二-2-吡嗪基甲酮 | 1021298-90-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 中文名称: 二-2-吡嗪基甲酮
• 英文名称: di-2-pyrazinylmethanone
• 英文别名: di-2-pyrazinyl ketone；Pyrazyl ketone；di(pyrazin-2-yl)methanone
• CAS: 1021298-90-7
• 化学式: C₉H₆N₄O
• 分子量: 186.173
• InChiKey: GWBKBANICXIZDE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.3
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  68.6
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  二-2-吡嗪基甲酮 在 一水合肼 、 potassium hydroxide 作用下， 以 乙二醇 为溶剂， 以53%的产率得到2,2'-dipyrazinylmethane
  参考文献：
  名称：

  Fused pyrazino[2,3-b]indolizine and indolizino[2,3-b]quinoxaline derivatives; synthesis, structures, and properties

  摘要：

  The synthesis of six new compounds incorporating either a pyrazino[2,3-b]indolizine or indolizino[2,3-b] quinoxaline core are reported in good yield (58-87%). The intermediates for the key cyclization reaction for one set of compounds (5a-c), with a sterically demanding 3,5-dimethylpyrazole group in the 5-position of the core, were found to be mono-substituted. These intermediates could be isolated and cyclized by heating under acid-catalyzed conditions. To further demonstrate the versatility of the chemistry, compounds 6a-c were synthesized in 58-68% yields. Compounds 5a-c are non-planar in solution and the solid-state, while 6a-c have close to planar conformations, pointing to weak hydrogen bonds between the acidic C-Hs and the adjacent azine nitrogen atoms. The cytotoxicity of the six newly synthesized and three previously prepared compounds was assessed against a human glioblastoma multiforme cell line. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.133
• 作为产物：
  描述：

  吡嗪-2-羧酸甲酯 、 正丁基氯化镁 、 2-碘吡嗪 以 四氢呋喃 为溶剂， 以27%的产率得到二-2-吡嗪基甲酮
  参考文献：
  名称：

  Fused pyrazino[2,3-b]indolizine and indolizino[2,3-b]quinoxaline derivatives; synthesis, structures, and properties

  摘要：

  The synthesis of six new compounds incorporating either a pyrazino[2,3-b]indolizine or indolizino[2,3-b] quinoxaline core are reported in good yield (58-87%). The intermediates for the key cyclization reaction for one set of compounds (5a-c), with a sterically demanding 3,5-dimethylpyrazole group in the 5-position of the core, were found to be mono-substituted. These intermediates could be isolated and cyclized by heating under acid-catalyzed conditions. To further demonstrate the versatility of the chemistry, compounds 6a-c were synthesized in 58-68% yields. Compounds 5a-c are non-planar in solution and the solid-state, while 6a-c have close to planar conformations, pointing to weak hydrogen bonds between the acidic C-Hs and the adjacent azine nitrogen atoms. The cytotoxicity of the six newly synthesized and three previously prepared compounds was assessed against a human glioblastoma multiforme cell line. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2011.09.133

文献信息

• 一种有机化合物及其制备方法、电子传输材料
  申请人：武汉华星光电半导体显示技术有限公司

  公开号：CN113698410A

  公开（公告）日：2021-11-26

  本申请实施例公开了一种有机化合物及其制备方法、电子传输材料；该有机化合物具有如下分子结构式：其中，R1基团和R2基团分别为独立的碳原子数小于15的芳香族化合物或包含氮原子的杂环化合物；本申请提供的该机化合物可形成无定形态膜结构，而且具有大共轭平面构型，有利于电子流动，提高电子传输材料的传输速率，从而提高发光效率，改善显示效果。
• HMG-CoA reductase inhibitors
  申请人：Stein Philip D.

  公开号：US20070249583A1

  公开（公告）日：2007-10-25

  Compounds are provided of the following structure are HMG CoA reductase inhibitors and thus are active in inhibiting cholesterol biosynthesis, modulating blood serum lipids, for example, lowering LDL cholesterol and/or increasing HDL cholesterol, and treating hyperlipidemia and dyslipidemia, hypercholesterolemia, hypertriglyceridemia and atherosclerosis wherein A is chosen from B is chosen from wherein the variables R 1 to R 7 , m, n, are as defined herein. A method for treating the above diseases employing the above compounds is also provided.

  提供以下结构的化合物是HMG CoA还原酶抑制剂，因此在抑制胆固醇生物合成、调节血清脂质，例如降低LDL胆固醇和/或增加HDL胆固醇，以及治疗高脂蛋白血症和血脂异常、高胆固醇血症、高甘油三酯血症和动脉粥样硬化方面具有活性。 其中A选择自 B选择自 其中变量R1至R7，m，n， 如本文所定义。 还提供了一种利用上述化合物治疗上述疾病的方法。
• 一种有机化合物、电致发光材料及其应用
  申请人：武汉天马微电子有限公司

  公开号：CN112079841B

  公开（公告）日：2022-04-26

  本发明提供一种有机化合物、电致发光材料及其应用，所述有机化合物具有如式I所示结构，是一种类咔唑烯烃化合物，分子内基团具有非平面构型，能提高材料的非晶态性能、热稳定性和玻璃化转变温度。所述有机化合物具有合适的HOMO能级、LUMO能级以及较高的三线态能级，可抑制从客体到主体的三线态能量倒流，降低器件的驱动电压。所述有机化合物作为主体材料，具有较高的载流子传输速率以及平衡的载流子传输性能，利于器件中空穴和电子电流的平衡，并获得较宽的载流子复合区域，显著提高器件的发光效率和外量子效率，降低器件的启亮电压和能耗。
• COMPOSITION AND LIGHT-EMITTING ELEMENT COMPRISING THE COMPOSITION
  申请人：Akino Nobuhiko

  公开号：US20100038592A1

  公开（公告）日：2010-02-18

  Disclosed is a composition comprising a compound having a pyrazine ring structure and a phosphorescent compound, wherein the compound having a pyrazine ring structure has a pyrazine ring structure represented by the general formula (1), (2) or (3): wherein R and R 1 independently represent a hydrogen atom or a univalent group and multiple R's and multiple R 1 's may be the same as or different from one another. Also disclosed is a polymer having a residue derived from the phosphorescent compound and the pyrazine ring structure.

  本发明公开了一种化合物组合物，包括具有吡嗪环结构的化合物和磷光化合物，其中具有吡嗪环结构的化合物具有由通式（1）、（2）或（3）表示的吡嗪环结构：其中R和R1分别独立表示氢原子或一价基团，多个R和多个R1可以相同或不同。本发明还公开了一种聚合物，其具有源自磷光化合物和吡嗪环结构的残基。
• Silver(I) coordination networks constructed with di-2-pyrazinylmethanediol
  作者：Chong-Qing Wan、Thomas C.W. Mak

  DOI：10.1016/j.ica.2007.08.002

  日期：2008.4

  The new ligand di-2-pyrazinylmethanone (di-2-pyrazinyl ketone), (2-C4H3N2)(2)CO, has been synthesized, and two silver( I) coordination polymers of its hydrated gem-diol (2-C4H3N2)(2)C(OH)(2), namely Ag[(2-C4H3N2)2C(OH)(2)](CF3SO3)} 1 (1) and Ag[(2-C4H3N2)(2)C( OH)(2)](CF3CO2)} 1 (2), have been characterized by X-ray crystallography. A (4,4) net was found in compound 1. In the case of 2, the silver( I) atom functions as a rare five-connected node to conjunct the (2-C4H3N2)(2)C(OH)2 ligands into an extended coordination network which can be viewed as an alpha-Po topology of the NaCl-type. (c) 2007 Elsevier B. V. All rights reserved.