4-Aminophenyl 2-hydroxypropyl ether | 212835-42-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 4-Aminophenyl 2-hydroxypropyl ether
• 英文别名: 1-(4-aminophenoxy)propan-2-ol
• CAS: 212835-42-2
• 化学式: C₉H₁₃NO₂
• 分子量: 167.208
• InChiKey: HVNOWXUNCGUHEP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  55.5
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-Aminophenyl 2-hydroxypropyl ether 在 三乙胺 作用下， 以 乙醚 、 二氯甲烷 为溶剂， 反应 123.0h， 生成 Toluene-4-sulfonate{2-[4-(2-hydroxy-propoxy)-phenylcarbamoyl]-ethyl}-dimethyl-sulfonium;
  参考文献：
  名称：

  Synthesis and Antiallergic Activity of Dimethyl-2-(phenylcarbamoyl)ethylsulfonium p-Toluenesulfonate Derivatives

  摘要：

  The derivatives of dimethyl-2-(phenylcarbamoyl)ethylsulfonium p-toluenesulfonates were synthesized and evaluated for antiallergic activity. The 2,3-dihydroxyethoxy group was introduced to the phenyl ring from the standpoint of lipophilicity and electronic effects of substituent. The IgE-induced rat passive cutaneous anaphylaxis (PCA) was inhibited by oral administration of several substituted 2-[(4-propoxyphenyl)carbamoyl]ethyldimethylsulfonium p-toluenesulfonate derivatives. Among them (+/-)-2-[4-(3-ethoxy-2-hydroxypropoxy)phenyl]-carbamoyl]ethyldimethylsulfonium p-toluenesulfonate (1a, IPD-1151T) was found to possess considerable activity in the PCA test, and it was launched as Suplatast tosilate in Japan.

  DOI：

  10.1021/jm970285z
• 作为产物：
  描述：

  2-[(4-硝基苯氧基)甲基]环氧乙烷 在 5percent Pd/C(en) 氢气 作用下， 以 四氢呋喃 为溶剂， 反应 3.0h， 生成 4-Aminophenyl 2-hydroxypropyl ether 、 7-氯-2-甲基咪唑并[1,2-a]吡啶
  参考文献：
  名称：

  Highly Chemoselective Hydrogenation with Retention of the Epoxide Function Using a Heterogeneous Pd/C-Ethylenediamine Catalyst and THF

  摘要：

  In general, palladium-carbon (Pd/C) catalyzed hydrogenation of epoxides affords the corresponding primary and secondary alcohols as a mixture. It has been found that the catalytic activity of a Pd/C -ethylenediamine complex catalyst [Pd/C(en)] in the hydrogenolysis of epoxide functions is drastically reduced. Herein we describe a mild and chemoselective method for the hydrogenation of olefin, nitro, and azide functions with retention of the epoxide function. The chemoselectivity was accomplished by using a combination of 5% Pd/C(en) and THF as solvent. A significant drop in the chemoselectivity of the hydrogenation is observed with 5% Pd/C(en) in MeOH. These results reinforce the utility of epoxides as important precursors of alcohols in synthetic chemistry.

  DOI：

  10.1002/1521-3765(20000616)6:12<2200::aid-chem2200>3.0.co;2-3

文献信息

• Diamine and acid anhydride
  申请人：Kanegafuchi Kagaku Kogyo Kabushiki Kaisha

  公开号：US20020019558A1

  公开（公告）日：2002-02-14

  The present invention provides a novel diamine and a novel acid anhydride which are applicable for a polyimide and includes a cinnamoyl group or a derived cinnamoyl group. The novel diamines and acid anhydrides have photo-reactivity and heat-reactivity inherent to the cinnamoyl group.

  本发明提供了一种新型二胺和一种新型酸酐，适用于聚酰亚胺，并包括一个肉桂酰基或衍生的肉桂酰基。这些新型二胺和酸酐具有与肉桂酰基固有的光反应性和热反应性。
• US3956267A
  申请人：——

  公开号：US3956267A

  公开（公告）日：1976-05-11
• US4036824A
  申请人：——

  公开号：US4036824A

  公开（公告）日：1977-07-19
• US6689899B2
  申请人：——

  公开号：US6689899B2

  公开（公告）日：2004-02-10