(R)-2-Amino-N-phenethyl-2-phenyl-acetamide | 339208-96-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (R)-2-Amino-N-phenethyl-2-phenyl-acetamide
• 英文别名: (2R)-2-amino-2-phenyl-N-(2-phenylethyl)acetamide
• CAS: 339208-96-7
• 化学式: C₁₆H₁₈N₂O
• 分子量: 254.332
• InChiKey: MOXCHWYAFKKILQ-OAHLLOKOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.19
• 拓扑面积：
  55.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  (R)-2-Amino-N-phenethyl-2-phenyl-acetamide 、 3-amidino-benzoic acid TFA salt 在 1-羟基苯并三唑 、 N,N'-二异丙基碳二亚胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.17h， 生成 3-Carbamimidoyl-N-((R)-phenethylcarbamoyl-phenyl-methyl)-benzamide
  参考文献：
  名称：

  The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa

  摘要：

  Factor Xa, a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel anti-thrombotic agents. Here we describe the development of phenylglycine containing benzamidine carboxamides as novel, potent and selective inhibitors of factor Xa. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00042-7
• 作为产物：
  描述：

  Boc-D-苯甘氨酸 在 N-羟基-7-氮杂苯并三氮唑 、 1-(3-二甲基氨基丙基)-3-乙基碳二亚胺 、 三氟乙酸 作用下， 以 二氯甲烷 、 N,N-二甲基甲酰胺 为溶剂， 反应 2.17h， 生成 (R)-2-Amino-N-phenethyl-2-phenyl-acetamide
  参考文献：
  名称：

  The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa

  摘要：

  Factor Xa, a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel anti-thrombotic agents. Here we describe the development of phenylglycine containing benzamidine carboxamides as novel, potent and selective inhibitors of factor Xa. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00042-7

文献信息

• The design of phenylglycine containing benzamidine carboxamides as potent and selective inhibitors of factor Xa
  作者：Stuart D Jones、John W Liebeschuetz、Phillip J Morgan、Christopher W Murray、Andrew D Rimmer、Jonathan M.E Roscoe、Bohdan Waszkowycz、Pauline M Welsh、William A Wylie、Stephen C Young、Harry Martin、Jacqui Mahler、Leo Brady、Kay Wilkinson

  DOI：10.1016/s0960-894x(01)00042-7

  日期：2001.3

  Factor Xa, a critical serine protease in the blood coagulation cascade, has become a target for inhibition as a strategy for the invention of novel anti-thrombotic agents. Here we describe the development of phenylglycine containing benzamidine carboxamides as novel, potent and selective inhibitors of factor Xa. (C) 2001 Elsevier Science Ltd. All rights reserved.