O-(4-羟基-3,5-二碘苯基)-DL-酪氨酸 | 60363-25-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 中文名称: O-(4-羟基-3,5-二碘苯基)-DL-酪氨酸
• 英文名称: 3',5'-diiodothyronine
• 英文别名: 3',5'-Dijod-thyronin；2-Azaniumyl-3-[4-(4-hydroxy-3,5-diiodophenoxy)phenyl]propanoate
• CAS: 60363-25-9
• 化学式: C₁₅H₁₃I₂NO₄
• 分子量: 525.082
• InChiKey: LROTZSUGDZPWDN-UHFFFAOYSA-N

物化性质

• 熔点：
  207 °C
• 沸点：
  497.0±45.0 °C(Predicted)
• 密度：
  2.095±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  22
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  92.8
• 氢给体数：
  3
• 氢受体数：
  5

安全信息

• 海关编码：
  2922509090

反应信息

• 作为产物：
  描述：

  4-(3,5-diiodo-4-methoxy-phenoxy)-benzonitrile 在 盐酸 、 磷化氢 、 氯仿 、 氢碘酸 、 sodium acetate 、 次磷酸 、 乙酸酐 、 tin(ll) chloride 作用下， 生成 O-(4-羟基-3,5-二碘苯基)-DL-酪氨酸
  参考文献：
  名称：

  Genetic Population Structure and Origin of Life History Types in Chinook Salmon in British Columbia, Canada

  摘要：

  We used protein electrophoresis to examine genetic population structure and origin of life history types of chinook salmon Oncorhynchus tshawytscha in British Columbia, Canada. Among 31 allozyme loci resolved in 91 samples from 63 populations of chinook salmon in rivers and hatcheries throughout British Columbia, population heterozygosities averaged 0.084 (range 0.048-0.108) and were typical of values for populations in other regions. A hierarchical gene diversity analysis indicated that 91.3% of the total allele-frequency diversity was attributable to within-population variability; the remaining 8.7% was attributable to geographic variability among populations, which was partitioned into among-river (3.3%), among-area (3.5%), and among-region (1.9%) components. Two major groups of populations appeared in the principal components analysis and in cluster analysis of genetic distances. A coastal group included populations in four subgroups: Central coast, Georgia Strait, lower Fraser River, and west Vancouver Island. An inland group included six subgroups: Nass River, Skeena River, north Thompson River, upper and mid-Fraser River, south Thompson River, and lower Thompson River. The geographic extents of the inland and coastal groups largely coincided with the geographic distributions of stream- and ocean-type juvenile forms and may reflect postglacial colonization by two ancestral lineages that survived in Pleistocene refugia. The presence of genetically undifferentiated stream-type fish in coastal streams populated by ocean-type fish may reflect either postglacial life history differentiation from ancestral ocean-type fish or life history flexibility of ocean-type fish.

  DOI：

  10.1577/1548-8659(2000)129<0194:gpsaoo>2.0.co;2

文献信息

• Biosensing systems for measurement of lactose
  申请人：Reardon Kenneth F.

  公开号：US10024797B2

  公开（公告）日：2018-07-17

  Herein disclosed are biosensing systems that measure lactose concentration in a solution.

  这里公开的是测量溶液中乳糖浓度的生物传感系统。
• Methods, compositions and kits for providing a therapeutic treatment
  申请人：Ashur-Fabian Osnat

  公开号：US10398789B2

  公开（公告）日：2019-09-03

  The present invention encompasses a therapeutic method which employs treatment of a disease such as cancer with triiodothyronine (T3) together with an anti-thyroid treatment such as treatment with an anti-thyroid agent, treatment with radioiodine and surgical removal of all or part of the thyroid gland. A pharmaceutical composition comprising T3 and an anti-thyroid agent and a kit comprising the same are also encompassed by the invention.

  本发明包括一种治疗方法，该方法采用三碘甲状腺原氨酸（T3）治疗癌症等疾病，同时采用抗甲状腺治疗，如抗甲状腺药物治疗、放射性碘治疗和手术切除全部或部分甲状腺。本发明还包括由 T3 和抗甲状腺药剂组成的药物组合物以及由其组成的试剂盒。
• Roche et al., Bulletin de la Societe Chimique de France, 1957, p. 464,465
  作者：Roche et al.

  DOI：——

  日期：——
• Procédé de préparation des iodo-thyronines et des acides iodothyroacétiques par réduction électrochimique à potentiel contrôlé
  申请人：SPIRAL Société à responsabilité limitée dite :

  公开号：EP0093653B1

  公开（公告）日：1985-07-10
• EP1992341A1
  申请人：——

  公开号：EP1992341A1

  公开（公告）日：2008-11-19