(E)-4,5-二氧代十六碳-2-烯酸 | 135863-69-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 中文名称: (E)-4,5-二氧代十六碳-2-烯酸
• 英文名称: podoscyphic acid
• 英文别名: (E)-4,5-dioxohexadec-2-enoic acid
• CAS: 135863-69-3
• 化学式: C₁₆H₂₆O₄
• 分子量: 282.38
• InChiKey: PWWAQDKNDPWXOO-OUKQBFOZSA-N

物化性质

• 沸点：
  414.1±37.0 °C(Predicted)
• 密度：
  1.026±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  71.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1-benzyl-2-(ethoxycarbonylmethylene)-2,3,4,5-tetrahydroimidazole 、 (E)-4,5-二氧代十六碳-2-烯酸 在 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以83%的产率得到1-benzyl-5-dodecanoyl-5-hydroxy-1,2,3,5,6,7-hexahydro-imidazo[1,2-a]pyridine-7,8-dicarboxylic acid 8-ethyl ester
  参考文献：
  名称：

  Imidazo[1,2-a]pyridine derivatives as inhibitors of TNF-α expression in T cells

  摘要：

  Novel hexahydroimidazo[1,2-a]pyridines prepared by the addition of ethyl (1-benzylimidazolidin-2-ylidene)acetate (2) to the fungal metabolite podoscyphic acid (1a) and esters of la have been evaluated for their ability to inhibit the inducible TNF-alpha promoter activity in T cells. The methyl ester 3b is the most potent, inhibiting the TNF-alpha driven reporter gene expression in Jurkat T cells with an IC50-value of 2.0 mu g/ml (3.6 mu M). In addition, compound 3b inhibited the inducible TNF-alpha production in the myelomonocytic U937 cells with an IC50-value of 4.6 mu M. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.074
• 作为产物：
  描述：

  十二醛 在 奎宁环 、 甲基磺酰胺 Candida antarctica lipase B 、 2,2,6,6-tetramethyl-piperidine-N-oxyl 、 四氧化锇 、 potassium carbonate 、 potassium hexacyanoferrate(III) 、 lithium diisopropyl amide 作用下， 以 四氢呋喃 、 二氯甲烷 、 水 、 叔丁醇 为溶剂， 反应 98.0h， 生成 (E)-4,5-二氧代十六碳-2-烯酸
  参考文献：
  名称：

  Synthesis of podoscyphic acid

  摘要：

  Podoscyphic acid 1, a fungal metabolite inhibiting RNA-directed DNA polymerises, was synthesised in four steps starting from dodecanal. The concluding ester hydrolysis of 4 was not feasible with chemical reagents, only enzymatic hydrolysis was mild enough to release the highly reactive natural product in good yields. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4039(01)02264-x

文献信息

• Process for producing polyamide
  申请人：MITSUBISHI KASEI CORPORATION

  公开号：EP0221755A2

  公开（公告）日：1987-05-13

  A process for producing a polyamide while defoaming the bubbles formed during the process comprises polymerizing at least one monomer therefor in the presence of: (1) a hydrocarbon polymer bearing at least one type of group selected from carboxyl, carboxylic acid derivative, amino and hydroxyl groups, or (2) a polymer produced by reacting a said hydrocarbon polymer with a polyamide, or polymerizing at least one polyamide monomer in the presence of the hydrocarbon polymer.

  一种生产聚酰胺的工艺，同时对该工艺中形成的气泡进行消泡，该工艺包括在以下物质存在的情况下聚合至少一种聚酰胺单体： (1) 至少带有一种选自羧基、羧酸衍生物、氨基和羟基的基团的烃聚合物，或 (2) 上述烃类聚合物与聚酰胺反应生成的聚合物，或至少一种聚酰胺单体在烃类聚合物存在下聚合。
• Resin composition and shaped article thereof
  申请人：Mitsubishi Chemical Corporation

  公开号：EP0403109A2

  公开（公告）日：1990-12-19

  Disclosed is a resin composition comprised of (a) 5 to 95 weight % of a saponified ethylene/vinyl acetate copolymer, (b) 95 to 5 weight % of a polyamide resin in which the content (in µ-equivalent/g of the polymer) of the terminal amino group in the molecule is larger than the content (in µ-equivalent/g of the polymer) of the terminal carboxyl group in the molecule, and (c) 0.5 to 10 weight % of a modified polyolefin formed by grafting an unsaturated carboxylic acid, or an acid anhydride or salt thereof onto a polyolefin. The resin composition can be stably shaped for a long time by extrusion.

  本发明公开了一种树脂组合物，其成分包括：(a) 5 至 95 重量％的皂化乙烯/醋酸乙烯共聚物；(b) 95 至 5 重量％的聚酰胺树脂，其中分子中末端氨基的含量（以微当量/克聚合物计）大于分子中末端羧基的含量（以微当量/克聚合物计）；以及 (c) 0.5 至 10 重量％的改性聚烯烃，该改性聚烯烃是通过将不饱和羧酸或酸酐或其盐接枝到聚烯烃上形成的。这种树脂组合物可以通过挤压长期稳定成型。
• LAMINATE
  申请人：The Nippon Synthetic Chemical Industry Co., Ltd.

  公开号：EP1698458A1

  公开（公告）日：2006-09-06

  The present invention relates to a laminated article excellent in appearance at a retort treatment, delamination resistance, gas barrier property, further, long-run processability, performance of preventing odor and coloring and the like. The laminated article of the present invention is characterized in comprising a layer (I) containing a saponified product of an ethylene-vinyl acetate copolymer (A) and a polyamide resin (B) and a layer (II) of a polyamide resin (C) which is adjacent to the layer (I) directly or via an adhesive resin layer, wherein the saponified product of an ethylene-vinyl acetate copolymer (A) contains a sodium salt (M1) and a bivalent metal salt (M2), and an amount ratio (M1/M2) of the sodium salt (M1) to the bivalent metal salt (M2) is 0.01 to 15 calculated in terms of metal weight, further comprising 3 to 50 ppm of a phosphorus compound calculated in terms of phosphorus and 10 to 1000 ppm of a hindered phenol antioxidant.

  本发明涉及一种层压制品，该制品在蒸煮处理时外观、抗分层性、气体阻隔性、进一步的长期加工性、防止异味和着色性能等方面都非常出色。本发明的层压制品的特点是包括一层（I），其中含有乙烯-醋酸乙烯共聚物（A）和聚酰胺树脂（B）的皂化产物；以及一层（II），其中含有聚酰胺树脂（C），该层直接或通过粘合树脂层与层（I）相邻、其中乙烯-醋酸乙烯共聚物(A)的皂化产物含有钠盐(M1)和二价金属盐(M2)，钠盐(M1)与二价金属盐(M2)的量比(M1/M2)为 0.01至15，进一步包含以磷计算的3至50ppm的磷化合物和10至1000ppm的受阻酚抗氧化剂。
• Laminated article
  申请人：Onishi Hideshi

  公开号：US20070148481A1

  公开（公告）日：2007-06-28

  A disclosed laminated article is excellent in appearance at a retort treatment, delamination resistance, gas barrier property, further, long-run processability, performance of preventing odor and coloring and the like. The laminated article includes a layer (I) containing a saponified product of an ethylene-vinyl acetate copolymer (A) and a polyamide resin (B) and a layer (II) of a polyamide resin (C) which is adjacent to the layer (I) directly or via an adhesive resin layer, wherein the saponified product of an ethylene-vinyl acetate copolymer (A) contains a sodium salt (M1) and a bivalent metal salt (M2), and an amount ratio (M1/M2) of the sodium salt (M1) to the bivalent metal salt (M2) is 0.01 to 15 calculated in terms of metal weight, further comprising 3 to 50 ppm of a phosphorus compound calculated in terms of phosphorus and 10 to 1000 ppm of a hindered phenol antioxidant.
• US4810753A
  申请人：——

  公开号：US4810753A

  公开（公告）日：1989-03-07