dimethyl 2,6-dimethyl-4-(2-methylpropyl)-3,5-pyridinedicarboxylate | 121195-87-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: dimethyl 2,6-dimethyl-4-(2-methylpropyl)-3,5-pyridinedicarboxylate
• 英文别名: 4-isobutyl-3,5-dimethoxycarbonyl-2,6-dimethylpyridine；Dimethyl 4-isobutyl-2,6-dimethyl-3,5-pyridinedicarboxylate；dimethyl 2,6-dimethyl-4-(2-methylpropyl)pyridine-3,5-dicarboxylate
• CAS: 121195-87-7
• 化学式: C₁₅H₂₁NO₄
• 分子量: 279.336
• InChiKey: XCWLZAGJYQKXGJ-UHFFFAOYSA-N

物化性质

• 沸点：
  363.1±42.0 °C(Predicted)
• 密度：
  1.086±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  20
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  65.5
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  dimethyl 2,6-dimethyl-4-(2-methylpropyl)-3,5-pyridinedicarboxylate 在 氯化亚砜 作用下， 以 氯苯 为溶剂， 反应 5.0h， 以2.69 g的产率得到dimethyl 2-methyl-4-(2-methylpropyl)-6-(trichloromethyl)-3,5-pyridinedicarboxylate
  参考文献：
  名称：

  Chupp, John P.; Smith, Lowell R., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1785 - 1792

  摘要：

  DOI：
• 作为产物：
  描述：

  乙酰乙酸甲酯 、 异戊醛 在 氨 、 二乙胺 作用下， 以 甲醇 为溶剂， 生成 dimethyl 2,6-dimethyl-4-(2-methylpropyl)-3,5-pyridinedicarboxylate
  参考文献：
  名称：

  Chupp, John P.; Smith, Lowell R., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1785 - 1792

  摘要：

  DOI：

文献信息

• Electrochemical oxidation of 4-monoalkyl-substituted 1,4-dihydropyridines
  作者：B. Turovska、I. Goba、I. Turovskis、S. Grinberga、S. Belyakov、S. Stupnikova、E. Liepinsh、J. Stradins

  DOI：10.1007/s10593-009-0211-0

  日期：2008.12

  The electrochemical oxidation of 4-monoalkyl-substituted 1,4-dihydropyridines has been studied in an aprotic medium and in the presence of pyridine. In an aprotic medium the products of oxidation are both 4-alkyl-substituted and 4-unsubstituted pyridines or mixtures of them. On oxidation in acetonitrile of 4-Et-, 4-n-Pr-, and 4-i-Bu-substituted dihydropyridines, 2-methylene-1,2,3,4-tetrahydropyridines were obtained in addition to the oxidized forms. In the presence of base the products of preparative electrolysis of the studied compounds were 4-alkyl-substituted pyridines. The exception was the 4-i-Pr- substituted dihydropyridine which was dealkylated on oxidation even in the presence of base.
• CHUPP, JOHN P.;SMITH, LOWELL R., J. HETEROCYCL. CHEM., 25,(1988) N, C. 1785-1792
  作者：CHUPP, JOHN P.、SMITH, LOWELL R.

  DOI：——

  日期：——
• Chupp, John P.; Smith, Lowell R., Journal of Heterocyclic Chemistry, 1988, vol. 25, p. 1785 - 1792
  作者：Chupp, John P.、Smith, Lowell R.

  DOI：——

  日期：——