N-{2-[2-(2-aminoethoxy)ethoxy]ethyl}acrylamide | 869566-13-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-{2-[2-(2-aminoethoxy)ethoxy]ethyl}acrylamide
• 英文别名: N-[2-[2-(2-aminoethoxy)ethoxy]ethyl]prop-2-enamide
• CAS: 869566-13-2
• 化学式: C₉H₁₈N₂O₃
• 分子量: 202.254
• InChiKey: SRLVTEWXFBVJDO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.1
• 重原子数：
  14
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  73.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3,5-吡啶二甲酰氯 、 N-{2-[2-(2-aminoethoxy)ethoxy]ethyl}acrylamide 在 sodium hydride 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.17h， 以46%的产率得到N³,N⁵-bis{2-[2-(2-acrylamidoethoxy)ethoxy]ethyl}pyridine-3,5-dicarboxamide
  参考文献：
  名称：

  Synthesis of Pyridine Acrylates and Acrylamides and Their Corresponding Pyridinium Ions as Versatile Cross-Linkers for Tunable Hydrogels

  摘要：

  A small library of cross-linkers for hydrogels was synthesized. The cross-linkers consisted of 2,6- and 3,5-diacylpyridine or 2,4,6-triacylpyridine as the core unit, which were tethered via ethylene glycol, amino ethanol, and 1,n-diamine spacers to terminal acrylate or acrylamide moieties. Esterification and amide formation of the terminal acryl units were found to be dependent on the ratio of NH/O in the spacer, the constitution pattern of the pyridine ring, and the total number of acryl groups. Thus, esters generally gave higher yields than amides decreasing with increasing number of NH in the spacer and with increasing number of acryl units. In the case of 3,5-diacylpyridine derivatives, these trends were less prominent as compared to the 2,6-diacylpyridine series, indicating that steric hindrance and unfavorable hydrogen bonding interaction of the spacers might influence the observed reactivity differences. The 3,5-diacylpyridines were converted to the N-methylpyridinium salts and selected members of both neutral and cationic 3,5-diacylpyridinium derivatives were submitted to hydrogelations with synthetic polymer poly(1-glycidylpiperazine) via aza-Michael addition and thiolated natural hyaluronan via thio-Michael reaction, respectively. Rheological properties of the resulting hydrogels were studied, revealing that both spacer type as well as charge affected elastic moduli and degree of swelling.

  DOI：

  10.1055/s-0033-1338614
• 作为产物：
  描述：

  1,8-二氨基-3,6-二氧杂辛烷 在 盐酸 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 9.0h， 生成 N-{2-[2-(2-aminoethoxy)ethoxy]ethyl}acrylamide
  参考文献：
  名称：

  Synthesis of Pyridine Acrylates and Acrylamides and Their Corresponding Pyridinium Ions as Versatile Cross-Linkers for Tunable Hydrogels

  摘要：

  A small library of cross-linkers for hydrogels was synthesized. The cross-linkers consisted of 2,6- and 3,5-diacylpyridine or 2,4,6-triacylpyridine as the core unit, which were tethered via ethylene glycol, amino ethanol, and 1,n-diamine spacers to terminal acrylate or acrylamide moieties. Esterification and amide formation of the terminal acryl units were found to be dependent on the ratio of NH/O in the spacer, the constitution pattern of the pyridine ring, and the total number of acryl groups. Thus, esters generally gave higher yields than amides decreasing with increasing number of NH in the spacer and with increasing number of acryl units. In the case of 3,5-diacylpyridine derivatives, these trends were less prominent as compared to the 2,6-diacylpyridine series, indicating that steric hindrance and unfavorable hydrogen bonding interaction of the spacers might influence the observed reactivity differences. The 3,5-diacylpyridines were converted to the N-methylpyridinium salts and selected members of both neutral and cationic 3,5-diacylpyridinium derivatives were submitted to hydrogelations with synthetic polymer poly(1-glycidylpiperazine) via aza-Michael addition and thiolated natural hyaluronan via thio-Michael reaction, respectively. Rheological properties of the resulting hydrogels were studied, revealing that both spacer type as well as charge affected elastic moduli and degree of swelling.

  DOI：

  10.1055/s-0033-1338614

文献信息

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  DOI：10.1039/c6tb03198f

  日期：——

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• 一种N-端胺基聚醚基丙烯酰胺单体及其制备 方法
  申请人：中国石油化工股份有限公司

  公开号：CN104926678B

  公开（公告）日：2017-02-08

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• Synthesis, characterization and biological evaluation of a new photoactive hydrogel against Gram-positive and Gram-negative bacteria
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  DOI：10.1039/c5tb02569a

  日期：——

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• Inkjet fabrication of hydrogel microarrays using in situ nanolitre-scale polymerisation
  作者：Rong Zhang、Albert Liberski、Ferdous Khan、Juan Jose Diaz-Mochon、Mark Bradley

  DOI：10.1039/b717932d

  日期：——

  Polymer hydrogel microarrays were fabricated by inkjet printing of monomers and initiator, allowing up to 1800 individual polymer features to be printed on a single glass slide.

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• NUCLEIC ACID AMPLIFICATION
  申请人：Life Technologies Corporation

  公开号：EP3461910A1

  公开（公告）日：2019-04-03

  In some embodiments, the present teachings provide methods for nucleic acid amplification, comprising forming an reaction mixture, and subjecting the reaction mixture to conditions suitable for nucleic acid amplification. In some embodiments, methods for nucleic acid amplification include subjecting the nucleic acid to be amplified to partially denaturing conditions. In some embodiments, methods for nucleic acid amplification include amplifying without fully denaturing the nucleic acid that is amplified. In some embodiments, the methods for nucleic acid amplification employ an enzyme that catalyzes homologous recombination and a polymerase. In some embodiments, methods for nucleic acid amplification can be conducted in a single reaction vessel. In some embodiments, methods for nucleic acid amplification can be conducted in a single continuous liquid phase of an reaction mixture, without need for compartmentalization of the reaction mixture or immobilization of reaction components. In some embodiments, methods for nucleic acid amplification comprise a amplifying at least one polynucleotide onto a surface under isothermal amplification conditions, optionally in the presence of a polymer. The polymer can include a sieving agent and/or a diffusion-reducing agent.

  在一些实施例中，本教导提供了核酸扩增的方法，包括形成反应混合物，并将反应混合物置于适合核酸扩增的条件下。在一些实施方案中，核酸扩增方法包括将待扩增核酸置于部分变性条件下。在一些实施方案中，核酸扩增的方法包括在不使被扩增核酸完全变性的情况下进行扩增。在某些实施方案中，核酸扩增方法采用催化同源重组的酶和聚合酶。在某些实施方案中，核酸扩增方法可在单个反应容器中进行。在某些实施方案中，核酸扩增方法可在反应混合物的单一连续液相中进行，无需对反应混合物进行分隔或固定反应成分。在某些实施方案中，核酸扩增方法包括在等温扩增条件下，将至少一种多核苷酸扩增到表面上，可选择在有聚合物存在的情况下进行。聚合物可包括筛分剂和/或扩散减少剂。