4-bromo-2-chloro-5-methoxyacetanilide | 188193-11-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-bromo-2-chloro-5-methoxyacetanilide
• 英文别名: N-(4-bromo-2-chloro-5-methoxyphenyl)acetamide
• CAS: 188193-11-5
• 化学式: C₉H₉BrClNO₂
• 分子量: 278.533
• InChiKey: IPMFEDSLMYZWJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-bromo-2-chloro-5-methoxyacetanilide 在 硫酸 、 三溴化硼 、 溶剂黄146 、 三苯基膦 、 偶氮二甲酸二乙酯 作用下， 以 四氢呋喃 、 甲醇 、 二氯甲烷 、 甲苯 为溶剂， 反应 6.5h， 生成 (S)-1-[4-bromo-2-chloro-5-(1-methyl-2-butynyloxy)phenyl]-2,5-dimethylpyrrole
  参考文献：
  名称：

  Synthesis of (S)-N-(endo -8-methyl-8-azabicyclo[3.2.1] oct-3α-yl)-4-amino-5-chloro-2-(1-methyl-2-butynyloxy) [carbonyl-14C]benzamide monohydrochloride (14C-E3620)

  摘要：

  (S)-N-(endo-8-Methyl-8-azabicyclo[3.2.1]oct-3 alpha-yl)-4-amino-5-chloro-2-(1-methyl-2-butnyloxy)[carbonyl-C-14]benzamide monohydrochloride (C-14-E3620, 11), which was required for a study of the pharmacokinetic profile of E3620, is not only a potent antagonist of 5-HT3 receptors but also a potent agonist of 5-HT4 receptors. It was synthesized using (S)-5-chloro-4-(2,5-dimethylpyrrol-1-yl)-2-(1-methyl-2- butynyloxy)[carboxy-C-14]benzoic acid (8) as the labelled starting material.The product was produced at high radiochemical purity with a specific activity of 2.02GBq/mmol.

  DOI：

  10.1002/(sici)1099-1344(199702)39:2<109::aid-jlcr952>3.0.co;2-g
• 作为产物：
  描述：

  N-(2-氯-5-甲氧基苯基)乙酰胺 在 N-溴代丁二酰亚胺(NBS) 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以80%的产率得到4-bromo-2-chloro-5-methoxyacetanilide
  参考文献：
  名称：

  Synthesis of (S)-N-(endo -8-methyl-8-azabicyclo[3.2.1] oct-3α-yl)-4-amino-5-chloro-2-(1-methyl-2-butynyloxy) [carbonyl-14C]benzamide monohydrochloride (14C-E3620)

  摘要：

  (S)-N-(endo-8-Methyl-8-azabicyclo[3.2.1]oct-3 alpha-yl)-4-amino-5-chloro-2-(1-methyl-2-butnyloxy)[carbonyl-C-14]benzamide monohydrochloride (C-14-E3620, 11), which was required for a study of the pharmacokinetic profile of E3620, is not only a potent antagonist of 5-HT3 receptors but also a potent agonist of 5-HT4 receptors. It was synthesized using (S)-5-chloro-4-(2,5-dimethylpyrrol-1-yl)-2-(1-methyl-2- butynyloxy)[carboxy-C-14]benzoic acid (8) as the labelled starting material.The product was produced at high radiochemical purity with a specific activity of 2.02GBq/mmol.

  DOI：

  10.1002/(sici)1099-1344(199702)39:2<109::aid-jlcr952>3.0.co;2-g