5-formyl-1,3-dimethyl-6-(2-dimethylamino-vinyl)uracil | 116705-37-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-formyl-1,3-dimethyl-6-(2-dimethylamino-vinyl)uracil
• 英文别名: 4-[(E)-2-(dimethylamino)ethenyl]-1,3-dimethyl-2,6-dioxopyrimidine-5-carbaldehyde
• CAS: 116705-37-4
• 化学式: C₁₁H₁₅N₃O₃
• 分子量: 237.258
• InChiKey: QTEVBEHSGMOJGM-AATRIKPKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  60.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-formyl-1,3-dimethyl-6-(2-dimethylamino-vinyl)uracil 在 2,4,6-三甲基苯磺酰肼 、 potassium carbonate 、 溶剂黄146 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 6.5h， 生成 1,3-dimethylpyrido[4,3-d]pyrimidine-2,4(1H,3H)-dione 6-imide
  参考文献：
  名称：

  Convenient Synthesis of Pyrido[4,3-d]-pyrimidine-2,4(1H,3H)-diones

  摘要：

  A convenient synthesis of pyrido[4, 3-d]pyrimidine-2,4(1H, 3H)-diones is described. Treatment of 5-formyl-1,3-dimethyl-6-(2-dimethylamino)-vinyluracil(1) with ammonia and hydrazines affords the corresponding pyrido[4,3-d]pyrimidine-2,4(1H, 3H)-diones (2 and 3), respectively. Similar reaction of 5-cyano- and 5-ethoxycarbonyluracils (10 and 15) with ammonia led to formation of 5-amino- and 5-hydroxylpyrido[4;3-d]pyrimidine-2,4(1H 3H)-diones (11 and 16), respectively.

  DOI：

  10.3987/com-97-s(n)97
• 作为产物：
  描述：

  N,N-二甲基甲酰胺二甲基缩醛 、 1,3,6-三甲基-2,4-二氧代-1,2,3,4-四氢嘧啶-5-甲醛 以 N,N-二甲基甲酰胺 为溶剂， 以82%的产率得到5-formyl-1,3-dimethyl-6-(2-dimethylamino-vinyl)uracil
  参考文献：
  名称：

  Hirota, Kosaku; Abe, Yoshio; Asao, Tetsuji, Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 985 - 990

  摘要：

  DOI：

文献信息

• Substituted 1,3-dialkylpyrido[4,3-d]pyrimidine-2,4-diones
  申请人：Nippon Zoki Pharmaceutical Co., Ltd.

  公开号：US04808618A1

  公开（公告）日：1989-02-28

  The present invention relates to a novel pyrido[4,3-d]pyrimidine derivative having the formula (I): ##STR1## wherein each of R.sub.1 and R.sub.2, which may be the same or different, is a lower alkyl group; R.sub.3 is hydrogen, halogen, hydroxy, amino, hydroxyamino, imino, hydrazino or a lower alkylamino group which may optionally have hydroxy, amino or a lower alkylamino group; and R.sub.4 is hydrogen, amino, --NH.sup..crclbar. or a lower alkyl group which may optionally have hydroxy, amino or a lower alkylamino group; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, for the treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.

  本发明涉及一种具有以下式子(I)的新型吡啶并[4,3-d]嘧啶衍生物：##STR1## 其中，R.sub.1和R.sub.2分别相同或不同，是低碳基团；R.sub.3是氢、卤素、羟基、氨基、羟氨基、亚氨基、叠氮基或可选择具有羟基、氨基或低碳基团的低碳基团；R.sub.4是氢、氨基、--NH.sup..crclbar.或可选择具有羟基、氨基或低碳基团的低碳基团；以及其药学上可接受的盐。这些化合物可用作抗过敏剂，例如用于治疗支气管哮喘、荨麻疹、过敏性鼻炎、过敏性皮肤病或过敏性结膜炎。
• Pyrido[4,3-d]pyrimidine derivatives
  申请人：NIPPON ZOKI PHARMACEUTICAL CO. LTD.

  公开号：EP0244352A2

  公开（公告）日：1987-11-04

  The present invention relates to pyrido[4,3-d]pyrimidine derivatives having the formula (I): wherein each of R, and R2, which may be the same or different, is a lower alkyl group; R3 is hydrogen, halogen, hydroxy, amino, hydroxyamino, imino, hydrazino or a lower alkylamino group which may optionally be substituted by hydroxy, amino or a lower alkylamino group; and R4 is hydrogen, amino, -NHe or a lower alkyl group which may optionally be substituted by hydroxy, amino or a lower alkylamino group; and pharmaceutically acceptable salt thereof. These compounds are useful as anti-allergic agents, for example, forthe treatment of bronchial asthma, urticaria, allergic rhinitis, allergic dermatoses or allergic conjunctivitis.

  本发明涉及具有式(I)的吡啶并[4,3-d]嘧啶衍生物： 其中 R 和 R2（可以相同或不同）均为低级烷基；R3 为氢、卤素、羟基、氨基、羟基氨基、亚氨基、肼基或可任选被羟基、氨基或低级烷基氨基取代的低级烷基氨基；R4 为氢、氨基、-NHe 或可任选被羟基、氨基或低级烷基氨基取代的低级烷基；及其药学上可接受的盐。这些化合物可用作抗过敏剂，例如用于治疗支气管哮喘、荨麻疹、过敏性鼻炎、过敏性皮肤病或过敏性结膜炎。
• GO, KOITIRO;KURIMOTO, IOSIYUKI;KITAMURA, NORIXIKO
  作者：GO, KOITIRO、KURIMOTO, IOSIYUKI、KITAMURA, NORIXIKO

  DOI：——

  日期：——
• GO, KOUICHIRO;KURIMOTO, YOSHIYUKI;KITAMURA, NORIHIKO
  作者：GO, KOUICHIRO、KURIMOTO, YOSHIYUKI、KITAMURA, NORIHIKO

  DOI：——

  日期：——
• HIROTA, KOSAKU;ABE, YOSHIO;ASAO, TETSUJI;SENDA, SHIGEO;KITADE, YUKIO;MAKI+, J. HETEROCYCL. CHEM., 25,(1988) N 3, C. 985-990
  作者：HIROTA, KOSAKU、ABE, YOSHIO、ASAO, TETSUJI、SENDA, SHIGEO、KITADE, YUKIO、MAKI+

  DOI：——

  日期：——