摩熵化学
数据库官网
小程序
打开微信扫一扫
首页 分子通 化学资讯 化学百科 反应查询 关于我们
请输入关键词

5,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid | 50635-27-3

中文名称
——
中文别名
——
英文名称
5,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid
英文别名
5,7-Dichloro-2,3-dihydro-1-benzofuran-2-carboxylic acid;5,7-dichloro-2,3-dihydro-1-benzofuran-2-carboxylic acid
5,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid化学式
CAS
50635-27-3
化学式
C9H6Cl2O3
mdl
——
分子量
233.051
InChiKey
LYTAJWLMNJOOKB-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    2.8
  • 重原子数:
    14
  • 可旋转键数:
    1
  • 环数:
    2.0
  • sp3杂化的碳原子比例:
    0.22
  • 拓扑面积:
    46.5
  • 氢给体数:
    1
  • 氢受体数:
    3

上下游信息

  • 上游原料
    中文名称 英文名称 CAS号 化学式 分子量
  • 下游产品
    中文名称 英文名称 CAS号 化学式 分子量

反应信息

  • 作为反应物:
    描述:
    参考文献:
    名称:
    .alpha.-Adrenoceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on .alpha.-adrenoreceptor activity
    摘要:
    Modification of the 1,4-benzodioxan ring present in RX 781094 has not previously been considered. This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene group and also those in which the ring size has been changed to give, for example, furan and thiophene derivatives. The dihydrobenzofuranylimidazoline compound 7 is the only analogue possessing presynaptic antagonist potency potency and selectivity comparable to that of 1. In view of this result, a number of derivatives was prepared to determine the structure-activity relationships within this series. Many derivatives, as well as the parent compound 7, were found to possess presynaptic alpha 2-adrenoreceptor antagonist and postsynaptic alpha 1-adrenoreceptor partial agonist properties. Two of the selective presynaptic antagonists, 13 and 14 possess greater potency and selectivity than that possessed by 1. The 5-chloro derivative 25 is twice as potent as after oral administration but only about half as potent when given intravenously.
    DOI:
    10.1021/jm00371a003
  • 作为产物:
    描述:
    2-Allyl-4,6-dichlor-phenol 在 jones' reagent 、 Kieselgel 60 、 间氯过氧苯甲酸 作用下, 以 二氯甲烷丙酮 为溶剂, 反应 96.0h, 生成 5,7-dichloro-2,3-dihydrobenzofuran-2-carboxylic acid
    参考文献:
    名称:
    .alpha.-Adrenoceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on .alpha.-adrenoreceptor activity
    摘要:
    Modification of the 1,4-benzodioxan ring present in RX 781094 has not previously been considered. This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene group and also those in which the ring size has been changed to give, for example, furan and thiophene derivatives. The dihydrobenzofuranylimidazoline compound 7 is the only analogue possessing presynaptic antagonist potency potency and selectivity comparable to that of 1. In view of this result, a number of derivatives was prepared to determine the structure-activity relationships within this series. Many derivatives, as well as the parent compound 7, were found to possess presynaptic alpha 2-adrenoreceptor antagonist and postsynaptic alpha 1-adrenoreceptor partial agonist properties. Two of the selective presynaptic antagonists, 13 and 14 possess greater potency and selectivity than that possessed by 1. The 5-chloro derivative 25 is twice as potent as after oral administration but only about half as potent when given intravenously.
    DOI:
    10.1021/jm00371a003
点击查看最新优质反应信息

文献信息

  • Novel Herbicide Resistance Genes
    申请人:Lira Justin M.
    公开号:US20100251432A1
    公开(公告)日:2010-09-30
    The subject invention provides novel plants that are not only resistant to 2,4-D, but also to a pyridyloxyacetate herbicide. The subject invention also includes plants that produce one or more enzymes of the subject invention “stacked” together with one or more other herbicide resistance genes. The subject invention enables novel combinations of herbicides to be used in new ways. Furthermore, the subject invention provides novel methods of preventing the development of, and controlling, strains of weeds that are resistant to one or more herbicides such as glyphosate. The preferred enzyme and gene for use according to the subject invention are referred to herein as AAD-13 (AryloxyAlkanoate Dioxygenase). This highly novel discovery is the basis of significant herbicide tolerant crop trait and selectable marker opportunities.
    该发明提供了一种新型植物,不仅对2,4-D具有抗性,而且对吡啶氧基乙酸类除草剂也具有抗性。该发明还包括将该发明的一种或多种酶与一种或多种其他除草剂抗性基因“堆叠”在一起的植物。该发明使得新型除草剂的组合可以以新的方式使用。此外,该发明提供了一种防止发展和控制对一种或多种除草剂(如草甘膦)具有抗性的杂草品系的新方法。该发明中用于使用的首选酶和基因被称为AAD-13(芳氧基烷酸双加氧酶)。这一高度新颖的发现是重要的除草剂耐受性作物性状和可选择标记机会的基础。
  • US8278505B2
    申请人:——
    公开号:US8278505B2
    公开(公告)日:2012-10-02
  • .alpha.-Adrenoceptor reagents. 2. Effects of modification of the 1,4-benzodioxan ring system on .alpha.-adrenoreceptor activity
    作者:Christopher B. Chapleo、Peter L. Myers、Richard C. M. Butler、John A. Davis、John C. Doxey、Stanley D. Higgins、Malcolm Myers、Alan G. Roach、Colin F. C. Smith
    DOI:10.1021/jm00371a003
    日期:1984.5
    Modification of the 1,4-benzodioxan ring present in RX 781094 has not previously been considered. This paper describes a number of analogues of this ring system, including compounds in which one of the oxygen atoms has been replaced by a methylene group and also those in which the ring size has been changed to give, for example, furan and thiophene derivatives. The dihydrobenzofuranylimidazoline compound 7 is the only analogue possessing presynaptic antagonist potency potency and selectivity comparable to that of 1. In view of this result, a number of derivatives was prepared to determine the structure-activity relationships within this series. Many derivatives, as well as the parent compound 7, were found to possess presynaptic alpha 2-adrenoreceptor antagonist and postsynaptic alpha 1-adrenoreceptor partial agonist properties. Two of the selective presynaptic antagonists, 13 and 14 possess greater potency and selectivity than that possessed by 1. The 5-chloro derivative 25 is twice as potent as after oral administration but only about half as potent when given intravenously.
查看更多

同类化合物

黄曲霉毒素 D1 顺式-3alpha,8alpha-二氢-4,6-二甲氧基-呋喃并[2,3-b]苯并呋喃 阿莫拉酮 苯甲醇,-α--甲基-4-(2-甲基丙基)-,乙酸酯(9CI) 苯并呋喃,7-氯-2,3-二氢-2,2-二甲基- 苯并呋喃,4-氯-2,3-二氢- 苯并呋喃,2,3-二氢-3-[(苯基硫代)甲基]- 苯并二氢呋喃-4-甲醛 苯并二氢呋喃-4-甲酸 苯并二氢呋喃-2-羧酸 胆甾-8-烯-3,15-二醇,(3b,5a,15a)-(9CI) 盐酸依法洛沙 甲基氨基甲酸4-氯-2,3-二氢-2,2-二甲基苯并呋喃-7-基酯 甲基5-氨基-2,3-二氢-1-苯并呋喃-2-羧酸酯 甲基2-乙基-6-羟基-2,3-二氢-1-苯并呋喃-2-羧酸酯 甲基(2S)-2-乙基-2,3-二氢-1-苯并呋喃-2-羧酸酯 环丙基甲胺 灭草呋喃 氘代克百威(呋喃丹) 普芦卡必利杂质H 抗氧剂136 多特林中间体 呋草黄 呋罗芬酸 呋喃酚 十一碳烯 克百威 依法克生 他司美琼 人参宁 二苯基异壬基膦酸酯 二硫代双(甲基氨基甲酸)双(2,3-二氢-2,2-二甲基-7-苯并呋喃)酯 二[2,3-二氢-2,2-二甲基-7-苯并呋喃重氮鎓]硫酸盐 二-2,3-二氢-1-苯并呋喃-5-基乙酸 乙基3-(7-溴-2,3-二氢-1-苯并呋喃-5-基)丙酸酯 丙硫克百威 丁硫克百威 [2H4]-2,3-二氢-5-苯并呋喃乙醇 [2H18]-丁硫克百威 [2-[2-氧代-5-(2,4,4-三甲基戊烷-2-基)-3H-1-苯并呋喃-3-基]-4-(2,4,4-三甲基戊烷-2-基)苯基]乙酸酯 [2,3-二氢-1-苯并呋喃-3-基(苯基)甲基]-二甲基-苯基硅烷 [2,2-二甲基-7-(甲基氨基甲酰氧基)-3H-1-苯并呋喃-3-基](Z)-2-甲基丁-2-烯酸酯 N-甲基氨基甲酸2,3-二氢苯并呋喃-7-基酯 N-甲基氨基甲酸2,3-二氢-2,2,4-三甲基苯并呋喃-7-基酯 N-甲基-[(2,3-二氢苯并[b]呋喃-7-基)甲基]胺 N-甲基(2,3-二氢苯并呋喃-2-基)甲胺盐酸盐 N-亚硝基羰基呋喃 N-[[(2S)-1-乙基吡咯烷-2-基]甲基]-5-碘-2,3-二氢-1-苯并呋喃-7-甲酰胺 N-[(2,2-二甲基-2,3-二氢-1-苯并呋喃-7-基)甲基]-n-甲胺 N-(吗啉基硫基)呋喃丹