S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid methyl ester | 436864-61-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid methyl ester
• 英文别名: methyl 3-(4-amino-1-naphthyl)-N-(tert-butoxycarbonyl)-L-alaninate；methyl (2S)-3-(4-aminonaphthalen-1-yl)-2-[(2-methylpropan-2-yl)oxycarbonylamino]propanoate
• CAS: 436864-61-8
• 化学式: C₁₉H₂₄N₂O₄
• 分子量: 344.411
• InChiKey: BXCAZINWUDTILS-INIZCTEOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  25
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  90.6
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid methyl ester 在 N-甲基吗啉 、 sodium hydroxide 、 1-羟基苯并三唑 、 盐酸-N-乙基-Nˊ-(3-二甲氨基丙基)碳二亚胺 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 反应 21.67h， 生成 S-3-{[5-[(3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionyl)amino]pentyl]oxy}naphthalene-2-carboxylic acid methyl ester
  参考文献：
  名称：

  Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

  摘要：

  Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that downregulates the insulin receptor. Inhibition of PTP1B is expected to improve insulin action, and the design of small molecule PTP1B inhibitors to treat type II diabetes has received considerable attention. In this work, NMR-based screening identified a nonselective competitive inhibitor of PTP1B. A second site ligand was also identified by NMR-based screening and then linked to the catalytic site ligand by rational design. X-ray data confirmed that the inhibitor bound with the catalytic site in the native, "open" conformation. The final compound displayed excellent potency and good selectivity over many other phosphatases. The modular approach to drug design described in this work should be applicable for the design of potent and selective inhibitors of other therapeutically relevant protein tyrosine phosphatases.

  DOI：

  10.1021/ja0296733
• 作为产物：
  描述：

  4-溴-1-萘胺 、 (R)-N-叔丁氧羰基-3-碘代丙氨酸甲酯 在 锌 、 palladium diacetate 、 三(邻甲基苯基)磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 1.75h， 以46%的产率得到S-3-(4-aminonaphthalen-1-yl)-2-(tert-butoxycarbonylamino)propionic acid methyl ester
  参考文献：
  名称：

  Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy

  摘要：

  Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that downregulates the insulin receptor. Inhibition of PTP1B is expected to improve insulin action, and the design of small molecule PTP1B inhibitors to treat type II diabetes has received considerable attention. In this work, NMR-based screening identified a nonselective competitive inhibitor of PTP1B. A second site ligand was also identified by NMR-based screening and then linked to the catalytic site ligand by rational design. X-ray data confirmed that the inhibitor bound with the catalytic site in the native, "open" conformation. The final compound displayed excellent potency and good selectivity over many other phosphatases. The modular approach to drug design described in this work should be applicable for the design of potent and selective inhibitors of other therapeutically relevant protein tyrosine phosphatases.

  DOI：

  10.1021/ja0296733

文献信息

• Selective protein tyrosine phosphatatase inhibitors
  申请人：Liu Gang

  公开号：US06972340B2

  公开（公告）日：2005-12-06

  Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.

  化合物的分子式(I)或其治疗上可接受的盐是选择性蛋白酪氨酸激酶-B(PTP1B)抑制剂。该文披露了该类化合物的制备、含有该类化合物的组合物以及使用该类化合物治疗疾病的方法。
• [EN] SELECTIVE PROTEIN TYROSINE PHOSPHATASE INHIBITORS<br/>[FR] INHIBITEURS SELECTIFS DE PROTEINE TYROSINE PHOSPHATASE
  申请人：ABBOTT LAB

  公开号：WO2003020688A1

  公开（公告）日：2003-03-13

  Compounds of formula (I) or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.

  式(I)的化合物或其治疗上可接受的盐是选择性的蛋白酪氨酸激酶-B (PTP1B) 抑制剂。本文披露了该化合物的制备、含有该化合物的组合物以及使用该化合物治疗疾病的方法。
• US6972340B2
  申请人：——

  公开号：US6972340B2

  公开（公告）日：2005-12-06
• [EN] SELECTIVE PROTEIN TYROSINE PHOSPHATATASE INHIBITORS<br/>[FR] INHITIBTEURS SELECTIFS DE LA PROTEINE TYROSINE PHOSPHATATASE
  申请人：ABBOTT LAB

  公开号：WO2003072537A2

  公开（公告）日：2003-09-04

  Compounds of formula (I), or therapeutically acceptable salts thereof, are selective protein tyrosine kinase-B (PTP1B) inhibitors. Preparation of the compounds, compositions containing the compounds, and treatment of disorders using the compounds are disclosed.
• Discovery of a Potent, Selective Protein Tyrosine Phosphatase 1B Inhibitor Using a Linked-Fragment Strategy
  作者：Bruce G. Szczepankiewicz、Gang Liu、Philip J. Hajduk、Cele Abad-Zapatero、Zhonghua Pei、Zhili Xin、Thomas H. Lubben、James M. Trevillyan、Michael A. Stashko、Stephen J. Ballaron、Heng Liang、Flora Huang、Charles W. Hutchins、Stephen W. Fesik、Michael R. Jirousek

  DOI：10.1021/ja0296733

  日期：2003.4.1

  Protein tyrosine phosphatase 1B (PTP1B) is an enzyme that downregulates the insulin receptor. Inhibition of PTP1B is expected to improve insulin action, and the design of small molecule PTP1B inhibitors to treat type II diabetes has received considerable attention. In this work, NMR-based screening identified a nonselective competitive inhibitor of PTP1B. A second site ligand was also identified by NMR-based screening and then linked to the catalytic site ligand by rational design. X-ray data confirmed that the inhibitor bound with the catalytic site in the native, "open" conformation. The final compound displayed excellent potency and good selectivity over many other phosphatases. The modular approach to drug design described in this work should be applicable for the design of potent and selective inhibitors of other therapeutically relevant protein tyrosine phosphatases.