(N,N'-ethylenediaminediacetato)cobalt(II) | 29977-10-4

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (N,N'-ethylenediaminediacetato)cobalt(II)
• 英文别名: [[N,Na(2)-1,2-Ethanediylbis[glycinato-I masculineN,I masculineO]](2-)]cobalt；2-[2-(carboxylatomethylamino)ethylamino]acetate;cobalt(2+)
• CAS: 29977-10-4
• 化学式: C₆H₁₀N₂O₄*Co
• 分子量: 233.15
• InChiKey: WEZLCHAXGMDHJP-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  -4.34
• 重原子数：
  13.0
• 可旋转键数：
  7.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  104.32
• 氢给体数：
  2.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  (N,N'-ethylenediaminediacetato)cobalt(II) 、 β-丙氨酸 以 水 为溶剂， 以17%的产率得到s-cis-mer-(N,N'-ethylenediaminediacetato)(β-alaninato)cobalt(III)
  参考文献：
  名称：

  含有四齿配体的电中性八面体钴 (III) 配合物的合成、表征和光学分辨率

  摘要：

  已经合成并表征了 [Co(edda)(aa)] 的三种几何异构体，其中 edda=N',N-乙二胺二乙酸根、aa=glycinato (gly)、β-alaninato (β-ala)。除了 unsym-cis-fac-[Co(edda)(β-ala)] 外，它们已被双（μ-d-酒石酸）二锑酸根（III）阴离子完全分解为对映体，[Sb2(d-tart )2]2-, 以水为洗脱液的 QAE-Sephadex 树脂形式，其绝对构型已根据圆二色光谱确定。已经表明，与 Λ 对映体相比，[Sb2(d-tart)2]2- 更倾向于 Δ 对映体，而与几何异构体的种类无关。已经提出了对光学分辨率机制的考虑。

  DOI：

  10.1246/bcsj.60.525

文献信息

• Kinetics of the interaction of some cobalt(II) chelates with air oxygen: formation of two-nitrogen oxygen carriers
  作者：Milan Strašák、Jaromír Kaválek

  DOI：10.1016/0304-5102(90)85200-2

  日期：1990.7

  reversible uptake of air oxygen in aqueous solution by cobalt(II) chelates of amino acid derivatives EBAA∗∗ have been examined. Kinetic data support the mechanism reported by Wilkins [1]. Enthalpies and entropies of activation have been determined from the temperature dependence of the rate constant k1 for the oxygenation reaction CoL + O2→CoLO2. The favorable enthalpy of oxygen binding is almost entirely

  研究了氨基酸衍生物EBAA ***的钴（II）螯合物可逆吸收水溶液中空气氧的热力学和动力学。动力学数据支持Wilkins [1]报道的机理。已经根据氧合反应CoL + O 2 →CoLO 2的速率常数k 1的温度依赖性确定了活化的焓和熵。不利的熵项几乎完全抵消了氧结合的有利焓。讨论了这些实验常数之间的关系，配合物的电子结构以及根据早期研究得出的结果的意义。
• N-hydroxymethylation of ethylene-bridged glycine metal(II) complexes by formaldehyde
  作者：Chew-Hee Ng、Soon-Beng Teo、Siang-Guan Teoh、Hoong-Kun Fun、Jean-Paul Declercq

  DOI：10.1016/s0020-1693(02)01092-7

  日期：2002.11

  The (N,N'-ethylenediglycinato)metal(II) complexes, M(edg) (M = Cu, Zn, Ni, Co) undergo N-hydroxymethylation with formaldehyde in the pH range similar to3.5-9.5 to yield the respective [N,N'-ethylenedi(N-hydroxymethyl-glycinato)]metal(II), ML x H2O (L = N,N'-ethylenedi(N-hydroxymethylglycinate); x = 4, 4.5). The crystal and molecular structures of the Ni(edg) 3H(2)O and ML 4H(2)O (M = Ni, Cu, Co) complexes have been determined; all the complexes have distorted octahedral geometries and their tetradentate ligands have oc-cis configuration. Analysis of these structures also shows that the N-hydroxymethylated ligands are stereospecifically coordinated. However, M(edg) do not undergo Mannich ammomethylation with formaldehyde and ammonia. In the reactions studied, the alpha-carbon of M(edg) is unaffected by formaldehyde attack. No further condensation of the N-hydroxymethyl substituents and their potential reactivity are also explained. (C) 2002 Elsevier Science B.V. All rights reserved.