Ethyl-cyclopentyl-malonsaeure-diethylester | 71691-57-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: Ethyl-cyclopentyl-malonsaeure-diethylester
• 英文别名: ethyl-cyclopentyl-malonic acid diethyl ester；Aethyl-cyclopentyl-malonsaeure-diaethylester；Diethyl 2-cyclopentyl-2-ethylmalonate；diethyl 2-cyclopentyl-2-ethylpropanedioate
• CAS: 71691-57-1
• 化学式: C₁₄H₂₄O₄
• 分子量: 256.342
• InChiKey: UZLCBQUVFHQGJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  Ethyl-cyclopentyl-malonsaeure-diethylester 在 sodium ethanolate 、 尿素 作用下， 生成 5-环戊基-5-乙基巴比妥酸
  参考文献：
  名称：

  US2019936

  摘要：

  公开号：
• 作为产物：
  描述：

  溴代环戊烷 、 Diethyl ethylsodiomalonate 在 乙醇 作用下， 生成 Ethyl-cyclopentyl-malonsaeure-diethylester
  参考文献：
  名称：

  US2019936

  摘要：

  公开号：

文献信息

• Catalytic reductive desymmetrization of malonic esters
  作者：Pengwei Xu、Zhongxing Huang

  DOI：10.1038/s41557-021-00715-0

  日期：2021.7

  carbons with a pair of enantiotopic functional groups is a practical strategy for the synthesis of quaternary stereocentres, as it divides the tasks of enantioselection and C−C bond formation. The use of disubstituted malonic esters as the substrate of desymmetrization is particularly attractive, given their easy and modular preparation, as well as the high synthetic values of the chiral monoester products

  具有一对对映体官能团的完全取代碳的去对称化是合成四元立体中心的实用策略，因为它划分了对映体选择和 C-C 键形成的任务。使用二取代丙二酸酯作为去对称化的底物特别有吸引力，因为它们易于制备和模块化，以及手性单酯产品的高合成价值。在这里，我们报告了具有四齿配体的双核锌配合物可以选择性地将丙二酸酯的羰基之一氢化硅烷化以产生 α-季铵 β-羟基酯，为使用羧酸酯酶的不对称水解提供了有希望的替代方案。不对称还原具有出色的对映控制，可以区分空间上相似的取代基和对底物二酯基序的高化学选择性。连同丙二酸酯底物的多功能制备和还原后衍生化，不对称还原使合成具有不同结构特征的多种季立体中心成为可能。
• METHOD FOR PRODUCING SOLID CATALYST COMPONENT FOR USE IN POLYMERIZATION OF OLEFIN, CATALYST FOR USE IN POLYMERIZATION OF OLEFIN, AND METHOD FOR PRODUCING OLEFIN POLYMER
  申请人：Toho Titanium CO., LTD.

  公开号：EP2876118A1

  公开（公告）日：2015-05-27

  A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity. The method includes a first step that brings a magnesium compound, a tetravalent titanium halide compound, and one or more first internal electron donor compounds selected from specific aromatic dicarboxylic diesters into contact with each other to effect a reaction, followed by washing, a second step that brings a tetravalent titanium halide compound and one or more second internal electron donor compounds into contact with a product obtained by the first step to effect a reaction, followed by washing, and a third step that brings one or more third internal electron donor compounds into contact with a product obtained by the second step to effect a reaction.

  一种生产烯烃聚合用固体催化剂组分的方法可生产出一种新型的烯烃聚合用固体催化剂组分，该组分具有优异的烯烃聚合活性和聚合过程中对氢的活性，并可生产出具有高MFR、高立体规整度和优异刚性的烯烃聚合物。该方法包括第一步，使镁化合物、四价卤化钛化合物和一种或多种选自特定芳香族二羧酸二酯的第一内部电子供体化合物相互接触以发生反应，然后进行洗涤、第二步：使四价卤化钛化合物和一种或多种第二内部电子供体化合物与第一步得到的产物接触，以发生反应，然后进行洗涤；第三步：使一种或多种第三内部电子供体化合物与第二步得到的产物接触，以发生反应。
• SOLID CATALYST COMPONENT FOR POLYMERIZATION OF OLEFINS, CATALYST FOR POLYMERIZATION OF OLEFINS, AND METHOD FOR PRODUCING OLEFIN POLYMER
  申请人：Toho Titanium CO., LTD.

  公开号：EP2902418A1

  公开（公告）日：2015-08-05

  A solid catalyst component for olefin polymerization makes it possible to polymerize an olefin with high polymerization activity when used for an olefin polymerization catalyst, and produce an olefin polymer having a low fine powder content, a low coarse powder content, and a low volatile organic compound (VOC) content in high yield. The solid catalyst component for olefin polymerization is produced by suspending (a) a dialkoxymagnesium, and (b) at least one alcohol selected from ethanol, n-propanol, n-butanol, isopropanol, isobutanol, and t-butanol, in an inert organic solvent so that the total amount of the alcohol is 0.5 to 1.5 parts by mass based on 100 parts by mass of the dialkoxymagnesium, to prepare a suspension, and bringing (c) an internal electron donor and (d) a titanium halide compound into contact with the suspension.

  一种用于烯烃聚合的固体催化剂组分可使烯烃聚合催化剂具有较高的聚合活性，并能高产率地生产出细粉含量低、粗粉含量低和挥发性有机化合物（VOC）含量低的烯烃聚合物。用于烯烃聚合的固体催化剂组分是通过在惰性有机溶剂中悬浮 (a) 二羰基镁和 (b) 至少一种选自乙醇、正丙醇、正丁醇、异丙醇、异丁醇和正丁醇的醇，使醇的总量为 0.5 至 1.5 质量份（以 100 质量份的二烷氧基镁为基准），以制备悬浮液，并使(c) 内部电子供体和(d) 卤化钛化合物与悬浮液接触。
• PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, CATALYST FOR POLYMERIZING OLEFINS, AND PRODUCTION METHOD FOR POLYMERIZED OLEFINS
  申请人：TOHO TITANIUM CO., LTD.

  公开号：EP2963063A1

  公开（公告）日：2016-01-06

  A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity. The method includes a first step that brings a magnesium compound, a tetravalent titanium halide compound, and one or more first internal electron donor compounds excluding an aromatic dicarboxylic acid diester into contact with each other to effect a reaction, followed by washing; a second step that brings a tetravalent titanium halide compound and one or more second internal electron donor compounds into contact with a product obtained by the first step to effect a reaction, followed by washing; and a third step that brings one or more third internal electron donor compounds into contact with a product obtained by the second step to effect a reaction.

  一种生产烯烃聚合用固体催化剂组分的方法可生产出一种新型的烯烃聚合用固体催化剂组分，该组分具有优异的烯烃聚合活性和聚合过程中对氢的活性，并可生产出具有高MFR、高立体规整度和优异刚性的烯烃聚合物。该方法包括第一步，使镁化合物、四价卤化钛化合物和一种或多种第一内部电子供体化合物（不包括芳香族二羧酸二酯）相互接触以发生反应，然后进行洗涤；第二步，使四价卤化钛化合物和一种或多种第二内部电子供体化合物与第一步得到的产物接触，以发生反应，然后进行洗涤；以及第三步，使一种或多种第三内部电子供体化合物与第二步得到的产物接触，以发生反应。
• CATALYST FOR OLEFIN POLYMERIZATION, METHOD FOR PRODUCING OLEFIN POLYMER, AND PROPYLENE/ -OLEFIN COPOLYMER
  申请人：Toho Titanium Co., Ltd.

  公开号：EP3623393A1

  公开（公告）日：2020-03-18

  Provided is a catalyst for polymerization of an olefin which can prepare, with high productivity, a polymer having excellent hydrogen activity and high stereoregularity and MFR even in homopolymerization at a high temperature, and is also capable of producing a copolymer that achieves excellent hydrogen activity and copolymerization activity even in copolymerization at a high temperature and is excellent in impact resistance. The present invention provides a catalyst for polymerization of an olefin, comprising a compound represented by the general formula R1R2Si(NHR3)2 wherein R1 is a cycloalkyl group having 3 to 12 carbon atoms or an aromatic hydrocarbon group having 6 to 12 carbon atoms; R2 is a linear alkyl group having 1 to 10 carbon atoms or a branched alkyl group having 3 to 10 carbon atoms; the number of carbon atoms of R1 is larger by 2 or more than that of R2; and R3 is a linear alkyl group having 2 to 6 carbon atoms, a branched alkyl group having 3 to 6 carbon atoms or a cycloalkyl group having 3 to 6 carbon atoms, as an external electron-donating compound.

  本发明提供了一种用于烯烃聚合的催化剂，它能以高生产率制备即使在高温下均聚时也具有优异氢活性和高立体规整度及MFR的聚合物，还能制备即使在高温下共聚时也具有优异氢活性和共聚活性以及优异抗冲击性的共聚物。本发明提供了一种用于烯烃聚合的催化剂，包括通式 R1R2Si(NHR3)2 所代表的化合物 其中 R1 是具有 3 至 12 个碳原子的环烷基或具有 6 至 12 个碳原子的芳香烃基；R2 是具有 1 至 10 个碳原子的直链烷基或具有 3 至 10 个碳原子的支链烷基；R1 的碳原子数比 R2 的碳原子数多 2 个或 2 个以上；以及 R3 是具有 2 至 6 个碳原子的直链烷基、具有 3 至 6 个碳原子的支链烷基或具有 3 至 6 个碳原子的环烷基，作为外部电子供体化合物。