申请人：Ohzeki Katsuhisa

  公开号：US20080145869A1

  公开（公告）日：2008-06-19

  The present invention provides a method for immunoassaying an object to be analyzed including: causing to act, on a specimen or a sample including the specimen, a first protein (Y), which can specifically recognize the object to be analyzed in the specimen and is modified by a labeling substance, so as to form a complex including the object to be analyzed and Y; and measuring the labeling substance contained in the complex or the labeling substance contained in the free protein (Y), wherein the measurement of the labeling substance is performed by a chemiluminescent method which includes sensing the light generated by chemiluminescence using a photothermographic material including at least an organic silver salt, a reducing agent for silver ions and a photosensitive silver halide to form a latent image, and making the latent image visible by thermal development. An easy, quick, and highly precise immunoassay method is provided.

  本发明提供了一种免疫分析待分析物的方法，包括：在含有待分析物的样本或标本上作用第一蛋白（Y），该蛋白可以特异性地识别标本中的待分析物并被标记物质改性，以形成包括待分析物和Y的复合物；并测量复合物中包含的标记物质或自由蛋白（Y）中包含的标记物质。其中，标记物质的测量是通过化学发光法进行的，该法包括使用至少含有有机银盐、银离子还原剂和感光银卤化物的光热材料来感应化学发光所产生的光，并通过热发展使潜像可见。提供了一种简单、快速、高精度的免疫分析方法。
• Cellulose Acylate Film, Method of Producing the Same, Cellulose Derivative Film, Optically Compensatory Film Using the Same, Optically-Compensatory Film Incorporating Polarizing Plate, Polarizing Plate and Liquid Crystal Display Device
  申请人：Haruta Hiromoto

  公开号：US20090290100A1

  公开（公告）日：2009-11-26

  A method of producing a cellulose derivative film, the method comprising: forming a film with a solvent cast method from a dope including a cellulose derivative satisfying following conditions (a) and (b): (a) at least one among three hydroxyl groups included in a glucose unit of cellulose is substituted by a substituent of which a polarizability anisotropy Δα represented as following Expression (1) is 2.5×10 −24 cm 3 or higher: Expression (1): Δα=αx−(αy+αz)/2, wherein αx, αy and αz is as defined in the specification; and (b) when a substitution degree by a substituent of which Δα is 2.5×10 −24 cm 3 or higher is P A , and a substitution degree by a substituent of which Δα is lower than 2.5×10 −24 cm 3 is P B , the P A and P B satisfy following Expressions (3) and (4): Expression (3): 2P A +P B >3.0; and Expression (4): P A >0.2.

  一种生产纤维素衍生物薄膜的方法，该方法包括：使用包括满足以下条件（a）和（b）的纤维素衍生物的溶胶，通过溶剂浇铸法形成薄膜：（a）纤维素的葡萄糖单元中的三个羟基中的至少一个被取代为极化率各向异性Δα（以下表达式（1）表示）为2.5×10-24cm3或更高的取代基：表达式（1）：Δα=αx-（αy+αz）/ 2，其中αx，αy和αz如规范中定义的；并且（b）当Δα为2.5×10-24cm3或更高的取代基的取代度为PA时，Δα低于2.5×10-24cm3的取代基的取代度为PB，PA和PB满足以下表达式（3）和（4）：表达式（3）：2PA + PB> 3.0；表达式（4）：PA> 0.2。
• CHIRAL LIGANDS FOR ASYMMETRIC CATALYSIS
  申请人：Chirotech Technology Limited

  公开号：EP1458731A1

  公开（公告）日：2004-09-22