(1-Azido-2-phenylethoxy)cyclododecane | 1159003-95-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (1-Azido-2-phenylethoxy)cyclododecane
• 英文别名: (1-azido-2-phenylethoxy)cyclododecane
• CAS: 1159003-95-8
• 化学式: C₂₀H₃₁N₃O
• 分子量: 329.486
• InChiKey: GVHSVPYYVBMEKH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.1
• 重原子数：
  24
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  23.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  1-辛炔 、 (1-Azido-2-phenylethoxy)cyclododecane 在 铜 作用下， 以 乙腈 为溶剂， 反应 13.0h， 生成 1-(1-Cyclododecyloxy-2-phenylethyl)-4-hexyltriazole
  参考文献：
  名称：

  Cu(OTf)2/Cu-catalyzed four-component reaction: a facile synthesis of α-alkoxytriazoles via click chemistry

  摘要：

  Aldehyde, alcohol, azide, and alkyne undergo smooth coupling by means of acetal formation, azidation, and a Subsequent 'click reaction' in the presence of copper(II) triflate and copper metal in acetonitrile to furnish alpha-alkoxy-1,2,3-triazoles in good yields. The method provides a convenient route to prepare a wide range of triazoles in a one-pot operation via a four-component reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.027
• 作为产物：
  描述：

  环十二醇 、 苯乙醛 在 叠氮基三甲基硅烷 、 copper(II) bis(trifluoromethanesulfonate) 作用下， 以 乙腈 为溶剂， 生成 (1-Azido-2-phenylethoxy)cyclododecane
  参考文献：
  名称：

  Cu(OTf)2/Cu-catalyzed four-component reaction: a facile synthesis of α-alkoxytriazoles via click chemistry

  摘要：

  Aldehyde, alcohol, azide, and alkyne undergo smooth coupling by means of acetal formation, azidation, and a Subsequent 'click reaction' in the presence of copper(II) triflate and copper metal in acetonitrile to furnish alpha-alkoxy-1,2,3-triazoles in good yields. The method provides a convenient route to prepare a wide range of triazoles in a one-pot operation via a four-component reaction. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2009.08.027

文献信息

• Cu(OTf)2/Cu-catalyzed four-component reaction: a facile synthesis of α-alkoxytriazoles via click chemistry
  作者：J.S. Yadav、B.V. Subba Reddy、G. Madhusudhan Reddy、S. Rehana Anjum

  DOI：10.1016/j.tetlet.2009.08.027

  日期：2009.11

  Aldehyde, alcohol, azide, and alkyne undergo smooth coupling by means of acetal formation, azidation, and a Subsequent 'click reaction' in the presence of copper(II) triflate and copper metal in acetonitrile to furnish alpha-alkoxy-1,2,3-triazoles in good yields. The method provides a convenient route to prepare a wide range of triazoles in a one-pot operation via a four-component reaction. (C) 2009 Elsevier Ltd. All rights reserved.