N-(2-benzoyl-4-chlorophenyl)-2-morpholin-4-ylacetamide | 59542-15-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-benzoyl-4-chlorophenyl)-2-morpholin-4-ylacetamide
• 英文别名: N-(2-Benzoyl-4-chlorophenyl)-4-morpholineacetamide
• CAS: 59542-15-3
• 化学式: C₁₉H₁₉ClN₂O₃
• mdl: MFCD00831736
• 分子量: 358.824
• InChiKey: NIAZLCPHEGUPGY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  25
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  58.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  N-(2-benzoyl-4-chlorophenyl)-2-morpholin-4-ylacetamide 在 potassium tert-butylate 作用下， 以 二甲基亚砜 为溶剂， 反应 0.5h， 以60%的产率得到6-chloro-3-morpholin-4-yl-4-phenyl-2(1H)-quinolone
  参考文献：
  名称：

  3-Amino-2(1H)-quinolones by Cyclizaion of N-Acylated Anthranilic Acid Derivatives

  摘要：

  Reaction of secondary amines with the N-(iodoacetyl)anthranilic acid derivatives, 2-(iodoacetylamino)acetophenone and 2-(iodoacetylamino)benzophenone yields 3-amino-2(1H)-quinolones in two steps. Analogously heterocondensed 5-amino-6(7H)-pyrazolo[5,4-b]pyridones were prepared. Hydroxyquinolines were subjected to Cl/OH exchange to give chloroquinolines, which are convenient for consecutive reactions.

  DOI：

  10.3987/com-96-7700
• 作为产物：
  描述：

  2-氨基-5-氯二苯甲酮 在 potassium carbonate 、 potassium iodide 作用下， 以 1,4-二氧六环 、 乙醇 、 丙酮 为溶剂， 反应 1.0h， 生成 N-(2-benzoyl-4-chlorophenyl)-2-morpholin-4-ylacetamide
  参考文献：
  名称：

  3-Amino-2(1H)-quinolones by Cyclizaion of N-Acylated Anthranilic Acid Derivatives

  摘要：

  Reaction of secondary amines with the N-(iodoacetyl)anthranilic acid derivatives, 2-(iodoacetylamino)acetophenone and 2-(iodoacetylamino)benzophenone yields 3-amino-2(1H)-quinolones in two steps. Analogously heterocondensed 5-amino-6(7H)-pyrazolo[5,4-b]pyridones were prepared. Hydroxyquinolines were subjected to Cl/OH exchange to give chloroquinolines, which are convenient for consecutive reactions.

  DOI：

  10.3987/com-96-7700

文献信息

• Nouveaux dérivés de benzoyl-2-chloro-4-glycinanilides substitués, leur procédé de préparation et leur application en tant que médicaments.
  申请人：PIERRE FABRE S.A.

  公开号：EP0000299B1

  公开（公告）日：1980-11-12
• 3-Amino-2(1H)-quinolones by Cyclizaion of N-Acylated Anthranilic Acid Derivatives
  作者：Matthias Rehwald、Karl Gewald、Hans-Joachim Lankau、Klaus Unverferth

  DOI：10.3987/com-96-7700

  日期：——

  Reaction of secondary amines with the N-(iodoacetyl)anthranilic acid derivatives, 2-(iodoacetylamino)acetophenone and 2-(iodoacetylamino)benzophenone yields 3-amino-2(1H)-quinolones in two steps. Analogously heterocondensed 5-amino-6(7H)-pyrazolo[5,4-b]pyridones were prepared. Hydroxyquinolines were subjected to Cl/OH exchange to give chloroquinolines, which are convenient for consecutive reactions.