6-(((tert-butyl(dimethyl)silyl)oxy)methyl)-N-thiazol-2-ylpyridin-2-amine | 885325-72-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 6-(((tert-butyl(dimethyl)silyl)oxy)methyl)-N-thiazol-2-ylpyridin-2-amine
• 英文别名: N-[6-[[tert-butyl(dimethyl)silyl]oxymethyl]pyridin-2-yl]-1,3-thiazol-2-amine
• CAS: 885325-72-4
• 化学式: C₁₅H₂₃N₃OSSi
• 分子量: 321.519
• InChiKey: WYEBMCIZKGPWPH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  21
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  75.3
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  6-(((tert-butyl(dimethyl)silyl)oxy)methyl)-N-thiazol-2-ylpyridin-2-amine 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 反应 1.0h， 生成 (6-(thiazol-2-ylamino)pyridin-2-yl)methanol
  参考文献：
  名称：

  WO2006/46735

  摘要：

  公开号：
• 作为产物：
  描述：

  6-溴吡啶-2-甲醇 在 咪唑 、 tris-(dibenzylideneacetone)dipalladium(0) 、 caesium carbonate 、 4,5-双二苯基膦-9,9-二甲基氧杂蒽 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 17.5h， 生成 6-(((tert-butyl(dimethyl)silyl)oxy)methyl)-N-thiazol-2-ylpyridin-2-amine
  参考文献：
  名称：

  Targeted AURKA degradation: Towards new therapeutic agents for neuroblastoma

  摘要：

  DOI：

  10.1016/j.ejmech.2022.115033

文献信息

• Novel aminopyridine derivatives having aurora a selective inhibitory action
  申请人：Iwasawa Yoshikuzu

  公开号：US20080058347A1

  公开（公告）日：2008-03-06

  The present invention relates to a compound of formula I: wherein: R 1 is a hydrogen atom, F, CN, etc.; R 1 ′ is a hydrogen atom or lower alkyl which may be substituted; R 2 is O, S, SO, SO 2 , etc.; R 3 is a phenyl which may be substituted; X 1 , X 2 , and X 3 each independently CH, N, etc. provided, however, that among X 1 , X 2 and X 3 , the number of nitrogen is 0 or 1; W is the following residue: wherein: W 1 , W 2 , and W 3 each independently CH, N, etc., or a pharmaceutically acceptable salt or ester thereof.

  本发明涉及一种化合物，其化学式为I：其中：R1为氢原子，F，CN等；R1′为氢原子或可被取代的较低烷基；R2为O，S，SO，SO2等；R3为可被取代的苯基；X1，X2和X3各自独立为CH，N等，但在X1，X2和X3中，氮的数量为0或1；W为以下残基：其中：W1，W2和W3各自独立为CH，N等，或其药用可接受的盐或酯。
• Novel Aminopyridine Derivatives Having Aurora a Selective Inhibitory Action
  申请人：Ohkubo Mitsuru

  公开号：US20080027042A1

  公开（公告）日：2008-01-31

  The present invention relates to a compound represented by the general formula (I): wherein m 1 and m 2 are 1, 2, or 3; n 1 and n 2 are 0 or 1; i is an integer of any of 1 to m 1 ; j is an integer of 1 to m 2 ; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; R ai and R ai ′ is hydrogen atom, etc. and R bj and R bj ′ is hydrogen atom, etc.; R c , R d , and R e are hydrogen atom, etc; X 1 is CH, CX 1a , or N; X 2 is CH, N, etc.; X 3 is CH, N, etc.; X 4 is CH or N; Y 1 , Y 2 , and Y 3 are each independently CH or N; Z 1 and Z 2 are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).

  本发明涉及一种由通式（I）表示的化合物：其中m1和m2为1、2或3；n1和n2为0或1；i为1到m1的任意整数；j为1到m2的任意整数；R为芳基、杂环芳基或环烷基，其中任何一个都可以被取代；Rai和Rai′为氢原子等；Rbj和Rbj′为氢原子等；Rc、Rd和Re为氢原子等；X1为CH、CX1a或N；X2为CH、N等；X3为CH、N等；X4为CH或N；Y1、Y2和Y3分别独立为CH或N；Z1和Z2分别独立为CH或N；W为5-成员芳香杂环基，例如吡唑基、噻唑基等，或其药学上可接受的盐或酯；以及含有该化合物的药物组合物或抗肿瘤剂；以及与其他抗肿瘤剂的组合使用。
• Aminopyridine derivatives having Aurora A selective inhibitory action
  申请人：Banyu Pharmaceutical Co., Ltd.

  公开号：US07491720B2

  公开（公告）日：2009-02-17

  The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1; j is an integer of 1 to m2; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rai and Rai′ is hydrogen atom, etc. and Rbj and Rbj′ is hydrogen atom, etc.; Rc, Rd, and Re are hydrogen atom, etc; X1 is CH, CX1a, or N; X2 is CH, N, etc.; X3 is CH, N, etc.; X4 is CH or N; Y1, Y2, and Y3 are each independently CH or N; Z1 and Z2 are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).

  本发明涉及一种由通式(I)表示的化合物：其中m1和m2为1、2或3；n1和n2为0或1；i为1到m1的任意整数；j为1到m2的任意整数；R为芳基、杂环芳基或环烷基，其中任何一种可能被取代；Rai和Rai′为氢原子等；Rbj和Rbj′为氢原子等；Rc、Rd和Re为氢原子等；X1为CH、CX1a或N；X2为CH、N等；X3为CH、N等；X4为CH或N；Y1、Y2和Y3各自独立地为CH或N；Z1和Z2各自独立地为CH或N；W为5-成员芳香杂环基，例如吡唑基、噻唑基等，或其药学上可接受的盐或酯；包含该化合物的制药组合物或抗肿瘤剂；以及该抗肿瘤剂与其他抗肿瘤剂的组合。
• Aminopyridine derivatives having aurora a selective inhibitory action
  申请人：Banyu Pharmaceutical Co., Ltd

  公开号：US07834018B2

  公开（公告）日：2010-11-16

  The present invention relates to a compound represented by the general formula (I): wherein m1 and m2 are 1, 2, or 3; n1 and n2 are 0 or 1; i is an integer of any of 1 to m1; j is an integer of 1 to m2; R is aryl, heteroaryl, or cycloalkyl any of which may be substituted; Rai and Rai′ is hydrogen atom, etc. and Rbj and Rbj′ is hydrogen atom, etc.; Rc, Rd, and Re are hydrogen atom, etc; X1 is CH, CX1a, or N; X2 is CH, N, etc.; X3 is CH, N, etc.; X4 is CH or N; Y1, Y2, and Y3 are each independently CH or N; Z1 and Z2 are each independently CH or N; W is a 5-membered aromatic heterocyclic group such as pyrazolyl, thiazolyl, etc., or a pharmaceutically acceptable salt or ester thereof; a pharmaceutical composition or antitumor agent containing the same; and combinations of the antitumor agent with other antitumor agent(s).

  本发明涉及一种由通式（I）表示的化合物：其中m1和m2为1、2或3；n1和n2为0或1；i为1至m1的任意整数；j为1至m2的任意整数；R为芳基、杂芳基或环烷基，其中任何一个可以被取代；Rai和Rai′为氢原子等；Rbj和Rbj′为氢原子等；Rc、Rd和Re为氢原子等；X1为CH、CX1a或N；X2为CH、N等；X3为CH、N等；X4为CH或N；Y1、Y2和Y3各自独立地为CH或N；Z1和Z2各自独立地为CH或N；W为5-成员芳香杂环基，例如吡唑基、噻唑基等，或其药学上可接受的盐或酯；包含该化合物的药物组合物或抗肿瘤剂；以及该抗肿瘤剂与其他抗肿瘤剂的组合。
• WO2006/46735
  申请人：——

  公开号：——

  公开（公告）日：——