9-phenylsulfonyl-4-hydroxycarbazole-3-carbaldehyde | 1158785-49-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 9-phenylsulfonyl-4-hydroxycarbazole-3-carbaldehyde
• 英文别名: 9-phenylsulfonyl-4-hydroxycarbazole-3-carboxaldehyde；9-(Benzenesulfonyl)-4-hydroxycarbazole-3-carbaldehyde；9-(benzenesulfonyl)-4-hydroxycarbazole-3-carbaldehyde
• CAS: 1158785-49-9
• 化学式: C₁₉H₁₃NO₄S
• 分子量: 351.383
• InChiKey: LRMGQXDNXRWUIT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  84.8
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  ethyl 1-phenylsulfonyl-2-phenylsulfinylmethylindole-3-carboxylate 、 丙烯醛 在 potassium tert-butylate 作用下， 以 四氢呋喃 为溶剂， 以64%的产率得到9-phenylsulfonyl-4-hydroxycarbazole-3-carbaldehyde
  参考文献：
  名称：

  Synthesis of di-, tri-, and tetra-substituted carbazole analogs involving annulation methodology

  摘要：

  Synthesis of substituted carbazole analogs was achieved via Michael addition followed by intramolecular cyclization and subsequent aromatization. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2009.03.009

文献信息

• An Improved Synthesis of Carbazoles<i>via</i>Domino Reaction of<i>N</i>-Protected-2-methylindoles with DMF-DMA/DMA-DMA
  作者：Radhakrishnan Sureshbabu、Arasambattu K. Mohanakrishnan

  DOI：10.1002/jhet.899

  日期：2012.7

  An efficient synthesis of carbazole analogs has been achieved via interaction of N‐protected‐2‐methylindoles with N,N‐dimethylformamide dimethylacetal as well as N,N‐dimethylacetamide dimethylacetal in the presence of pyrrolidine or 1,4‐diazabicyclo(2.2.2)octane (DABCO).
• Synthesis of di-, tri-, and tetra-substituted carbazole analogs involving annulation methodology
  作者：Neelamegam Ramesh、Ganesan Gobi Rajeshwaran、Arasambattu K. Mohanakrishnan

  DOI：10.1016/j.tet.2009.03.009

  日期：2009.5

  Synthesis of substituted carbazole analogs was achieved via Michael addition followed by intramolecular cyclization and subsequent aromatization. (C) 2009 Elsevier Ltd. All rights reserved.