8-Hydrazinyl-8-oxooctanoic acid | 209055-42-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 8-Hydrazinyl-8-oxooctanoic acid
• CAS: 209055-42-5
• 化学式: C₈H₁₆N₂O₃
• 分子量: 188.227
• InChiKey: WSPHEJHQBNDYMI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  92.4
• 氢给体数：
  3
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  methyl 8-hydrazinyl-8-oxooctanoate 在 水 、 sodium hydroxide 、 potassium hydrogensulfate 作用下， 以 甲醇 、 水 为溶剂， 反应 12.0h， 生成 8-Hydrazinyl-8-oxooctanoic acid
  参考文献：
  名称：

  Discovery of histone deacetylase 8 selective inhibitors

  摘要：

  We have developed an efficient method for synthesizing candidate histone deacetylase ( HDAC) inhibitors in 96-well plates, which are used directly in high-throughput screening. We selected building blocks having hydrazide, aldehyde and hydroxamic acid functionalities. The hydrazides were coupled with different aldehydes in DMSO. The resulting products have the previously identified 'cap/linker/biasing element' structure known to favor inhibition of HDACs. These compounds were assayed without further purification. HDAC8-selective inhibitors were discovered from this novel collection of compounds. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.01.134

文献信息

• POLYACETAL RESIN COMPOSITION AND METHOD FOR PRODUCING THE SAME
  申请人：Asahi Kasei Chemicals Corporation

  公开号：EP2267075A1

  公开（公告）日：2010-12-29

  Provided is a polyacetal resin composition obtained from a raw material composition containing a polyacetal resin, a hydrazine derivative, and a compound for lowering the melting point of the hydrazine derivative, wherein a mixture of the hydrazine derivative and the compound satisfies both of the following conditions: T1

  本发明提供了一种聚缩醛树脂组合物，该组合物由包含聚缩醛树脂、肼衍生物和用于降低肼衍生物熔点的化合物的原料组合物获得，其中肼衍生物和化合物的混合物满足以下两个条件：T1＜T2和T1＜T3，其中T1是混合物具有最大内热容量的内热峰的顶点温度，通过DSC，按照预定的温度程序加热和冷却混合物，然后以预定的速率加热，直到混合物熔化；T2和T3分别代表通过类似处理具有最大内热容量的肼衍生物和聚甲醛树脂的内热峰的顶点温度。
• POLYACETAL RESIN COMPOSITION AND MOLDED BODY THEREOF
  申请人：Asahi Kasei Kabushiki Kaisha

  公开号：EP3354688A1

  公开（公告）日：2018-08-01

  A polyacetal resin composition has very excellent durability, which includes 100 parts by mass of a polyacetal resin (A) and 10 parts by mass or more and 100 parts by mass or less of a glass filler (B), wherein when a polyacetal resin molded article (C) made of the polyacetal resin composition is washed with a mixed solvent of hexafluoroisopropanol and chloroform in 1/1 (volume ratio), the remaining residue (D) has an ignition loss of 0.2% by weight or more.

  一种具有极佳耐久性的聚缩醛树脂组合物，其中包括 100 份（质量）的聚缩醛树脂（A）和 10 份（质量）以上、100 份（质量）以下的玻璃填料（B），当用该聚缩醛树脂组合物制成的聚缩醛树脂模塑制品（C）用六氟异丙醇和氯仿以 1/1（体积比）的混合溶剂洗涤时，剩余残留物（D）的点火损失为 0.2%（质量）或以上、 剩余残留物 (D) 的点火损失为 0.2% （重量比）或以上。
• Method for manufacturing high purity glycol based compound
  申请人：Samsung Display Co. Ltd.

  公开号：US10040741B2

  公开（公告）日：2018-08-07

  Provided is a method for manufacturing a glycol based compound. The method comprises agitating a mixture of a first glycol based compound, a hydrazide based compound, and a sulfonic acid based compound, and performing fractional distillation of resultant materials of the agitating to recover a second glycol based compound having a formaldehyde content of 0 ppm.

  本发明提供了一种制造乙二醇基化合物的方法。该方法包括搅拌第一种乙二醇基化合物、酰肼基化合物和磺酸基化合物的混合物，并对搅拌所得物料进行分馏，以回收甲醛含量为 0 ppm 的第二种乙二醇基化合物。
• POLYACETAL RESIN COMPOSITION AND PREPARATION PROCESS THEREOF
  申请人：Iwamoto Takashi

  公开号：US20110015321A1

  公开（公告）日：2011-01-20

  Provided is a polyacetal resin composition obtained from a raw material composition containing a polyacetal resin, a hydrazine derivative, and a compound for lowering the melting point of the hydrazine derivative, wherein a mixture of the hydrazine derivative and the compound satisfies both of the following conditions: T1
• METHOD FOR MANUFACTURING HIGH PURITY GLYCOL BASED COMPOUND
  申请人：Samsung Display Co. Ltd.

  公开号：US20160297732A1

  公开（公告）日：2016-10-13

  Provided is a method for manufacturing a glycol based compound. The method comprises agitating a mixture of a first glycol based compound, a hydrazide based compound, and a sulfonic acid based compound, and performing fractional distillation of resultant materials of the agitating to recover a second glycol based compound having a formaldehyde content of 0 ppm.