3α-Hydroxyandrosten-(5) | 5232-33-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3α-Hydroxyandrosten-(5)
• 英文别名: (3R,8S,9S,10R,13S,14S)-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 5232-33-7
• 化学式: C₁₉H₃₀O
• 分子量: 274.447
• InChiKey: LYFPAZBMEUSVNA-UGCZWRCOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  3β,5α-dihydroxyandrostane 在 吡啶 作用下， 生成 3α-Hydroxyandrosten-(5)
  参考文献：
  名称：

  Synthesis and infrared spectra of some 3α-hydroxy Δ5-steroids

  摘要：

  DOI：

  10.1016/0039-128x(65)90093-0

文献信息

• METHODS AND COMPOUNDS FOR PREPARING 3ALPHA-OXYGEN SUBSTITUTED STEROIDS
  申请人：Ge Yu

  公开号：US20120214987A1

  公开（公告）日：2012-08-23

  The invention relates to processes for preparing 3α-O-linked steroids including 3α-O-linked-androst-5-ene steroids and 3α-O-linked-5a-androstane steroids. In one process a 3α,4α-epoxy androst-5-en-17-one is predominately reduced at the epoxy moiety wherein reduction of the 3α,4α epoxy functional group occurs preferentially at position C4 with retention of configuration at position C3 to provide a 3α-O-linked-androst-5-ene steroid. In another process, conditions are provided for inversion of configuration of a 3β-hydroxy-androst-5-ene steroid by the Mitsunobu reaction to provide a 3α-O-linked-androst-5-ene steroid with reduced amounts of 3α,5α-cycloandrostane side-product impurities.

  该发明涉及制备3α-O-连接类固醇的过程，包括3α-O-连接-雄烯类固醇和3α-O-连接-5α-雄烷类固醇。在一个过程中，3α,4α-环氧基雄-5-烯-17-酮主要在环氧基团处还原，其中3α,4α-环氧官能团的还原优先发生在C4位置，并保留C3位置的构型，以提供3α-O-连接-雄烯类固醇。在另一个过程中，通过Mitsunobu反应提供条件，使3β-羟基雄-5-烯类固醇的构型发生倒置，以提供含有减少量3α,5α-环雄烷副产物杂质的3α-O-连接-雄烯类固醇。
• A mild method for the preparation of unsaturated alcohols from 1,3-glycols via dimethylformamide acetals
  作者：Mark J. Ackland、John F. Gordon、James R. Hanson、Boon Leng Yeoh、Arnold H. Ratcliffe

  DOI：10.1039/c39870001756

  日期：——

  Provided it possesses a hydrogen atom suitably placed for elimination, a 1,3-glycol may be converted into an unsaturated alcohol via quaternization of its dimethylformamide acetal.

  如果其具有适合放置用于除去的氢原子，则可以通过其二甲基甲酰胺缩醛的季铵化将1，3-乙二醇转化为不饱和醇。
• Ackland, Mark J.; Gordon, John F.; Hanson, James R., Journal of the Chemical Society. Perkin transactions I, 1988, p. 2013 - 2018
  作者：Ackland, Mark J.、Gordon, John F.、Hanson, James R.、Yeoh, Boon Leng、Ratcliffe, Arnold H.

  DOI：——

  日期：——
• ACKLAND, MARK J.;GORDON, JOHN F.;HANSON, JAMES R.;YEOH, BOON LENG;RATCLIF+, J. CHEM. SOC. PERKIN TRANS. PT 1,(1988) N 7, C. 2013-2017
  作者：ACKLAND, MARK J.、GORDON, JOHN F.、HANSON, JAMES R.、YEOH, BOON LENG、RATCLIF+

  DOI：——

  日期：——
• PHARMACEUTICAL COMPOSITIONS
  申请人：Shenzhen Pharmacin Co., Ltd.

  公开号：US20200237784A1

  公开（公告）日：2020-07-30

  Provided are pharmaceutical compositions which comprise a mixture of a lipophilic active pharmaceutical ingredient, at least one long chain fatty acid or at least one fatty acid glyceride, a surfactant, and optionally an antioxidant. Also described are methods for preparing and using such pharmaceutical compositions. The active pharmaceutical ingredient in such a combination has improved bioavailability compared to the active pharmaceutical ingredient alone.