α,α'-Dithio-dibuttersaeure | 90114-01-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: α,α'-Dithio-dibuttersaeure
• 英文别名: (+/-)-2,5-diethyl-3,4-dithia-adipic acid；(+/-)-2,5-Diaethyl-3,4-dithia-adipinsaeure；2,2'-Disulfanediyldibutanoic acid；2-(1-carboxypropyldisulfanyl)butanoic acid
• CAS: 90114-01-5
• 化学式: C₈H₁₄O₄S₂
• 分子量: 238.329
• InChiKey: YPISROXAISJWDA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  14
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  125
• 氢给体数：
  2
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  溶剂黄146 、 α,α'-Dithio-dibuttersaeure 、 alkaline earth salt of/the/ methylsulfuric acid 生成 2-巯基丁酸
  参考文献：
  名称：

  Price; Twiss, Journal of the Chemical Society, 1909, vol. 95, p. 1054

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 manganese(II) sulfate 、 氧气 作用下， 生成 α,α'-Dithio-dibuttersaeure
  参考文献：
  名称：

  Ahlberg, Journal fur praktische Chemie (Leipzig 1954), 1933, vol. <2>138, p. 137,140

  摘要：

  DOI：

文献信息

• Particulate filler and polymer composition containing the filler
  申请人：IMPERIAL CHEMICAL INDUSTRIES PLC

  公开号：EP0038620A2

  公开（公告）日：1981-10-28

  A coated particulate filler having bound thereto a material comprising an acidic group reactive with the filler and a sulphur-containing group which is not reactive with the filler but which is decomposable to a sulphur-containing species which is capable of taking part in a sulphur-based curing reaction, a composition containing the filler and an organic polymeric material which contains ethylenic unsaturation and which is curable by reaction with sulphur, a process for producing the coated particulate filler, and a process for producing the composition.

  一种有涂层的微粒填料，其上结合了一种材料，该材料包含一个与填料反应的酸性基团和一个不与填料反应但可分解为能够参与硫基固化反应的含硫物质的含硫基团；一种组合物，其中包含填料和一种含有乙烯不饱和度且可与硫反应固化的有机聚合物材料；一种生产有涂层的微粒填料的工艺；以及一种生产该组合物的工艺。
• Dithiodialkanoamidophenol compounds and organic material stabilized therewith
  申请人：Mallinckrodt, Inc. (a Delaware corporation)

  公开号：EP0191983A1

  公开（公告）日：1986-08-27

  Multifunctional dithiodialkanoamidophenol compounds useful in the stabilization of organic materials normally susceptible to oxidative degradation are prepared by contacting a selected dithiodialkanoic acid chloride with a selected alkylaminophenol under amide-forming reaction conditions. In a preferred embodiment, the compound is N,N'-bis(3',5'-di-t-butyl-4'-hydroxyphenyl)-3,4-dithiahexane-1,6-dicarboxamide.

  在酰胺化反应条件下，将选定的二硫代二烷基氯化酸与选定的烷基氨基苯酚接触，可制备出有助于稳定通常易氧化降解的有机材料的多功能二硫代二烷基氨基苯酚化合物。在一个优选的实施方案中，该化合物是 N,N'-双(3',5'-二叔丁基-4'-羟基苯基)-3,4-二硫杂己烷-1,6-二甲酰胺。
• WATER-SOLUBLE METALWORKING FLUID, AND METALWORKING COOLANT
  申请人：Idemitsu Kosan Co., Ltd

  公开号：EP3124583A1

  公开（公告）日：2017-02-01

  A water-soluble metalworking fluid of the invention contains: a component (A) that is a dicarboxylic acid including a sulfide structure; a component (B) that is a polyalkylene glycol; a component (C) that is polyhydric alcohol polyalkylene oxide adducts; and a component (D) that is a monocarboxylic acid.

  本发明的一种水溶性金属加工液含有：包括硫化物结构的二羧酸成分（A）；聚烷基乙二醇成分（B）；多羟基乙醇聚氧化烯加合物成分（C）；以及单羧酸成分（D）。
• WATER-SOLUBLE METALWORKING OIL, AND METALWORKING COOLANT
  申请人：Idemitsu Kosan Co., Ltd

  公开号：EP3124584A1

  公开（公告）日：2017-02-01

  A water-soluble metalworking fluid of the invention contains a component (A) that is a dicarboxylic acid including a sulfide structure and a component (B) that is a monocarboxylic acid, in which the fluid contains no polyalkylene glycol. A metalworking coolant of the invention is provided by diluting the above-described water-soluble metalworking fluid with water.

  本发明的一种水溶性金属加工液含有包括硫化物结构的二羧酸成分（A）和单羧酸成分（B），其中该金属加工液不含有聚亚烷基二醇。通过用水稀释上述水溶性金属加工液，可提供本发明的金属加工冷却剂。
• LYMPHATIC MEDIATED TRANSPORT-BASED TRIGLYCERIDE PRODRUG, AND PREPARATION METHOD THEREFOR
  申请人：Shenyang Pharmaceutical University

  公开号：EP3919481A1

  公开（公告）日：2021-12-08

  The present invention relates to the technical field of pharmacy, relates to a lymphatic mediated transport-based triglyceride prodrug, and specifically relates to a triglyceride prodrug of different joining chains in a lymphatic mediated transport, the preparation thereof and an application thereof in drug delivery. The present invention provides a prodrug of different connection bonds and a synthesis method therefor. The structure of the prodrug is as shown below. X, R1, R2, n, and m are described in the claims and description. According to the prodrug provided by the present invention, the digestion and absorption mechanism of glycerol in the gastrointestinal tract is simulated by using the structure of triglycerides, the lymphatic transport of drugs is promoted, the first pass effect is avoided, and the prodrug has the targeting property and can obviously enhance or improve the drug oral bioavailability.

  本发明涉及药学技术领域，涉及一种基于淋巴介导运输的甘油三酯原药，具体涉及一种淋巴介导运输中不同连接键链的甘油三酯原药及其制备方法和在给药中的应用。本发明提供了一种不同连接键的原药及其合成方法。原药的结构如下图所示。X、R1、R2、n和m在权利要求和说明中有所描述。根据本发明提供的原药，利用甘油三酯的结构模拟了甘油在胃肠道的消化吸收机理，促进了药物的淋巴转运，避免了首过效应，原药具有靶向性，能明显提高或改善药物的口服生物利用度。