4-(2-Hydroxyethylthio)buttersaeure | 64157-91-1

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-(2-Hydroxyethylthio)buttersaeure
• 英文别名: 4-(2-Hydroxyethylsulfanyl)butanoic acid
• CAS: 64157-91-1
• 化学式: C₆H₁₂O₃S
• 分子量: 164.225
• InChiKey: CVGNLGCYCJRGFK-UHFFFAOYSA-N

物化性质

• 沸点：
  370.6±22.0 °C(Predicted)
• 密度：
  1.228±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  10
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  82.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  4-(2-Hydroxyethylthio)buttersaeure 在 氯化亚砜 作用下， 以 丙酮 、 苯 为溶剂， 生成 4-[(2-Chloroethyl)sulfanyl]-N-(4-hydroxyphenyl)butanamide
  参考文献：
  名称：

  Chemoimmunotherapy of cancer. 2

  摘要：

  The preparation of a series of water-soluble mustard haptens for chemoimmunotherapy of cancer is described. Preliminary screening data are given, indicating some activity against P388 lymphocytic leukemia for those compounds containing the most potent immunogenic functional groups.

  DOI：

  10.1021/jm00221a001
• 作为产物：
  描述：

  ethyl 4-(2-hydroxyethylthio)-butyrate 在 sodium hydroxide 作用下， 以 乙醇 为溶剂， 生成 4-(2-Hydroxyethylthio)buttersaeure
  参考文献：
  名称：

  Chemoimmunotherapy of cancer. 2

  摘要：

  The preparation of a series of water-soluble mustard haptens for chemoimmunotherapy of cancer is described. Preliminary screening data are given, indicating some activity against P388 lymphocytic leukemia for those compounds containing the most potent immunogenic functional groups.

  DOI：

  10.1021/jm00221a001

文献信息

• SUBSTITUTED ACETAMIDE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND ANTIULCER DRUG CONTAINING SAME
  申请人：ZERIA PHARMACEUTICAL CO., LTD.

  公开号：EP0404949A1

  公开（公告）日：1991-01-02

  This invention relates to substituted acetamide derivatives represented by general formula (I), salts thereof, cyclodextrin inclusion compounds thereof, and an antiulcer drug containing same as an active ingredient, wherein Y represents a piperidino group, a 1-pyrrolidinyl group or a 3-hydroxy-1-pyrrolidinyl group, and Z represents a group selected from among groups (a) to (e): (a) cyano group, (b), (c), (d) and (e). The compounds (I) possess an excellent antiulcer activity and a high safty, and hence an antiulcer drug containing same is useful as a drug for prophylaxis and treatment of acute or chronic gastric ulcer, duodenal ulcer, gastritis and hyperacidity.

  本发明涉及通式(I)代表的取代乙酰胺衍生物、其盐、环糊精包合物，以及以其为有效成分的抗溃疡药物，其中Y代表哌啶基、1-吡咯烷基或3-羟基-1-吡咯烷基，Z代表选自(a)至(e)组的基团：(a)氰基、(b)、(c)、(d)和(e)。化合物(I)具有优异的抗溃疡活性和高安全性，因此，含有该化合物的抗溃疡药物可作为预防和治疗急性或慢性胃溃疡、十二指肠溃疡、胃炎和胃酸过多的药物。
• OZONIDE REDUCING AGENT
  申请人：OTSUKA KAGAKU KABUSHIKI KAISHA

  公开号：EP0686613A1

  公开（公告）日：1995-12-13

  An ozonide reducing agent to be used in the ozonolysis of organic compounds, which has a wide application area and is industrially safe, inexpensive, and easy to aftertreat. The agent is a compound bearing a sulfur atom and, bonded thereto, two hydrocarbon radicals substituted by polar functional groups.

  一种用于有机化合物臭氧分解的臭氧还原剂，其应用领域广泛，在工业上安全、廉价且易于后处理。该还原剂是一种含有一个硫原子和两个被极性官能团取代的烃基键合的化合物。
• US5770729A
  申请人：——

  公开号：US5770729A

  公开（公告）日：1998-06-23
• Chemoimmunotherapy of cancer. 2
  作者：A. H. Soloway、J. E. Wright、V. Subramanyam、J. J. Gozzo

  DOI：10.1021/jm00221a001

  日期：1977.11

  The preparation of a series of water-soluble mustard haptens for chemoimmunotherapy of cancer is described. Preliminary screening data are given, indicating some activity against P388 lymphocytic leukemia for those compounds containing the most potent immunogenic functional groups.