4-hydroxy-1-morpholino-4-phenylbutan-1-one | 101115-22-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-hydroxy-1-morpholino-4-phenylbutan-1-one
• 英文别名: 4-(4-hydroxy-4-phenyl-butyryl)-morpholine；4-(4-Hydroxy-4-phenyl-butyryl)-morpholin；4-Hydroxy-1-morpholin-4-yl-4-phenylbutan-1-one；4-hydroxy-1-morpholin-4-yl-4-phenylbutan-1-one
• CAS: 101115-22-4
• 化学式: C₁₄H₁₉NO₃
• 分子量: 249.31
• InChiKey: FDBLMNHVPJYPKY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-吗啉-4-基-4-苯基丁烷-1,4-二酮 在 C₅₀H₅₂Cl₂O₄P₂Ru*C₁₉H₂₆N₂O₂ 、 potassium tert-butylate 、 氢气 作用下， 以 异丙醇 为溶剂， 30.0 ℃ 、1.01 MPa 条件下， 反应 15.0h， 以97%的产率得到4-hydroxy-1-morpholino-4-phenylbutan-1-one
  参考文献：
  名称：

  Enantioselective Ruthenium(II)/Xyl-SunPhos/Daipen-Catalyzed Hydrogenation of γ-Ketoamides

  摘要：

  A series of gamma-hydroxy amides were synthesized with high enantioselectivities (up to 99%) using asymmetric hydrogenation of the corresponding gamma-ketoamides in the presence of Ru-Xyl-SunPhos-Daipen catalyst providing key building blocks for a variety of naturally occurring and biologically active compounds.

  DOI：

  10.1021/jo5008916

文献信息

• Studies with the Amine Adducts of β-Benzoylacrylic Acid and its Methyl Ester¹
  作者：Norman H. Cromwell、Paul L. Creger、Kenneth E. Cook

  DOI：10.1021/ja01598a058

  日期：1956.9
• Enantioselective Ruthenium(II)/Xyl-SunPhos/Daipen-Catalyzed Hydrogenation of γ-Ketoamides
  作者：Mengmeng Zhao、Wanfang Li、Xiaoming Li、Kai Ren、Xiaoming Tao、Xiaomin Xie、Tahar Ayad、Virginie Ratovelomanana-Vidal、Zhaoguo Zhang

  DOI：10.1021/jo5008916

  日期：2014.7.3

  A series of gamma-hydroxy amides were synthesized with high enantioselectivities (up to 99%) using asymmetric hydrogenation of the corresponding gamma-ketoamides in the presence of Ru-Xyl-SunPhos-Daipen catalyst providing key building blocks for a variety of naturally occurring and biologically active compounds.