α-Hydroxy-buttersaeure-diethylamid | 90227-19-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: α-Hydroxy-buttersaeure-diethylamid
• 英文别名: 2-Hydroxy-buttersaeure-diethylamid；N,N-diethyl-2-hydroxybutanamide
• CAS: 90227-19-3
• 化学式: C₈H₁₇NO₂
• 分子量: 159.228
• InChiKey: PYQPGXOMIBKINS-UHFFFAOYSA-N

物化性质

• 沸点：
  119-121 °C(Press: 15 Torr)
• 密度：
  0.977±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  α-Hydroxy-buttersaeure-diethylamid 、 ethyl 4-((2S)-5-tert-butoxy-2-([(4-hydroxy-6-phenylpyridin-2-yl)carbonyl]amino)-5-oxopentanoyl)piperazine-1-carboxylate 在 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 为溶剂， 生成
  参考文献：
  名称：

  Piperazinyl-glutamate-pyridines as potent orally bioavailable P2Y12 antagonists for inhibition of platelet aggregation

  摘要：

  Polymer-assisted solution-phase (PASP) parallel library synthesis was used to discover a piperazinyl-glutamate-pyridine as a P2Y(12) antagonist. Exploitation of this lead provided compounds with excellent inhibition of platelet aggregation as measured in a human platelet rich plasma (PRP) assay. Pharmacokinetic and physiochemical properties were optimized leading to compound (4S)-4-[({4-[4-(methoxymethyl)piperidin-1-yl]-6-phenylpyridin-2-yl} carbonyl)amino]-5-oxo-5-{4-[(pentyloxy) carbonyl]piperazin-1-yl}pentanoic acid 22J with good human PRP potency, selectivity, in vivo efficacy and oral bioavailability. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.06.075
• 作为产物：
  描述：

  2-acetoxybutanoyl chloride 、 二乙胺 生成 α-Hydroxy-buttersaeure-diethylamid
  参考文献：
  名称：

  α-Hydroxycarbonsäureamide

  摘要：

  DOI：

  10.1002/ardp.19602930214

文献信息

• Directed metalation/Snieckus rearrangement of O-benzylic carbamates
  作者：Pingsheng Zhang、Robert E. Gawley

  DOI：10.1021/jo00064a001

  日期：1993.6

  Benzylic carbamates undergo 1,2- or 1,4-carbamoyl migration reaction after lithiation with s-BuLi or LDA in THF.
• [EN] BIODEGRADABLE SOLVENT<br/>[FR] SOLVANT BIODÉGRADABLE
  申请人：BASF SE

  公开号：WO2018162554A1

  公开（公告）日：2018-09-13

  The present invention refers to a composition comprising a) from 1 to 60 wt.-%, based on the total weight of the composition, of at least one polymeric resin, and b) from 40 to 99 wt.-%, based on the total weight of the composition, of an organic solvent having a Hansen hydrogen bonding solubility parameter δΗ of greater than 11.0, and the use of an organic solvent having a Hansen hydrogen bonding solubility parameter δΗ of greater than 11.0 as biodegradable solvent as well as the use of the composition in the manufacturing process of enameled copper wires.